Oxobutanedioic acid 草酰乙酸

CAS 328-42-7 MFCD00002592

化学结构图

328-42-7
SMILES: O=C(O)CC(=O)C(=O)O

化学属性

Mol. FormulaC4H4O5
Mol. Weight132.07
Melting Point161°C
Flash Point174.8°C
TSCAYes
Solubility可溶
Density1.631
Appearance powder 草酰乙酸(328-42-7)为白色结晶或粉末。
Boiling Point341.9°C at 760 mmHg

别名和识别编码

Chemical NameOxobutanedioic acid
CAS Number328-42-7
Synonym Oxaloacetic acid {LY} Oxaloacetic acid {} {LY} Oxaloacetic acid {} {} {LY} Oxaloacetic acid {} {} {} {LY} Oxaloacetic acid {} {} {} {} {LY} Oxaloacetic acid {} {} {} {} {} {LY} Oxaloacetic acid {} {} {} {} {} {} {LY} Oxaloacetic acid {} {} {} {} {} {} {} {LY} Oxaloacetic acid {} {} {} {} {} {} {} {} {LY} Oxaloacetic acid {} {} {} {} {} {} {} {} {} {LY} Oxaloacetic acid {} {} {} {} {} {} {} {} {} {} {LY} Oxaloacetic acid {} {} {} {} {} {} {} {} {} {} {} {LY} Oxaloacetic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Oxaloacetic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Oxaloacetic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Oxaloacetic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Oxaloacetic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Beilstein Registry Number1705475
PubChem Substance ID970
EC Number206-329-8
MDL NumberMFCD00002592
Reaxys-RN1705475
Merck Number6909
Chemical Name Translation草酰乙酸
LabNetwork Molecule IDLN00194956
InChIInChI=1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)
Canonical SMILESO=C(O)C(CC(O)=O)=O
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分类

  • {SNA} Aspartate transaminase, Biochemicals and Reagents, Cell Biology, Citrate synthase, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Malate Dehydrogenase, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, Oxaloacetate decarboxylase, Substrates by Enzyme,
  • {SNA} Conditioned Media, Media Supplements and Reagents, Hybridoma Media Supplements, Hybridoma Platform, Hybridoma Reagents, 无血清培养基, 细胞培养, 试剂和添加剂
  • {SNA} Companion Products and Reagents, Insect Platform, Miscellaneous Reagents and Supplements, 无血清培养基, 细胞培养,

产品应用

  • 柠檬酸合成酶（citrate synthase）和苹果酸脱氢酶（malate dehydrogenase）
  • 的底物。也可作为琥珀酸脱氢酶的抑制剂。

相关文献及参考

  • [2]. Brian D Fink, et al. Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration. J Biol Chem. 2018 Dec 21;293(51):19932-19941.
  • Merck: 14,6909
  • Merck: 14,6909 Beilstein:3,777
  • Substrate for citrate synthase.
  • Zeylemaker, W.P. et al.: Biochim. Biophys. Acta Enzymol., 132, 210 (1967); Dalla-Betta, P. et al.: Int. J. Mol. Sci., 10, 2809 (2009);
  • [1]. F. L. Breusch. The fate of oxaloacetic acid in different organs. Biochem J. 1939 Nov; 33(11): 1757–1770.
  • [1]. F. L. Breusch. The fate of oxaloacetic acid in different organs. Biochem J. 1939 Nov; 33(11): 1757–1770.
  • [2]. Brian D Fink, et al. Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration. J Biol Chem. 2018 Dec 21;293(51):19932-19941.

安全信息

Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
WGK Germany3
GHS Symbol
Signal word Danger
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Hazard Codes 8 C
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
UN Number 3261 UN 3261 8/PG 2
Storage condition -20°C {LY} -20°C 0-10 0-10°C {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Safety Statements
  • S20 When using do not eat or drink 使用时，不得进食，饮水；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R34 Causes burns 会导致灼伤
Packing GroupII
Hazard Class8

其他信息

  • Acros Organics:草酰乙酸/丁酮二酸 Oxalacetic acid, 98%(328-42-7)
  • 图谱信息:草酰乙酸(328-42-7)红外图谱(IR2) 草酰乙酸(328-42-7)红外图谱(IR1) 草酰乙酸(328-42-7)质谱(MS)
  • 草酰乙酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 O0072 草酰乙酸 Oxalacetic Acid 10G 947元 2010/06/21 416600250 草酰乙酸 Oxalacetic acid 98% 25 GR 2191元 2010/06/21 416600050 草酰乙酸 Oxalacetic acid 98% 5 GR 589元
  • 用途一:柠檬酸合成酶（citrate synthase）和苹果酸脱氢酶（malate dehydrogenase）的底物。也可作为琥珀酸脱氢酶的抑制剂。
  • Sigma Aldrich:328-42-7(sigmaaldrich)
  • Alfa Aesar:草酰乙酸,98+% Oxalacetic acid, 98+%(328-42-7)
  • 三羧酸循环的一个环节。是在苹果酸脱氢酶的催化下由苹果酸生成的，它与乙酰辅酶A缩合生成柠檬酸，开始新的循环。在丙酮酸羧化酶的作用下，由丙酮酸与CO2生成，另外，也在转氨酶（EC 2．6．1．1）的作用下由天冬氨酸生成。溶于水。
  • TCI Shanghai:草酰乙酸 Oxalacetic Acid,>;98.0%(T)(328-42-7)
  • MOL 文件:328-42-7.mol
  • 下游产品:柠檬酸 --> 草酰乙酸二乙酯

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Life Science 生命科学
  2. Cell Culture 细胞培养
  3. Serum-free Media - Cell Culture
  4. Hybridoma Platform - Serum-free Media
  5. Hybridoma Media Supplements - Hybridoma Platform
  1. Life Science 生命科学
  2. Cell Culture 细胞培养
  3. Serum-free Media - Cell Culture
  4. Insect Platform - Serum-free Media
  5. Companion Products and Reagents - Insect Platform
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  6. C1 to C5 - Carboxylic Acids
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Pathways - Metabolomics
  4. Metabolites and Cofactors on the Metabolic Pathways Chart - Metabolic Pathways
  5. TCA - Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Substrates by Enzyme - Enzyme Substrates
  6. Aspartate transaminase - Substrates by Enzyme
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Substrates by Enzyme - Enzyme Substrates
  6. Oxaloacetate decarboxylase - Substrates by Enzyme
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Arylamine N-methyltransferase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Chymotrypsin, alpha
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Lyticase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Nitric Oxide Synthase/NO Donor
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  6. Porphyrin
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Pathways
  6. Metabolites and Cofactors on the Metabolic Pathways Chart
  7. Porphyrin
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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