2-Sulfanylethanol 2-硫基乙醇

CAS 60-24-2 MFCD00004890

化学结构图

60-24-2
SMILES: OCCS

化学属性

Mol. FormulaC2H6OS
Mol. Weight78
Refractive index1.5000 to 1.5040
Boiling Point158°C(lit.)
Density1.114
Flash Point74°C(lit.)
TSCAYes
Melting Point< -50
Vapor Density2.69 (vs air)
Vapor Pressure1 mmHg ( 20 °C)
Solubility可溶
Appearance liquid

别名和识别编码

Chemical Name2-Sulfanylethanol
Synonym THIOGLYCOL 2-HYDROXY-1-ETHANETHIOL 2-羟基乙硫醇 1-硫代乙二醇 β-巯基乙醇 2-mercapotethanol ethylene glycol, monothio- 2-hydroxyethyl mercaptan {Chemicalbook} ß-hydroxyethanethiol {Chemica β-mercaptoethanol ?-hydroxyethanethiol 2-MERCAPTOETHANOL Thioethylene glycol ethylene thioglycol 硫代乙二醇 2-hydroxy-1-ethanethiol 2-ME Monothioglycol 2-Thioethanol BETA-MERCAPTOETHANOL 2-Mercaptoethanol 2-巯基乙醇(剧毒 05.03) β-Hydroxyethylmercaptan 2-Hydroxyethanethiol Ethylene glycol, monothio- 2-Hydroxyethylmercaptan 2-巯基乙醇 2-Hydroxyethylmercaptan β-Mercaptoethan
CAS Number60-24-2
PubChem Substance ID87560309
EC Number200-464-6
Beilstein Registry Number1(4)2428
MDL NumberMFCD00004890
Merck Number5869
Chemical Name Translation2-硫基乙醇
Wiswesser Line NotationSH2Q
LabNetwork Molecule IDLN00193337
Reaxys-RN773648
InChIInChI=1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2
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分类

  • Cell Biology, Cell Culture, Core Bioreagents, Expression and Translation, Functional Profiling of Stem Cells, General Reagents, General Stem Cell Biology, Life Science Reagents for Cell Culture, Miscellaneous Reagents and Supplements, Reagents and Supplements, Research Essentials, Stem Cell Biology
  • {SNA} BioUltr
  • {SNA} Antioxidants and Reducing Agents for Protein Stabilization, Building Blocks, Chemical Synthesis, HIS Select Supporting Products and Reagents, HIS-Select, Organic Building Blocks, Protein Modification, Reagents and Products for use with HIS-Select, Reagents for Protein Stabilization, Reagents for reduction of proteins, Reduction and Oxidation,

相关文献及参考

  • Merck 14 ,5869
  • Beil. 1 ,IV,2428
  • Aldrich MSDS 1 , 1162:C / Corp MSDS 1 (2), 2209:A / FT-IR 2 (1), 415:B / FT-IR 1 (1), 262:B / FT-NMR 1 (1), 422:B / IR-Spectra (2), 138:E / IR-Spectra (3), 154:F / NMR-Reference 2 (1), 228:B / RegBook 1 (1), 281:L / Sax 6 , 1744 / Sigma FT-IR 1 (2), 700:C / Structure Index 1 , 38:D:7 / Vapor Phase 3 , 344:C
  • Short: II/14a Title: Molecular Constants: Diamagnetic Molecules Author: Demaison, J.; Dubrulle, A.; Hüttner, W.; Tiemann, E. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: II/14a Page: 1-788 Year: 1982 Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy ISBN: 3-540-11365-7 ISBN: 978-3-540-113
  • Protective agent for preventing oxidation of thiol groups in proteins: Enzyme Assays, R. Eisenthal and M. J. Danson, Eds., OUP, Oxford (1992), p 265.
  • In the presence of BF3 etherate, reacts with carbonyl compounds to give monothioacetals (1,3-oxathiolanes): J. Org. Chem., 33, 2133 (1968). Amberlyst 15 is also effective: Synthesis, 1826 (2001), as is In(OTf)3: Synlett, 1535 (2002). 1,3-Oxathiolanes can be prepared from acid-sensitive aldehydes with LiBH4 as catalyst in acetonitrile: Synlett, 238 (2001). Cleavage can be effected, e.g. with chloramine-T: Tetrahedron Lett., 3445 (1971), isoamyl nitrite: Tetrahedron. Lett., 3561 (1978), or periodic acid: Tetrahedron Lett., 37, 4331 (1996). Selective cleavage of oxathiolanes in the presence of dithiolanes has been achieved with triphenylcarbenium tetrafluoroborate: J. Chem. Soc., Perkin 1, 542 (1972), or 4-nitrobenzaldehyde catalyzed by TMS-OTf: J. Chem. Soc. Chem. Commun., 1937 (1994). Compare 1,2-Ethanedithiol, L12865.
  • 2-Mercaptoethanol is a reagent for the specific cleavage of the N-dithiasuccinimide protecting group from amines. See Chlorocarbonyl­sulfenyl­ chloride, L06432.

