Androsterone 雄酮

CAS 53-41-8 MFCD00003618

化学结构图

53-41-8
SMILES: C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CCC2=O

化学属性

Mol. FormulaC19H30O2
Mol. Weight290.49
Melting Point181-184°C
Density1.085

别名和识别编码

Chemical NameAndrosterone
CAS Number53-41-8
Synonym (3?,5?)-3-Hydroxyandrostan-17-one (3R,5S,8R,10S,13S)-3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one (3R,5S,8R,10S,13S)-3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one 3 alpha Hydroxy 5 alpha Androstan 17 One 3α-羟基-5α-雄甾烷-17-酮 5α-Androstan-3α-ol-17-one 3-Epihydroxyetioallocholan-17-one 3-alpha-Hydroxy-17-androstanone 3-alpha-Hydroxy-5-alpha-Androstan-17-One 3-alpha-Hydroxy-5-alpha-androstan-17-one 3-alpha-Hydroxyetioallocholan-17-one 3?-Hydroxy-17-androstanone 3?-Hydroxy-5?-androstan-17-one 3?-Hydroxyetioallocholan-17-one 3A-Hydroxy-5A-androstan-17-on 3alpha-Hydroxy-5alpha-androstan-17-one; cis-Androsterone; Androstan-3a-ol-17-one; 3a-Hydroxy-5a-androstan-17-one 3α-Hydroxy-17-androstanone 3α-Hydroxyetioallocholan-17-one
MDL NumberMFCD00003618
PubChem Substance ID5879
Beilstein Registry Number2217626
EC Number200-173-4
Chemical Name Translation雄酮
InChIInChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1
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分类

  • 3.x.x.x Hydrolases, Biochemicals and Reagents, Chemical Synthesis, Enzyme Class Index, Enzyme Kits, Enzyme-Mediated Synthesis, Enzymes, Inhibitors, and Substrates, Others, Specialty Synthesis
  • {uni_hamburg} no charge; carbocycle; alicycle; large ring; fused rings; 5ring; 6ring; 9ring; 10ring; 13ring; 14ring; 17ring; ketone; alcohol; chiral; 1fragment
  • {SA} AN-AZ, Androgen, Asymmetric Synthesis, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis, Chiral Building Blocks, Complex Molecules, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones
  • {SNA} 3.x.x.x Hydrolases, Biochemicals and Reagents,

产品应用

  • 雄性激素和蛋白同化激素。

相关文献及参考

  • [2]. Kaminski RM, et al. Anticonvulsant activity of androsterone and etiocholanolone. Epilepsia. 2005 Jun;46(6):819-27.
  • Merck:13,645
  • Merck:13,645 Beilstein: 8,IV,642
  • Park, J., et al.: J. Anal. Toxicol., 14, 66 (1990),
  • Short: III/35E
  • Short: III/5b
  • [1]. Wang S, et al. The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone. Endocrinology. 2006 Sep;147(9):4025-33.
  • [1]. Wang S, et al. The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone. Endocrinology. 2006 Sep;147(9):4025-33.
  • [2]. Kaminski RM, et al. Anticonvulsant activity of androsterone and etiocholanolone. Epilepsia. 2005 Jun;46(6):819-27.

安全信息

Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
  • P302+P352
  • P304+P340
  • P304+P341
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P342+P311
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
GHS Symbol
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Signal word Danger
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
RTECSBV8053000 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 8400 ug/kg
SEX/DURATION            : male 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   21,313,1937

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 mg/kg
SEX/DURATION            : female 13-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   99,1490,1976

其他信息

  • 溶于醇, 不溶于水。

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Sterol Lipids - Lipids
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Market Segments - Analytical Standards
  4. Standards for Pharma Clinical Forensic & Veterinary Analysis - Market Segments
  5. Neats and Solutions - Standards for Pharma Clinical Forensic & Veterinary Analysis
  6. Hormones - Neats and Solutions
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Androgen - Steroid Hormones
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Class Index - Enzymes, Inhibitors, and Substrates
  5. 3.x.x.x Hydrolases - Enzyme Class Index
  6. Others - 3.x.x.x Hydrolases
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Steroids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Cytokines, Growth Factors and Hormones
  5. Hormones
  6. Steroid Hormones
  7. Aldosterone
  1. Medical Research Areas
  2. Metabolism
  3. FXR  (法尼酯X受体)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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