4-Chloromercuribenzoic acid 对氯汞苯甲酸

CAS 59-85-8 MFCD00002526

化学结构图

59-85-8
SMILES: O=C(O)c1ccc([Hg]Cl)cc1

化学属性

Mol. FormulaC7H4ClHgO2.H
Mol. Weight357.16
Melting Pointca 287° dec.
TSCAYes
Solubility不溶于水，溶于乙醇。

别名和识别编码

Chemical Name4-Chloromercuribenzoic Acid
CAS Number59-85-8
Synonym 4-carboxyphenylmercuricchloride PCMB usafd-3 4-CHLOROMERCURIBENZOIC ACID P-CMBA p-chloro-mercuricbenzoicacid Mercurate(1-), (4-carboxylatophenyl)chloro-, hydrogen P-(CHLOROMERCURIO)BENZOIC ACID p-Chloro-mercuric benzoic acid 对氯化汞苯甲酸 4-氯苯甲酸汞 (p-carboxyphenyl)chloro-mercur 4-Carboxyphenylmercuric chloride 对氯高汞苯甲酸 Benzoic acid, p-(chloromercuri)- 4-(HYDROXYMERCURIO)BENZOIC ACID p-carboxyphenylmercuricchloride p-(chloromercuri)-benzoicaci 4-氯汞苯甲酸 4-(CHLOROMERCURIO)BENZOIC ACID 4-Carboxyphenylmercuric Chloride P-CHLOROMERCURIBENZOIC ACID (p-Carboxyphenyl)chloromercury 对氯汞苯甲酸 P-CHLOROMERCURIBENZOIC ACID, FREE ACID (4-carboxyphenyl)chloromercury 4-(Chloromercuric)benzoic acid (4-carboxylatophenyl)chloro-mercurate(1-hydrogen NSC 32866 (4-Carboxyphenyl)chloromercury 4-(CHLOROMERCURI)BENZOIC ACID 95% (& P-CMB 4-(HYDROXYMERCURI)BENZOIC ACID USAF D-3 p-Chloromercuribenzoic acid p-Carboxyphenylmercuric chloride
Beilstein Registry Number3662892
PubChem Substance ID24278323
EC Number200-442-6
MDL NumberMFCD00002526
Chemical Name Translation对氯汞苯甲酸
Wiswesser Line NotationQVR D-HG-G
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分类

  • A to C, Alcohol oxidase, Aldehyde dehydrogenase, Amino acid oxidase, D-, Apoptosis Enzymes, Application Index, Asparaginase, Biochemicals and Reagents, Calpain, Calpain II, Calpain II Inhibitors, Carboxypeptidase P, Cell Signaling Enzymes, Chemical Synthesis, Clostripain, Creatine Phosphokinase, D to K, Dihydrofolate reductase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Folic Acid Metabolism, General Inhibitors, Glucosidase, beta-, Glycobiology,
  • {SNA} A to C,

产品应用

  • A useful sulfhydryl reagent that reacts with Histidine 225C, a residue of the NhaA-Na/H Antiporter of Escherichia Coli.

相关文献及参考

  • Olami, Y. et al.: J. Biol. Chem., 272, 3, 1761 (1997).
  • Kanauchi, M., et al., Purification and characteristics of feruloyl esterase from Aspergillus awamori G-2 strain. J. Food Sci. 73 , 458-63, (2008) 摘要
  • Shpakov A.O., and Derkach, K.V., The role of sulfhydryl groups in functioning of components of adenylate cyclase signal system in smooth muscles of the mollusk Anodonta cygnea (effect of N-ethylmaleimide and p-chloromercuribenzoic acid) Tsitologia 41 , 499-505, (1999)
  • Beil. 16 ,IV,1750
  • Aldrich MSDS 1 , 411:C / Corp MSDS 1 (1), 794:C / FT-IR 1 (2), 1149:C / FT-IR 2 (3), 4509:A / IR-Spectra (2), 1335:E / IR-Spectra (3), 1562:H / NMR-Reference 2 (2), 982:C / RegBook 1 (2), 3071:C / Sax 6 , 729 / Sigma FT-IR 1 (2), 381:A / Structure Index 1 , 487:D:3

安全信息

Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
RTECSOV8050000
WGK Germany3
GHS Symbol
Signal word Danger
Hazard statements
  • H330 Fatal if inhaled 吸入致命
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H310 Fatal in contact with skin 皮肤接触致命
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H300 Fatal if swallowed 吞食致命
Hazard Codes T+,N
Safety Statements
  • S13 Keep away from food, drink and animal foodstuffs 远离食品、饮料和动物饲料保存；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S57 Use appropriate containment to avoid environmental contamination 使用适当容器避免环境污染；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S27/28
UN Number UN 2025 6.1/PG 2 UN2026
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
  • R50/53
  • R33 Danger of cumulative effects 有累积作用的危险
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Packing GroupII
Hazard Class6.1(a)
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

其他信息

  • 职业标准:TWA 0.05 毫克 (汞)/ 立方米; STEL 0.15 毫克 (汞)/ 立方米
  • 毒性分级:剧毒
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 灭火剂:二氧化碳、砂土、水、泡沫
  • 图谱信息:对氯汞苯甲酸(59-85-8)红外图谱(IR2) 对氯汞苯甲酸(59-85-8)质谱(MS) 对氯汞苯甲酸(59-85-8)核磁图( 1 HNMR) 对氯汞苯甲酸(59-85-8)红外图谱(IR1)
  • 对氯汞苯甲酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80034180 对氯汞苯甲酸 5g 136元
  • 可燃性危险特性:高热分解有毒汞化物和氯化物气体
  • MOL 文件:59-85-8.mol
  • F:3-8-10
  • Sigma Aldrich:59-85-8(sigmaaldrich)
  • 急性毒性:腹腔-小鼠 LD50: 25 毫克/公斤
  • 外观性质:白色结晶粉末。
  • MSDS 信息:对氯化汞苯甲酸(59-85-8).msds
  • 类别:有毒物品

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. D to K - Enzyme Inhibitors by Enzyme
  7. Glucosidase, beta- - D to K
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Cell Signaling Enzymes - Application Index
  6. Dihydrofolate reductase - Cell Signaling Enzymes
  7. Inhibitors - Dihydrofolate reductase
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Alcohol oxidase - A to C
  1. Life Science 生命科学
  2. Proteomics 蛋白质组学
  3. Protein Structural Analysis - Proteomics
  4. Protein Sequencing - Protein Structural Analysis
  5. Reagents for Protein Sequencing - Protein Sequencing
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Metal Compounds 金属化合物

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