Sodium butyrate 丁酸钠

CAS 156-54-7 MFCD00002816

化学结构图

156-54-7
SMILES: CCCC(=O)[O-].[Na+]

化学属性

Mol. FormulaC4H7NaO2
Mol. Weight110
Melting Point250-253
TSCAYes
Density0.987
Solubility可溶
Stability易吸潮
Appearance 丁酸钠(156-54-7)为白色粉末，具有特殊的酸牛奶气味。

别名和识别编码

Chemical NameSodium butyrate
Synonym Acid, Butanoic Acid, Butyric Butanoic Acid Butanoic acid, sodium salt Butanoicacid,sodiumsalt Butanoicacidsodiumsalt Butyrate, Magnesium Butyrate, Sodium Butyric Acid Butyric Acid Magnesium Salt Butyric Acid, Sodium Salt Butyric acid sodium salt Dibutyrate, Magnesium Magnesium Butyrate Magnesium Dibutyrate SODIUM BUTANOATE SODIUM N-BUTYRATE Sodium Butyrate Sodium butyrate Sodium butyrate, 98+% Sodium propanecarboxylate sodium butyrate 正丁酸钠
CAS Number156-54-7
PubChem Substance ID5222465
EC Number205-857-6
Beilstein Registry Number3629439
MDL NumberMFCD00002816
Reaxys-RN3629439
Chemical Name Translation丁酸钠
Wiswesser Line NotationOV3 &-NA-
LabNetwork Molecule IDLN00195599
InChIInChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
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分类

  • {SNA} Bioactive Small Molecules, Building Blocks, Carbonyl Compounds, Carboxylic Acid Salts, Chemical Synthesis, Organic Building Blocks, S, 细胞生物学
  • {SNA} Building Blocks, Carbonyl Compounds, Carboxylic Acid Salts, Chemical Synthesis, Organic Building Blocks
  • {SNA} Bioactive Small Molecules
  • {SNA} Bioactive Small Molecules for Epigenetic Research, Core Bioreagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, General Reagents, Histone Deacetylase Inhibitors, Histone deacetylase, Intracellular Calcium Regulators, Intracellular Calcium Signaling, Life Science Reagents for RNAi, Research Essentia

产品应用

  • 减少细胞内Ca2+ 的释放。抑制组蛋白脱乙酰酶(HDAC)，诱导细胞凋亡。

相关文献及参考

  • Short: IV/1a
  • Short: III/31a
  • Beilstein:2(4)779
  • Short: IV/1b

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn Xi
RTECSET6400000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37 Wear suitable gloves 戴适当手套；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
Storage condition 易吸潮，密封保存。 -20°C Hygroscopic
UN Number 2820 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   46,713,1986

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Mammal - domestic Mammary gland
DOSE/DURATION           : 10 umol/L
REFERENCE :
   CBRPDS Cell Biology International Reports.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1977-  Volume(issue)/page/year:
   11,557,1987

TYPE OF TEST            : DNA inhibit

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,6560,1988

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,6560,1988

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   42,1052,1982

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   INOPAO Investigative Ophthalmology.  (St. Louis, MO

其他信息

  • 溶于水，不溶于醚。
  • 用途一:减少细胞内Ca2+ 的释放。抑制组蛋白脱乙酰酶(HDAC)，诱导细胞凋亡。
  • 储运特性:库房低温, 通风, 干燥
  • 丁酸钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010245 丁酸钠 250g 350元 2011/04/16 S0519 丁酸钠 Sodium Butyrate 25G 202元 2011/04/16 S0519 丁酸钠 Sodium Butyrate 500G 1260元
  • F:3-10
  • 灭火剂:水, 二氧化碳, 干粉, 泡沫
  • MSDS 信息:Butyric acid sodium salt(156-54-7).msds
  • TCI Shanghai:丁酸钠 Sodium Butyrate,>;98.0%(T)(156-54-7)
  • 可燃性危险特性:可燃, 火场排出氧化钠辛辣刺激烟雾
  • Acros Organics:正丁酸钠 Butyric acid sodium salt, 99%(156-54-7)
  • 敏感性:Hygroscopic
  • Sigma Aldrich:156-54-7(sigmaaldrich)
  • Alfa Aesar:丁酸钠,98+% Sodium butyrate, 98+%(156-54-7)
  • 下游产品:丁酸酐 --> 碘番酸 --> 2-(4-异丁基苯基)丙醛 --> 乙酰乙酸正丁酯 --> 丁酸苯甲酯 --> 2-乙基丁酸烯丙酯
  • 类别:有毒物品
  • 海关编码:29156019
  • MOL 文件:156-54-7.mol

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. S - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Intracellular Calcium Signaling - Cell Signaling and Neuroscience
  5. Intracellular Calcium Regulators - Intracellular Calcium Signaling
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acid Salts - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acid Salts - Carbonyl Compounds
  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. Epigenetics - Molecular Biology
  4. Bioactive Small Molecules for Epigenetic Research - Epigenetics
  5. Histone Deacetylase Inhibitors - Bioactive Small Molecules for Epigenetic Research
  6. Short-Chain Fatty Acid Inhibitors - Histone Deacetylase Inhibitors
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acid Anhydrides
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Dry Powder Media
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Intracellular Calcium Signaling
  5. Calcium Signaling Research Tools
  6. Calcium Probes
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Histinol Dehydrogenase