2-Chloro-3',4'-Dihydroxyacetophenone 2-氯-3,4-二羟基苯乙酮

CAS 99-40-1 MFCD00002200

化学结构图

99-40-1
SMILES: O=C(CCl)c1ccc(O)c(O)c1

化学属性

Mol. FormulaC8H7ClO3
Mol. Weight186.59
Melting Point174-176°C
TSCANo
Boiling Point418.7±35.0 °C at 760 mmHg

别名和识别编码

Chemical Name2-Chloro-3',4'-Dihydroxyacetophenone
MDL NumberMFCD00002200
CAS Number99-40-1
Synonym 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone {LY} 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone {} {LY} 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone {} {} {LY} 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone {} {} {} {LY} 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone {} {} {} {} {LY} 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone {} {} {} {} {} {LY} 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone {} {} {} {} {} {} { {} {} {} {} {} {} {LY} 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone {} {} {} {} {} {} {} {LY} 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone {} {} {} {} {} {} {} {} {LY} 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone
PubChem Substance ID66834
EC Number202-754-8
Beilstein Registry Number2092660
Alfabeta NameCHLORODIHYDROXYPHENYLETHANONE 2134()----,
Chemical Name Translation2-氯-3,4-二羟基苯乙酮
Reaxys-RN2092660
LabNetwork Molecule IDLN00178233
InChIInChI=1S/C8H7ClO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,10-11H,4H2
Canonical SMILESOC1=CC=C(C(CCl)=O)C=C1O
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分类

  • {S
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards N - O, Pharmaceutical Standards, Pharmacopeia Standards
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards N - O, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Bioactive Small Molecules, Building Blocks, C-CH, C7 to C8, Carbonyl Compounds, Chemical Synthesis,
  • {SNA} Analytical Standards, EP Standards, EP Standards N - O, Pharmacopeia Metrological Institutes Standards, 分析/色谱
  • {SNA} Building Blocks,
  • {SNA} Building Blocks, C7 to C8,

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
Signal word
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Warnings IRRITANT
Hazard Codes Xi
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • 方法一:将儿茶酚和氯乙酸加入干燥的反应锅内，升温至60℃，搅拌，85-90℃保温0.5h。冷至65℃以下，加入三氯氧磷，60-70℃反应4h，70-80℃反应4h，待反应物稠厚搅拌困难时，加水，升温，90-100℃水解0.5h。冷却结晶，冷至10℃以下，甩滤，固体物用水洗至中性，得2-氯-3',4'-二羟基苯乙酮。
  • 下游产品:肾上腺酮
  • Sigma Aldrich:99-40-1(sigmaaldrich)
  • MOL 文件:99-40-1.mol
  • 用途一:止血药安络血、拟肾上腺素药物喘息灵等的中间体。
  • 上游原料:三氯氧磷 --> 氯乙酸 --> 邻苯二酚
  • Alfa Aesar:2-氯-3',4'-二羟基苯乙酮,97% 2-Chloro-3',4'-dihydroxyacetophenone, 97%(99-40-1)
  • 3,4-二羟基-2'-氯苯乙酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0156 4-(氯乙酰基)苯邻二酚 4-(Chloroacetyl)catechol 25G 493元 2010/05/25 B23496 2-氯-3',4'-二羟基苯乙酮, 97% 2-Chloro-3',4'-dihydroxyacetophenone, 97% 500g 4144元 2010/05/25 B23496 2-氯-3',4'-二羟基苯乙酮, 97% 2-Chloro-3',4'-dihydroxyacetophenone, 97% 25g 358元
  • TCI Shanghai:4-氯乙酰基-1,2-苯二酚 4-(Chloroacetyl)catechol,>;97.0%(T)(99-40-1)
  • 图谱信息:3,4-二羟基-2'-氯苯乙酮(99-40-1)质谱(MS) 3,4-二羟基-2'-氯苯乙酮(99-40-1)Raman光谱 3,4-二羟基-2'-氯苯乙酮(99-40-1)红外图谱(IR2) 3,4-二羟基-2'-氯苯乙酮(99-40-1)核磁图( 1 HNMR) 3,4-二羟基-2'-氯苯乙酮(99-40-1)红外图谱(IR1)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. C-CH - Bioactive Small Molecules
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Ketones - Carbonyl Compounds
  6. C7 to C8 - Ketones

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