CAS 1138-80-3 MFCD00002691-N-Carbobenzoxyglycine N-苄氧羰基-甘氨酸 -LabNovo

N-Carbobenzoxyglycine N-苄氧羰基-甘氨酸

CAS 1138-80-3 MFCD00002691

化学结构图

SMILES: O=C(O)CNC(=O)OCc1ccccc1

化学属性

Mol. Formula	C10H11NO4
Mol. Weight	209.20
Density	1.289
Melting Point	118-122°C
TSCA	Yes
Appearance	白色结晶或结晶性粉末；溶于甲醇和氯仿，不溶于冷水；mp为119-120℃。
Solubility	methanol: 0.1 g/mL, clear
Boiling Point	424°C at 760 mmHg
pH	:A

别名和识别编码

Chemical Name	N-Carbobenzoxyglycine
MDL Number	MFCD00002691
CAS Number	1138-80-3
EC Number	214-516-0
Beilstein Registry Number	526877
Synonym	Z-Glycine {LY} Z-Glycine {} {LY} Z-Glycine {} {} {LY} Z-Glycine {} {} {} {LY} Z-Glycine {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID	14349
Reaxys-RN	526877
Chemical Name Translation	N-苄氧羰基-甘氨酸
Wiswesser Line Notation	QVN1R&1VQ
InChIKey	CJUMAFVKTCBCJK-UHFFFAOYSA-N
InChI	InChI=1S/C10H11NO4/c12-9(13)6-11-10(14)15-7-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,14)(H,12,13)
LabNetwork Molecule ID	LN00223153
Canonical SMILES	O=C(O)CNC(OCC1=CC=CC=C1)=O

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品牌质保精细包装现货库存一流品牌服务

产品应用

用于生化试剂，地拉普利,氟地西泮,甲磺酸氯普唑仑和其它多肽合成。

安全信息

Signal word Warning

GHS Symbol

WGK Germany3

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Risk Statements

R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。

RTECSMB9129000

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Storage condition 2-8°C {LY} 2-8°C Store at RT. Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 68,696,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 280 mg/kg
SEX/DURATION            : female 28 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 70,60,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 280 mg/kg
SEX/DURATION            : female 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 70,60,1981

其他信息

毒性分级:中毒
储运特性:库房低温通风干燥
图谱信息:N-CBZ-L-丙氨酸(1138-80-3)核磁图( 1 HNMR) N-CBZ-L-丙氨酸(1138-80-3)质谱(MS) N-CBZ-L-丙氨酸(1138-80-3)红外图谱(IR1) N-CBZ-L-丙氨酸(1138-80-3)红外图谱(IR2)
用途一:用作多肽试剂
用途三:有机中间体。
方法二:在冷却下，将氯甲酸苄酯和氢氧化钠溶液滴加到甘氨酸和氢氧化钠溶液的混合物中，同时激烈搅拌。反应毕，静置分出油层。水层用乙醚提取后冷却酸化至刚果红酸性，滤了沉淀，水洗、干燥，得产品苄氧羰基甘氨酸。产率86-91%。
上游原料:甘氨酸 --> 氯甲酸苄酯 --> 直接红 28
可燃性危险特性:热分解排出有毒氮氧化物烟雾
Alfa Aesar:N-苄氧羰基甘氨酸,98+% N-Benzyloxycarbonylglycine, 98+%(1138-80-3)
急性毒性:叶鞘-小鼠 LD50: 380 毫克/公斤
MOL 文件:1138-80-3.mol
用途四:用于生化试剂，地拉普利,氟地西泮,甲磺酸氯普唑仑和其它多肽合成。
N-CBZ-L-丙氨酸价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 C0575 N-苄氧羰基甘氨酸 N-Carbobenzoxyglycine 25G 279元 2014/06/02 C0575 N-苄氧羰基甘氨酸 N-Carbobenzoxyglycine 500G 2480元 2010/06/21 108355000 N-CBZ-L-丙氨酸 N-Carbobenzyloxyglycine 98.5% 500 GR 3923元
类别:有毒物质
方法一:以苄氧羰基叠氮和甘氨酸为原料，碱性条件下反应得粗品，再经乙醚提取、重结晶得纯品。
用途二:用于多肽合成，用作氨基酸保护单体。
Acros Organics:N-苄氧羰酰甘氨酸 N-Carbobenzyloxyglycine, 98.50%(1138-80-3)
TCI Shanghai:N-苄氧羰基氨基乙酸 N-Carbobenzoxyglycine,>;98.0%(LC)(T)(1138-80-3)
MSDS 信息:Benzyloxycarbonyl glycine(1138-80-3).msds
参考质量标准:含量不少于98%；mp118-120℃；乙醇溶解试验薄层层析试验合格。
灭火剂:水, 干粉, 二氧化碳, 泡沫
海关编码:29242995