Harmine 7-甲氧基-1-甲基-9H-吡啶[3,4-b]吲哚

CAS 442-51-3 MFCD00004958

化学结构图

442-51-3
SMILES: COc1ccc2c(c1)[nH]c1c(C)nccc12

化学属性

Mol. FormulaC13 H12 N2 O
Mol. Weight212.25
Melting Point>164ºC (dec.)
TSCANo
Density1.252
Boiling Point

别名和识别编码

Chemical NameHarmine
CAS Number442-51-3
Synonym 1-Methyl-7-methoxy-?-carboline 6-Methoxyharmane 7-Methoxy-1-methyl-9H-pyrido(3,4-b)indole 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole, 1-Methyl-7-methoxy-β-carboline, Banisterin 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole; 7-Methoxy-1-methyl-9H-beta-carboline 7-methoxy-1-methyl-9H-β-carboline 7-甲氧基-1-甲基-9H-吡啶并[3,4-b]吲哚 9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl- 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl- Banisterin Banisterine Harmin Harmine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00004958
Beilstein Registry Number178813
EC Number207-131-4
PubChem Substance ID5280953
Merck Number4616
Reaxys-RN178813
Chemical Name Translation7-甲氧基-1-甲基-9H-吡啶[3,4-b]吲哚
Wiswesser Line NotationT B656 EN HMJ F1 KO1
LabNetwork Molecule IDLN01307236
InChIInChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Bioactive Small Molecules, Building Blocks, Carbazoles, Chemical Synthesis, H, Heterocyclic Building Blocks, 细胞生物学
  • Neurochemicals
  • Indole Derivatives
  • Pharmaceuticals
  • {SNA} Bioactive Small Molecules, Building Blocks, Carbazoles, Cell Biology, Chemical Synthesis, H, Heterocyclic Building Blocks
  • {SNA} Bioactive Small Molecules, Building Blocks, C13 to C27, Cell Biology, Chemical Synthesis, H, Heterocyclic Building Blocks, Indoles
  • Intermediates & Fine Chemicals
  • {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; large ring; fused rings; 5ring; 6ring; 9ring; 13ring; ether; 1fragment

产品应用

  • 中枢神经系统兴奋剂。

相关文献及参考

  • [2]. Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859.
  • [3]. Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92.
  • [4]. Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12(6):7985-91.
  • Chen, K.K., et al.: J. Pharmacol. Exp. Ther., 79, 127 (1943),
  • DiStefano, S., et al.: J. Pharmacol. Exp. Ther., 174, 456 (1970),
  • Merck: 14,4616
  • Merck: 14,4616 Beilstein:23(2)348
  • Short: EINECS
  • Short: III/5a
  • [1]. Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32.

安全信息

WGK Germany3
RTECSUV0175000
GHS Symbol
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P304+P340+P312
  • P305+P351+P338
  • P308+P311
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H302+H312+H332
Signal word Danger
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36 Irritating to eyes 刺激眼睛
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
Hazard Codes Xn
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - tremor
   Gastrointestinal - nausea or vomiting
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 129,133,1928

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   NEPHBW Neuropharmacology.  (Pergamon Press Ltd., Headington Hill Hall,
   Oxford OX3 OBW, UK) V.9-    1970-  Volume(issue)/page/year: 10,15,1971

TY

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   9,37,1936

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   inform

TYPE OF TEST

Storage condition +4°C 4 4℃

其他信息

  • 不溶于水。

系列性分类


相关产品推荐