5,5-Diphenylhydantoin 5,5-二苯基海因

CAS 57-41-0 MFCD00005264

化学结构图

57-41-0
SMILES: O=C1NC(=O)C(c2ccccc2)(c2ccccc2)N1

化学属性

Mol. FormulaC15H12N2O2
Mol. Weight252
Melting Point293-295 °C(lit.)
TSCANo
Flash Point11 °C
SolubilityDMSO 50 mg/mL Water <1 mg/mL Ethanol 13 mg/mL

别名和识别编码

Chemical Name5,5-Diphenylhydantoin
Synonym 2,4-Imidazolidinedione, 5,5-diphenyl- 5,5-DIPHE 5,5-DIPHENYLHYDANTHOIN 5,5-DIPHENYLHYDANTOIN 5,5-Diphenyl-2,4-imidazolidinedione 5,5-Diphenylhydantoin 5,5-Diphenylimidazolidin-2,4-dione 5,5-Dwufenylohydantoina 5,5-diphenyl-hydantoi 5,5-diphenylimidazolidine-2,4-dione 5,5-二苯基乙内酰脲 5,5-二苯基海因 5,5-联苯基乙内酰脲 苯妥英 5,5-二苯基海因;二苯尿囊素;5,5-联苯基乙内酰脲;二苯基乙內酰脲5,5-二苯基乙内酰脲 5,5-联苯基乙内酰脲 5,5-联苯基乙内酰脲 苯妥英 5,5-联苯基乙内酰脲, 99% Aleviatin Antisacer Causoin Citrullamon Citrulliamon Comital Comitoina DIPHENYLHYDANTOIN DPH Dantoina Dantoinal klinos Dantoine Denyl Di-Hydan Di-Lan {Pu
MDL NumberMFCD00005264
CAS Number57-41-0
Beilstein Registry Number24,410
EC Number200-328-6
PubChem Substance ID1775
Merck Number7322
Chemical Name Translation5,5-二苯基海因
Reaxys-RN384532
Wiswesser Line NotationT5MVMV EHJ ER& ER
LabNetwork Molecule IDLN00221394
InChIInChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
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分类

  • {SNA} Anticonvulsants, Bioacti
  • {SNA} Anticonvulsan
  • {SNA} Analytical Standards,
  • {SNA} Analy
  • {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Analytical Standards, Analytical/Chromatography,
  • {SNA} Anticonvulsants, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY, Neurobiology, Neuroscience, Pharmacologicals
  • {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Additional Standards, Analytical Standards, Chromatography, EP Standards, EP Standards P - R, Pharmaceutical Standards, Pharmacopeia & Metrological Institutes Standards, Phenytoin, 分析/色谱
  • {SNA} Anticonv

安全信息

GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P310
  • P301+P312
  • P301+P312+P330
  • P302+P352
  • P307+P311
  • P308+P311
  • P308+P313
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P333+P313
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H331 Toxic if inhaled 吸入中毒
  • H350 May cause cancer 可能致癌
  • H351 Suspected of causing cancer 怀疑致癌
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H370 Causes damage to organs 导致器官损伤
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
WGK Germany3
Signal word Danger
Personal Protective Equipment Eyeshields, Gloves, type P2 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSMU1050000
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S24 Avoid contact with skin 避免皮肤接触;
  • S37 Wear suitable gloves 戴适当手套;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S7 Keep container tightly closed 保存在严格密闭容器中;
Risk Statements
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R45 May cause cancer 可能致癌
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R22 Harmful if swallowed 吞咽有害
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R11 Highly flammable 非常易燃
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Hazard Codes T T,Xn,F
Packing GroupII
Hazard Class6.1(b)
Storage condition 储存温度-20°C 2-8°C
UN Number 2811
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1620 mg/kg

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 6023 mg/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Skin and Appendages - tumors
REFERENCE :
   AJDEBP Australasian Journal of Dermatology.  (Australasian College of
   Dermatologists, 271 Bridge Rd., Glebe, N.S.W., Australia)  V.9-    1967-
   Volume(issue)/page/year: 22,28,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 52560 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-404,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   26,619,1966

TYPE OF TEST            : TDLo - Lowest published toxic

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1620 mg/kg
                          female 1-39 week(s) after conception
TOXIC

{hazard_com}

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1300 mg/kg
TOXIC EFFECTS :
   Blood - other changes
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   69,557,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

{h

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - hallucinations, distorted perceptions
   Behavioral - ataxia
REFERENCE :
   AEMED3 Annals of Emergency Medicine.  (American College of Emergency
   Physicians, 1125 Executive Circle, Irving, TX 75038)
   Volume(issue)/page/year: 16,1387,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 30,477,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 106 mg/kg/2W-I
TOXIC EFFECTS :
   Brain and Coverings - encephalitis
   Behavioral - hallucinations, distorted perceptions
   Behavioral - ataxia
REFERENCE :
   JCGADC Journal of Clinical Gastroenterology.  (Raven Press, 1185 Ave. of the
   Americas, New York, NY 10036)  V

{h

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 100 mg/L
REFERENCE :
   TIVIEQ Toxicology In Vitro.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.1-   1987-  Volume(issue)/page/year: 2,103,1988

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 100 ug/L
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 109,961,1971

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 40 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 204,623,1988

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 1260 mg/kg/6W
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 9,387,1988

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 mg/L
REFERENCE :
   VIRLAX Virology.  (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
   V.1-    1955-  Volume(issue)/page/year: 99,257,1979

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 1620 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,481,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 1080 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,702,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 1365 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Effects on Newborn - physical
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   89,662,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 3675 mg/kg
SEX/DURA

其他信息

  • 5,5-二苯基海因
  • 苯妥英价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D0894 5,5-二苯基乙内酰脲 5,5-Diphenylhydantoin 25G 156元 2014/06/02 D0894 5,5-二苯基乙内酰脲 5,5-Diphenylhydantoin 500G 1380元 2010/06/21 171735000 苯妥英 5,5-Diphenylhydantoin 99+% 500 GR 1488元
  • 海关编码:29332100
  • TCI Shanghai:5,5-二苯基乙内酰脲 5,5-Diphenylhydantoin,>;99.0%(T)(57-41-0)
  • MOL 文件:57-41-0.mol
  • 图谱信息:苯妥英(57-41-0)红外图谱(IR1) 苯妥英(57-41-0)核磁图( 1 HNMR) 苯妥英(57-41-0)红外图谱(IR2) 苯妥英(57-41-0)核磁图( 13 CNMR) 苯妥英(57-41-0)质谱(MS)
  • 用途一:用作抗癫痫药、抗心律失常药
  • 上游原料:苯甲醛
  • 下游产品:2,4,6-三氟苯酚
  • Alfa Aesar:5,5-联苯基乙内酰脲,99% 5,5-Diphenylhydantoin, 99%(57-41-0)
  • Sigma Aldrich:57-41-0(sigmaaldrich)
  • Acros Organics:5,5-二苯基海因 5,5-Diphenylhydantoin, 99+%(57-41-0)
  • MSDS 信息:5,5-Diphenyl-2,4-imidazolidinedione(57-41-0).msds

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