Cyclohexyl Chloride 氯环己烷

CAS 542-18-7 MFCD00003822

化学结构图

542-18-7
SMILES: Clc1ccccc1

化学属性

Mol. FormulaC6H11Cl
Mol. Weight118.60
Density1.0
Refractive index1.4620 to 1.4630
Boiling Point142 °C at 760 mmHg
Melting Point-44 °C
Flash Point32°C(lit.)
TSCAYes
Solubility不溶于水,溶于醇。

别名和识别编码

Chemical NameCyclohexyl Chloride
Synonym Chlorocyclohexane {LY} Chlorocyclohexane {} {LY} Chlorocyclohexane {} {} {LY} Chlorocyclohexane {} {} {} {LY} Chlorocyclohexane {} {} {} {} {LY} Chlorocyclohexane {} {} {} {} {} {LY} Chlorocyclohexane {} {} {} {} {} {} {LY} Chlorocyclohexane {} {} {} {} {} {} {} {LY} Chlorocyclohexane {} {} {} {} {} {} {} {} {LY} Chlorocyclohexane {} {} {} {} {} {} {} {} {} {LY} Chlorocyclohexane {} {} {} {} {} {} {} {} {} {} {LY} Chlorocyclohexane {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorocyclohexane {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorocyclohexane {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorocyclohexane {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorocyclohexane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorocyclohexane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorocyclohexane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlor
CAS Number542-18-7
EC Number208-806-6
Beilstein Registry Number1900796
MDL NumberMFCD00003822
PubChem Substance ID10952
Merck Number2732
Reaxys-RN1900796
Chemical Name Translation氯环己烷
LabNetwork Molecule IDLN00239523
InChIInChI=1S/C6H11Cl/c7-6-4-2-1-3-5-6/h6H,1-5H2
Canonical SMILESClC1CCCCC1
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分类

  • {SNA} Alkyl, Building Blocks, Chemical Synthesis, Halogenated Hydrocarbons, Organic Building Blocks
  • {Chemicalbook} 农药中间体: 杀螨剂中间体
  • {uni_hamburg} no charge; carbocycle; alicycle; 6RingOnly; 6ring; 1fragment

产品应用

  • 医药中间体,用于制取抗癫痫;痉挛药盐酸苯海索。也是农药三环锡的中间体和橡胶防焦剂。

相关文献及参考

  • Merck:14,2732
  • Short: II/19c
  • Merck:14,2732 Beilstein:5,21
  • Short: II/14a
  • Short: II/19b

安全信息

Signal word
GHS Symbol
WGK Germany1
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37 Wear suitable gloves 戴适当手套;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R10 Flammable 易燃
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P370+P378
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSGU8685000
Packing GroupIII
UN Number
Hazard Codes Xn
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Class3
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 27(6),24,1962

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 gm/m3/2H
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 10(1),49,1966

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 31 gm/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,36,1982

其他信息

  • MOL 文件:542-18-7.mol
  • 方法二:由环己醇经氯化而得:环己醇与30%盐酸混合搅拌,升温至85℃回流12h,温度逐渐上升至103℃左右。回流结束,冷至20℃,静置分层,放去酸水,以氯化钠饱和液及碳酸钠溶液分别洗1次,用无水氯化钙干燥,分馏,收集141-142.5℃馏分,得氯代环己烷。收率为83%。
  • Alfa Aesar:氯环己烷,98% Chlorocyc
  • 具有窒息性气味。不溶于水,水中溶解度:0.02 g/L (20°C),易溶于氯仿。能与乙醇、乙醚、丙酮和苯混溶。遇水受热分解,产生盐酸并使颜色变黄。
  • 毒性分级:低毒
  • 上游原料:盐酸 --> 氯化钠 -->
  • 储运特性:库房通风低温干燥; 与氧化剂分开存放
  • 职业标准:STEL 50 毫克/ 立方米
  • 灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
  • 急性毒性:吸入-大鼠LCL0:31000毫克/立方米;吸入-小鼠LC50:31000毫克/立方米/2小时
  • 用途一:可生
  • 可燃性危险特性:遇明火、高温、氧化剂较易燃; 燃烧产生有毒氯化物烟雾
  • 类别:易燃液体
  • MSDS 信息:环己基氯(542-18-7).msds
  • 海关编码:29035990
  • 方法一:氯代环己烷的合成方法有以下两种。 (1)环己醇氯化法 将环己醇与30%盐酸混合搅拌,升温至85℃回流12h,内温逐渐上升至103℃左右;回流结束,冷至20℃,静置分层,放去酸水,以氯化钠饱和液及碳酸钠溶液分别洗1次,用无水氯化钙干燥,分馏,收集141~142.5℃馏分,得氯代环己烷,收率为83%。 (2)环己烷氯化法 由环己烷用氯气氯化制得。 向反应器中加入环己烷,在50~90℃下通氯气,经分析氯代环己烷含量达到70%以上时即可停止反应,一般在反应2h后,环己烷的转化率可达70%以上,反应物料精馏回收未反应的环己烷。
  • 用途六:医药中间体,用于制取抗癫痫;痉挛药盐酸苯海索。也是农药三环锡的中间体和橡胶防焦剂。
  • 氯代环己烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80040226 氯代环己烷;环己基氯 100ml 105元 2011/04/16 C0153 氯环己烷 Chlorocyclohexane 500ML 552元 2011/04/16 C0153 氯环己烷 Chlorocyclohexane 25ML 140元
  • 用途四:氯代环己烷又名环己基氯,在农药上用于合成杀螨剂三环锡和三唑锡的中间体三环己基氯化锡,此外,也可用于合成医药盐酸苯海索,还可用于制防焦剂GP等产品。
  • 用途二:用于有机合成
  • 常规方法:采用铁桶或槽车装运。本品易燃。应贮存在干燥、阴凉、通风良好的仓库内。远离火种、热源。防晒、防止撞击。按易燃物品规定贮运。轻装、轻卸,防止包装破损。
  • 防护措施:环已烷具有麻醉及刺激皮肤作用,其卤代物作用更强。生产车间应有良好通风,设备应密闭。操作人员应穿戴防护用具。
  • Sigma Aldrich:542-18-7(sigmaaldrich)
  • TCI Shanghai:氯代环己烷 Chlorocyclohexane,>;98.0%(GC)(542-18-7)
  • 下游产品:2-二环己膦基-2'-(N,N-二甲胺)-联苯 --> 炔螨特 --> 三唑锡 --> 三唑锡悬浮剂 --> N-环己基硫代邻苯二甲酰亚胺 --> 三环乙基氯化锡 --> 三唑锡可湿性粉剂 --> 苯基二环己基膦 --> 环己甲醇
  • 图谱信息:氯代环己烷(542-18-7)Raman光谱 氯代环己烷(542-18-7)核磁图( 13 CNMR) 氯代环己烷(542-18-7)质谱(MS) 氯代环己烷(542-18-7)红外图谱(IR2) 氯代环己烷(542-18-7)红外图谱(IR1) 氯代环己烷(542-18-7)核磁图( 1 HNMR)

系列性分类


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