(S)-2-Amino-4-(ethylthio)butanoic acid L-乙硫氨酸

CAS 13073-35-3 MFCD00002626

化学结构图

13073-35-3
SMILES: CCSCCC(N)C(O)=O

化学属性

Mol. FormulaC6H13NO2S
Mol. Weight163.24
Melting Point280 °C (dec.) (lit.)

别名和识别编码

Chemical Name(S)-2-Amino-4-(ethylthio)butanoic acid
CAS Number13073-35-3
Synonym L-乙硫氨基酪酸 ETH L-2-氨基-4-(乙硫基)丁酸 L-Ethionine L-2-Amino-4-(ethylthio)butyric acid S-Ethyl-L-homocysteine L-Homocysteine, S-ethyl- Ethionine
MDL NumberMFCD00002626
PubChem Substance ID87569352
EC Number235-966-4
Reaxys-RN1722528
Beilstein Registry Number4(3)1643
Merck Number3738
Chemical Name TranslationL-乙硫氨酸
Wiswesser Line NotationQVYZ2S2
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分类

  • Amino Acids & Derivatives
  • Sulfur & Selenium Compounds
  • {SNA} Cancer Research, Carcinogens, Cell Biology
  • {SNA} Cancer Research, Carcinogens
  • {SNA} 癌症研究, 细胞生物学, 致癌物

产品应用

  • Ethionine-induced inhibition of protein synthesis and lowering of ATP level in the liver.

相关文献及参考

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安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P305+P351+P338
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSES6825300
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44100 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 7,1143,1986

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 5 mg/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 4,291,1983

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   CGCGBR Cytogenetics and Cell Genetics.  (S. Karger Pub., Inc., 79 Fifth
   Ave., New York, NY 10003) V.12-    1973-  Volume(issue)/page/year:
   44,209,1987

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 4 mmol/L
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   520,139,1978

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 8,1059,1987

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   520,139,1978

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2 gm/L
REFERENCE :
   CYTOAN Cytologia.  (Japan Pub. Trading Co. (USA), 1255 Howard St., San
   Francisco, CA 94103) V.1-    1929-  Volume(issue)/page/year: 50,387,1985

系列性分类


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