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T,N
Hazard statements
  • H227 Combustible liquid 可燃液体
  • H301 Toxic if swallowed 吞食有毒
  • H301+H331
  • H310 Fatal in contact with skin 皮肤接触致命
  • H310+H330
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H318 Causes serious eye damage 严重伤害眼睛
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSKL5600000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P301+P310+P330
  • P302+P350
  • P302+P352+
  • P302+P352+P310+P361+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P311
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
UN Number 2966 UN 2966 6.1/PG 2
Risk Statements
  • R24 Toxic in contact with skin 与皮肤接触有毒
  • R22 Harmful if swallowed 吞咽有害
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R50/53
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R38 Irritating to skin 刺激皮肤
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R51/53
  • R34 Causes burns 会导致灼伤
  • R48/22
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S29 Do not empty into drains 不要排入下水道;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S57 Use appropriate containment to avoid environmental contamination 使用适当容器避免环境污染;
  • S4 Keep away from living quarters 远离生活区;
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Storage condition Air Sensitive & Hygroscopic 2-8°C
Packing GroupII
Hazard Class6.1
Restrict {} 剧毒化学品 危险品
Warnings 危化品目录(2015)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 190 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 15(2),56,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 480 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 62,237,1973

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 13200 mg/m3
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 15(2),56,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other tha

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 30 mmol/L
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   425,1,1976

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 100 mg/L
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   56,357,1976

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   ABBIA4 Archives of Biochemistry and Biophysics.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.31-    1951-  Volume(issue)/page/year:
   166,400,1975

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 77,1150,1977

其他信息

  • 蒸气压:1 mm Hg ( 20 °C)
  • 凝固点:<100℃
  • 急性毒性:口服-大鼠 LD50: 244 毫克/公斤; 口服-小鼠 LD50: 190 毫克/公斤
  • 2-巯基乙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80076927 2-巯基乙醇(剧毒) 250ml 350元 2011/08/23 80076980 2-巯基乙醇(剧毒) 250ml 351元 2011/08/23 SM625002 2-巯基乙醇(剧毒) 100ml 277元
  • 上游原料:2-氯乙醇 --> 硫氢化钠 --> 二(2-羟乙基)硫醚 --> 强碱性阴离子交换树脂
  • 海关编码:29309070
  • Acros Organics:2-巯基乙醇 2-Mercaptoethanol,extrapure,99%(60-24-2)
  • 可燃性危险特性:可燃; 受热分解有毒氧化硫气体
  • Alfa Aesar:2-巯基乙醇,98+% 2-Mercaptoethanol, 98+%(60-24-2)
  • 外观性质:水白色易流动液体,具有少许硫醇气味。
  • 用途三:作为有机合成中间体,用于农药、医药、染料、照相化学品的生产。在橡胶、纺织、塑料、涂料工业中亦可用作助剂。聚合级高纯巯基乙醇可用作氯乙烯、丙烯腈等的调取剂,以及聚合催化剂、聚合物交联剂、固化剂。该品得到美国食品药物管理局的批准,可用作丙烯腈、苯乙烯、甲基丙烯酸甲酯三元树脂制食品包装用吹塑容器时的添加剂。
  • 类别:有毒物品
  • MSDS 信息:2-巯基乙醇(60-24-2).msds
  • 职业标准:STEL 1 毫克/立方米
  • MOL 文件:60-24-2.mol
  • 储运特性:库房通风低温干燥; 与氧化剂, 食品分开储运
  • 敏感性:Air Sensitive & Hygroscopic
  • 爆炸物危险特性:与空气混合, 受热、明火可爆
  • 刺激数据:皮肤-兔子 10 毫克/24小时 重度; 眼睛-兔子 2 毫克 重度
  • Sigma Aldrich:60-24-2(sigmaaldrich)
  • 毒性分级:高毒
  • 下游产品:丙烯酸酯三元共聚物负载双硫铂配合物催化剂 --> 如氟沙星 --> 更昔洛韦 --> 萎锈灵
  • 用途二:用作增塑剂及杀虫剂,也用于染料的制造
  • 灭火剂:二氧化碳, 干粉, 砂土
  • 方法一:早期采用氯乙醇与硫氢化钠反应制得。环氧乙烷与硫化氢按摩尔比1:3.5配合,以强碱性阴离子交换树脂为催化剂,在42℃左右反应。所得粗品含量约52%,还含少量硫二甘醇(沸点282℃),较易分离获得2-巯基乙醇。
  • F:3-10-13-23
  • 图谱信息:2-巯基乙醇(60-24-2)质谱(MS) 2-巯基乙醇(60-24-2)核磁图( 13 CNMR) 2-巯基乙醇(60-24-2)红外图谱(IR1)
  • 用途一:用于合成染料、农药、医药等,在橡胶、纺织、塑料、涂料工业中可用作助剂
  • 蒸气密度:2.69 (vs air)

系列性分类