Benzoic acid, 2-​hydroxy-​, sodium salt (1:1) 2-羟基苯甲酸钠

CAS 54-21-7 MFCD00002440

化学结构图

54-21-7
SMILES: [Na+].[O-]C(=O)C1C=CC=CC=1O

化学属性

Mol. FormulaC7H5NaO3
Mol. Weight160.10
Density1.015
Melting Point>300 °C
TSCAYes
SolubilitySoluble in water (1000 g/l) at 20 °C, ethanol, and glycerol.
Stability对光敏感

别名和识别编码

Chemical NameBenzoic acid, 2-​hydroxy-​, sodium salt (1:1)
Synonym Sodium Salicylate {LY} Sodium Salicylate {} {LY} Sodium Salicylate {} {} {LY} Sodium Salicylate {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {}
CAS Number54-21-7
EC Number200-198-0
Beilstein Registry Number3732792
MDL NumberMFCD00002440
PubChem Substance ID24899533
Merck Number14,8332
Chemical Name Translation2-羟基苯甲酸钠
Wiswesser Line NotationQVR BQ &-NA-
LabNetwork Molecule IDLN03240012
Canonical SMILESO=C(O[Na])C1=CC=CC=C1O
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分类

  • {SNA} Carbohydrates, Core Bioreagents, Pharmacopoeia, Pharmacopoeia A-Z,
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards S - T, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Analytical Reagents for General Use, Essential Chemicals, Puriss p.a.,

产品应用

  • 有机合成原料；防腐剂；测胃液中游离酸的试剂；点滴分析二氧化铀。解热镇痛药和抗风湿药。

相关文献及参考

  • Short: II/3
  • Short: IV/1a
  • Short: IV/1b
  • Merck:14,8332 Beilstein: 10,IV,125
  • Merck:14,8332

安全信息

Signal word Warning
GHS Symbol
WGK Germany1
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36 Irritating to eyes 刺激眼睛
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P352
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSVO5075000
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture Light Sensitive {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {}
Hazard Codes Xn 
TYPE OF TEST            : LDL

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 540 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 5,572,1955

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Behavioral - toxic psychosis
   Lungs, Thorax, or Respiration - respiratory stimulation
   Skin and Appendages - sweating
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   126,806,1944

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APSVAM Acta Paediatrica Scandinavica.  (Almqvist & Wiksell International,
   POB 4627, S-11691 Stockholm, Sweden)  V.54-80    1965-91    For publisher
   information, see APAEEL  Volume(issue)/page/year: 59,517,1970

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1392,1935

{hazard_co

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 370,1,1996

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 240 mg/L
REFERENCE :
   BIORAK Biochemistry (English Translation).  Translation of BIOHAO.  (Plenum
   Pub. Corp., 233 Spring St., New York, NY 10013)  V.21-    1956-
   Volume(issue)/page/year: 34,934,1969

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 30 mg/L
REFERENCE :
   BIORAK Biochemistry (English Translation).  Translation of BIOHAO.  (Plenum
   Pub. Corp., 233 Spring St., New York, NY 10013)  V.21-    1956-
   Volume(issue)/page/year: 34,934,1969

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 600 mg/kg
REFERENCE :
   BIOHAO Biokhimiya (Moscow).  For English translation, see BIORAK.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 34,1151,1969

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 370,1,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : female 6-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 33,43A,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 41(12),32,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 500 mg/kg
SEX/DURATION            : female 17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 220,385,1968

其他信息

  • 下游产品:水杨酸 --> 柳酸苄酯 --> 3,6-二氯-2-羟基苯甲酸 --> 媒介黄 1
  • Acros Organics:水杨酸钠 Salicylic acid, sodium salt, 99+%(54-21-7)
  • 易溶于水（1：0.8，25℃）和甘油（1：5），能溶于95%乙醇（1：11），几乎不溶于醚、氯仿和苯。水溶液呈微酸性（pH5-6）。久露光线中变粉红色。无臭或微带特殊的臭气，味甜呀不适。
  • 图谱信息:水杨酸钠(54-21-7)红外图谱(IR1) 水杨酸钠(54-21-7)红外图谱(IR2) 水杨酸钠(54-21-7)Raman光谱
  • F:8
  • 用途三:有机合成原料、防腐剂、测胃液中游离酸的试剂。解热镇痛药和抗风湿药。
  • Alfa Aesar:水杨酸钠,99% Sodium salicylate, 99%(54-21-7)
  • MOL 文件:54-21-7.mol
  • 用途一:解热镇痛、抗风湿药，用于活动性风湿病、类风湿关节炎等疾病的治疗
  • MSDS 信息:水杨酸钠(54-21-7).msds
  • 上游原料:连二亚硫酸钠 --> 水杨酸 --> 乙二胺四乙酸
  • 水杨酸钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30169317 水杨酸钠 250g 27元 2011/08/23 30169327 水杨酸钠 250g 26元 2011/08/23 HW6610901 水杨酸钠 250g 475元
  • 海关编码:29182100
  • 用途二:用于微量分析测定二氧化铀及有机合成，还用作防腐剂等
  • 方法一:将水杨酸和碳酸氢钠交叉加入蒸馏水中，温度保持60℃，并保持呈酸性状态，同时加入适量乙二胺四乙酸（EDTA）及保险粉。升温至85℃，反应半小时。将合格的反应液经过滤送入沸腾床，85℃干燥得水杨酸。
  • Sigma Aldrich:54-21-7(sigmaaldrich)
  • 用途四:有机合成原料；防腐剂；测胃液中游离酸的试剂；点滴分析二氧化铀。解热镇痛药和抗风湿药。
  • 外观性质:白色鳞片或粉末，无气味，久露光线中变粉红色。
  • 敏感性:Light Sensitive

系列性分类

  1. Application Areas 应用领域分类
  2. Drug Discovery 新药研发
  3. Pharmacopoeia 药典
  4. Pharmacopoeia A-Z - Pharmacopoeia
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Aromatic Compounds - Phytochemicals by Chemical Classification
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Analytical Reagents for General Use - Analytical Reagents
  4. Puriss p.a. - Analytical Reagents for General Use
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acid Salts - Carbonyl Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Analytical Reagents for General Use - Analytical Reagents
  4. Puriss p.a. - Analytical Reagents for General Use
  5. Q-S, Puriss p.a. - Puriss p.a.
  1. Analytical & Chromatography 分析化学与色谱
  2. Adsorbents, Filter Aids and Drying Agents
  3. Other Drying Agents
  1. Functional Group 官能团索引
  2. carboxylic acid salt
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals Found in Plants
  4. Antioxidant
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nutrition Research
  4. Biochemicals Found in Plants
  5. Antioxidant