Isoxazole 异噁唑

CAS 288-14-2 MFCD00003149

化学结构图

288-14-2
SMILES: C1CNOC1

化学属性

Mol. FormulaC3H3NO
Mol. Weight69.063
Boiling Point95.5°C at 760 mmHg
Density1.078
Refractive index1.4240 to 1.4280
Flash Point12°C
TSCAYes
Vapor Density2.4 (vs air)
Appearance 类似吡啶的液体。
Solubility室温下溶于6倍的水中。
pH:A
Melting Point-67.1 °C

别名和识别编码

Chemical NameIsoxazole
CAS Number288-14-2
Alfabeta NameISOXAZOLE
MDL NumberMFCD00003149
Synonym Isoxazole {LY} Isoxazole {} {LY} Isoxazole {} {} {LY} Isoxazole {} {} {} {LY} Isoxazole {} {} {} {} {LY} Isoxazole {} {} {} {} {} {LY} Isoxazole {} {} {} {} {} {} {LY} Isoxazole {} {} {} {} {} {} {} {LY} Isoxazole {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} Isoxazole {} {} {} {} {} {} {} {} {} {LY} Isoxazole {} {} {} {} {} {} {} {} {} {} {LY} Isoxazole {} {} {} {} {} {} {} {} {} {} {} {LY} Isoxazole {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Isoxazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Isoxazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Isoxazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Isoxazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Isoxazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Isoxazole {} {} {} {} {} {} {} {} {} {} {} {}
EC Number206-018-7
Beilstein Registry Number27,14
PubChem Substance ID9254
Reaxys-RN103773
Chemical Name Translation异噁唑
LabNetwork Molecule IDLN00008095
InChIInChI=1S/C3H3NO/c1-2-4-5-3-1/h1-3H
Canonical SMILESC1=CON=C1
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分类

  • {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Isoxazoles
  • {uni_hamburg} no charge; oxygen heterocycle; nitrogen heterocycle; aromatic; 5ring; 1fragment

相关文献及参考

  • For a review of synthetic reactions using isoxazole compounds, see: Heterocycles, 12, 1343 (1979). For a review of isoxazole chemistry, see: Adv. Het. Chem., 25, 147 (1979).
  • Short: II/24C
  • Short: II/24B
  • Short: II/14a

安全信息

Warnings IRRITANT, FLAMMABLE
UN Number UN 1993 3/PG 2 1993
Risk Statements
Safety Statements
GHS Symbol
WGK Germany3
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P370+P378
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241+P242+P243
Signal word
Packing GroupII
Hazard Codes F
Hazard Class3
Storage condition -20°C {LY} -20°C Store at RT. {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C

其他信息

  • Acros Organics:异恶唑 Isoxazole, 99%(288-14-2)
  • MOL 文件:288-14-2.mol
  • 蒸气密度:2.4 (vs air)
  • 上游原料:盐酸羟胺 --> 1,1,3,3-四乙氧基丙烷
  • TCI Shanghai:异恶唑 Isoxazole,>;95.0%(GC)(288-14-2)
  • 用途一:用于有机合成
  • Sigma Aldrich:288-14-2(sigmaaldrich)
  • 异恶唑价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 I0372 异恶唑 Isoxazole 5G 636元 2010/06/21 412930500 异恶唑 Isoxazole 99% 50 GR 1907元 2010/06/21 412930100 异恶唑 Isoxazole 99% 10 GR 553元
  • MSDS 信息:Isoxazole(288-14-2).msds
  • Hazard Note:Highly Flammable
  • F:10
  • 异恶唑衍生物:磺胺甲基异恶唑(sulfamethoxazole，SMZ)又称“新诺明”、“新明磺”，属异恶唑衍生物，外观为白色结晶性粉末，熔点168～172°，无臭，味微苦。几乎不溶于水，易溶于稀盐酸和碱溶液。 药理作用与磺胺二甲异恶唑(SIZ)相似，不同点为在胃肠道吸收和尿中的排泄较后者为慢，故有效血浓度维持时间较长，半寿期为11小时，每日服药2次。属中效磺胺药。缺点为在体内乙酰化程度较高，在尿中的溶解度低，故产生血尿和结晶尿的机会较SIZ为多，因此在大剂量和长期应用时宜同服碳酸氢钠，适用于治疗急性泌尿道感染、呼吸道感染和皮肤化脓性感染等。本品与抗菌增效剂TMP合用，其抗菌作用有明显增高，临床应用范围亦扩大，可用于急性支气管炎、肺部感染、布氏杆菌病、菌痢等，疗效与氨苄青霉素、氯霉素、四环素等相近。 不良反应有白细胞减少、皮疹、胃肠道刺激等。大剂量长期服用时可能引起结晶尿、血尿。
  • 下游产品:2-氨基-5-氯二苯甲酮 --> 异恶草酮 --> 2-氨基-5-氯二苯酮肟 --> 氯唑磷 --> 利培酮 --> 唑尼沙胺 --> 2-甲氨基-5-氯二苯甲酮 --> 磺胺乙酰异噁 --> 苯唑青霉素钠
  • 海关编码:29349990
  • Alfa Aesar:异恶唑,99% Isoxazole, 99%(288-14-2)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoquinolines 异喹啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoxazoles 异恶唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoxazoles 异恶唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Oxazoles 恶唑

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