Desoxycortone 11-去氧皮质酮

CAS 64-85-7 MFCD00003661

化学结构图

64-85-7
SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO

化学属性

Mol. FormulaC21H30O3
Mol. Weight330.51
Melting Point138-144 ºC
Solubility略溶于水
Appearance 结晶(乙醇)。熔点141-142℃。[α]22/D+178°(乙醇)。易溶于乙醇、丙酮。

别名和识别编码

Chemical Name11-Deoxy Corticosterone
CAS Number64-85-7
Synonym ######## ‘Reichstein Q’ ‘Reichstein Q’ 11-Deoxycorticosterone 11-Desoxycorticosterone 21-Hydroxy-4-pregnene-3,20-dione 4-Pregnen-21-ol-3,20-dione Cortexone DOC Desoxycortone Kendall’s desoxy compound B (8S,10R,13S,17S)-17-(2-Hydroxy-acetyl)-10,13-dimethyl-1,2,6,7,8,9,10, (8S,10R,13S,17S)-17-(2-Hydroxy-acetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 11 Decorticosterone 11-DESOXYCORTICOSTERONE 11-Decorticosterone 11-Dehydroxycorticosterone 11-Deoxycorticosterone 11-Deoxycorticosterone; 21-Hydroxypregn-4-ene-3,20-dione; 21-Hydroxyprogesterone; 4-Pregnen-21-ol-3,20-dione; Cortexone 11-Desoxycortico 11-Desoxycorticosterone 11-脱氧肾上腺皮质甾酮 21 Hydroxy 4 pregnene 3,20 dione 21 Hydroxyprogest
MDL NumberMFCD00003661
PubChem Substance ID6166
Beilstein Registry Number2062123
EC Number200-596-4
Chemical Name Translation11-去氧皮质酮
Merck Number13,2917
Wiswesser Line NotationL E5 B666 OV MUTJ A E FV1Q
LabNetwork Molecule IDLN01268026
InChIInChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1
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分类

  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, H, Hormones, Progesterone, Steroid Hormones
  • {SNA} Bioactive Small Molecules, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, H, Hormones, Progesterone, Steroid Hormones, 细胞生物学
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, H, Hormones, Progesterone, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Bioactive Small Molecules,

产品应用

  • A mineralocorticoid that occurs in adrenal cortex. It acts as a precursor to Aldosterone (A514700).

相关文献及参考

  • Beil. 8 ,IV,2195
  • Bohl, C., et al.: J. Med.Chem., 47, 3765 (2004),
  • Merck 14 ,2900
  • Short: II/27C Title: Diamagnetic Susceptibility and Magnetic Anisotropy of Organic Compounds Author: Kumar, Mahendra; Gupta, Rajni Editor: Gupta, Radha Raman Source: Landolt-Börnstein, New Series Volume: II/27C Year: 2008 Keyword: diamagnetic susceptibility; magnetic anisotropy; organic compounds ISBN: 978-3-540-44734-4 (print) ISBN: 978-3-540-44736-8 (online) Internet Resource: doi:10.1007/978-3-540-44736-8 RefComment: VIII, 204 p., Hardcover RefComment: Written for: Scientists and researchers in the fields of physics, chemistry, materials science RefComment: Supplement and Revised Editon to II/16 Abstract: The volume II/27 has been divided into three subvolumes according to the classes of compounds: Subvolume A: Diamagnetic susceptibility and magnetic anisotropy of inorganic and organometallic compounds; Subvolume B: Diamagnetic susceptibility of organic compounds (Pa

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P203
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P308+P313
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P318
  • P319
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Hazard Codes Xn
RTECSHG0350000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R48 Danger of serious damage to health by prolonged exposure 长期接触有严重损害健康的危险
UN Number 2811 UN 2811 6.1/PG 2
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 7,673,1964

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 370,49,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 8750 ug/kg
SEX/DURATION            : female 7 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   JEMEAV Journal of Experimental Medicine.  (Rockefeller Univ. Press, 1230
   York Ave., New York, NY 10021)  V.1-    1896-  Volume(issue)/page/year:
   102,347,1955

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 14500 ug/kg
SEX/DURATION            : female 7 day(s) pre-mating
                          female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   JCINAO Journal of Clinical Investigation.  (Rockefeller Univ. Press, 1230
   York Ave., New York, NY 10021)  V.1-    1924-  Volume(issue)/page/year:
   41,710,1962

其他信息

  • MSDS 信息:21-Hydroxypregn-4-ene-3,20-dione(64-85-7).msds
  • 去氧皮质酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 164430025 去氧皮质酮 Desoxycorticosterone 2.5 GR 2455元 2010/06/21 164435000 去氧皮质酮 Desoxycorticosterone 500 MG 624元
  • 方法一:用其醋酸酯水解制得该品。
  • 比旋光度:184 ° (c=1, C2H5OH)
  • 用途一:羟孕酮琥酯钠的合成。
  • Acros Organics:去氧皮质酮 Desoxycorticosterone(64-85-7)
  • MOL 文件:64-85-7.mol
  • Sigma Aldrich:64-85-7(sigmaaldrich)

系列性分类


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