β-Propiolactone β-丙内酯

CAS 57-57-8 MFCD00005169

化学结构图

57-57-8
SMILES: O=C1CCO1

化学属性

Mol. FormulaC3H4O2
Mol. Weight72.06
Refractive index1.4110 to 1.4150
Boiling Point162 °C at 760 mmHg
Density1.146
Melting Point-33 °C
Flash Point70°C
TSCAYes
Solubility溶于水,可混溶于乙醇。

别名和识别编码

Chemical Nameβ-Propiolactone
CAS Number57-57-8
Synonym Propiolactone {LY} Propiolactone {} {LY} Propiolactone {} {} {LY} Propiolactone {} {} {} {LY} Propiolactone {} {} {} {} {LY} Propiolactone {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID2365
EC Number200-340-1
MDL NumberMFCD00005169
Beilstein Registry Number17(3/4)41
Reaxys-RN1360
Merck Number7820
Chemical Name Translationβ-丙内酯
Wiswesser Line NotationT4OVTJ
LabNetwork Molecule IDLN01313535
InChIInChI=1S/C3H4O2/c4-3-1-2-5-3/h1-2H2
Canonical SMILESO=C1OCC1
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分类

  • Building Blocks, Carbonyl Compounds, Chemical Synthesis, Lactones, Organic Building Blocks
  • {uni_hamburg} no charge; oxygen heterocycle; alicycle; 4ring; ester; lactone; 1fragment
  • {SNA} Building Blocks, Carbonyl Compounds, Chemical Synthesis, Lactones, Organic Building Blocks

产品应用

  • 作药物、树脂和纤维改性剂的中间体,也用作杀菌消毒剂和疫苗灭活剂,用于血浆和疫苗的杀菌。衍生物β-巯基丙酸是PVC稳定剂和医药的原料。

相关文献及参考

  • Merck:14,7820 Beilstein:17(3/4)41
  • Short: II/27C
  • Cramer, G., et al.: Food Cosmet. Toxicol., 16, 255 (1978),
  • Merck:14,7820
  • Short: II/14a
  • Short: II/4

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T+
Hazard statements
  • H227 Combustible liquid 可燃液体
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H330 Fatal if inhaled 吸入致命
  • H350 May cause cancer 可能致癌
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSRQ7350000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P203
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P302+P350
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P308+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P316
  • P318
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P333+P313
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Risk Statements
  • R26 Very toxic by inhalation 吸入极毒
  • R45 May cause cancer 可能致癌
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
UN Number UN 3382 6.1/PG 1 3382
Storage condition 2-8°C {LY} 2-8°C <0°C <;0 Moisture Sensitive {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Packing GroupI
Hazard Class6.1
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   10,357,1956

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg/25W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   15,85,1961

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 ppm/6H/30D-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 79,285,1987

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3050 mg/kg/61W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volum

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 405 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,911,1979

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 ppm/6H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
   Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
   Industrial Hygienists, Inc., 1986  Volume(issue)/page/year: 5,497,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 uL/plate
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,387,1981

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 8300 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 192,239,1987

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 250 ppm
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 6,189,1984

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 340 nmol/plate
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 79,5971,1982

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 110 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,4368,1981

{

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 200 ug/L
REFERENCE :

其他信息

  • 下游产品:丙烯酸正丁酯 --> 丙烯酸乙酯 --> 6-溴-3,4-二氢-4-羟基-2H-苯并吡喃 --> 3-巯基丙酸 --> N,N-二甲基,对十八烷基苯磺酰胺丙基铵基丙磺酸盐 --> 6-溴-4-二氢色原酮 --> N,N-二羟乙基,N-对十八烷基苯磺酰胺丙基铵基丙磺酸盐
  • 可燃性危险特性:易燃; 火场释放辛辣刺激烟雾; 在水中迅速水解
  • Alfa Aesar:β-丙内酯,97% beta-Propiolactone, 97%(57-57-8)
  • 方法一:由乙酸裂解制得乙烯酮,再与甲醛按摩尔比3:1配合,以氯为稀释剂,在BF3催化剂作用下气相缩合或液丁缩合而成。
  • 爆炸物危险特性:与空气混合可爆
  • MSDS 信息:β-丙内酯(57-57-8).msds
  • 用途一:用作药物、树脂和纤维改性剂的中间体,也用作杀菌消毒剂,用于血浆和疫苗的杀菌。衍生物β-巯基丙酸是PVC稳定剂和医药的原料。
  • 灭火剂:二氧化碳, 干粉
  • 职业标准:TWA 1.5 毫克/立方米
  • 类别:有毒物质
  • 急性毒性:吸入-大鼠 LC50: 25 ppm/6小时; 腹腔-小鼠 LD50: 405 毫克/公斤
  • 上游原料:乙醚 --> 乙腈 --> 四氯化碳 --> 环己烷 --> 挥发性漆稀释剂 --> 1,8-二氮杂双环[5.4.0]十一碳-7-烯 --> 氧化二乙酰丙酮合钒 --> 1,3-丙二醇 --> 3-溴丙酸
  • 能与丙酮、乙醚和氯仿混溶,在水中溶解为37%,其水溶解迅速全部水解。
  • 用途二:作药物、树脂和纤维改性剂的中间体,也用作杀菌消毒剂,用于血浆和疫苗的杀菌。衍生物β-巯基丙酸是PVC稳定剂和医药的原料。
  • 毒性分级:高毒
  • 存储注意事项:光敏感;氩气保护
  • Sigma Aldrich:57-57-8(sigmaaldrich)
  • TCI Shanghai:β-丙内酯 beta-Propiolactone,>;95.0%(GC)(T)(57-57-8)
  • 储运特性:库房低温, 通风, 干燥; 防潮
  • beta-丙内酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 H0168 β-丙内酯 beta-Propiolactone 25G 3300元 2014/06/02 H0168 β-丙内酯 beta-Propiolactone 5G 920元 2010/06/21 269041000 beta-丙内酯 beta-Propiolactone 98%, pure 100 ML 12585元
  • 外观性质:无色液体。
  • Acros Organics:beta-丙内酯 beta-Propiolactone, pure, 98%(57-57-8)
  • MOL 文件:57-57-8.mol

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