Bilirubin 胆红素

CAS 635-65-4 MFCD00005499

化学结构图

635-65-4
SMILES: C=CC1=C(C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(C)=C4C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O

化学属性

Mol. FormulaC33 H36 N4 O6
Mol. Weight584.662
TSCAYes
Melting Point>300
SolubilitySoluble in chloroform (10 mg/ml), benzene, chlorobenzene, carbon disulfide, alkaline solutions, aqueous acid, ethanol (slightly), and ether (slightly). Insoluble in water.
Density1.374
Stability对光和热敏感
Appearance powder
Refractive index1.72
Boiling Point925.16°C/760mmHg

别名和识别编码

Chemical NameBilirubin
MDL NumberMFCD00005499
PubChem Substance ID5280352
Beilstein Registry Number74376
CAS Number635-65-4
EC Number211-239-7
Merck Number1218
Synonym ,13,18-tetramethyl-1,19-dioxo- 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-biline-12-dipropionicacid 12-dipropanoicacid,2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8 18-divinyl-19-dioxo-3 2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid 21H-BILINE-8,12-DIPROPANOIC ACID,2,17-DIETHENYL-1,10,19,22,23,24-HEXAHYDRO-3,7,13,18-TETRAMETHYL-1,19-DIOXO- 21h-biline-8,12-dipropanoicacid,2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7 BILIRUBIN BILIRUBIN (ALPHA) BILIRUBIN (EX PIG) BILIRUBIN CALIBRATOR, TOTAL & DIRECT BILIRUBIN CONTROL, TOTAL AND DIRECT*ELEVATED BILIRUBIN LIN-TROL TOTAL & DIRECT BILIRUBIN MIXED ISOMERS BILIRUBIN STANDARD Bilirubin {LY
Chemical Name Translation胆红素
Wiswesser Line NotationT5VMYTJ D1 E1U1 CU1- ET5MYTJ C2VQ D1 BU1- ET5MYTJ C1D2VQ BU1- ET5MVTJ C1 D1U1
LabNetwork Molecule IDLN00199597
InChIInChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
Canonical SMILESCC(C(N/1)=O)=C(C=C)C1=C\C2=C(C)C(CCC(O)=O)=C(CC3=C(CCC(O)=O)C(C)=C(/C=C4NC(C(C=C)=C\4C)=O)N3)N2
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Antioxidants and Cytoprotectants, Application Index, Bilirubin, Cell Stress, Core Bioreagents, Enzyme Inhibitors, Nitric Oxide and Cell Stress, Plasma & Blood Proteins, Plasma, Blood, and Related Proteins and Reagents, Research Essentials, Serum Proteins, Serum Proteins and Related Enzymes, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物, 酶、抑制剂和底物
  • {SNA} Bilirubin, Plasma & Blood Proteins, Plasma, Blood, and Related Proteins and Reagents, 生化试剂, 蛋白质及衍生物
  • {SNA} Application Index, Bilirubin, Core Bioreagents,

产品应用

  • 抗氧剂,保护膜磷脂免受过氧化氢自由基的氧化。即使在纳摩尔浓度也能保护神经元免受氧化损害。

相关文献及参考

  • [2]. Mölzer C, et al. Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: a mechanism for antigenotoxic action against a model epoxide. J Nat Prod. 2013 Oct 25;76(10):1958-65.
  • Costanzo, J.A., et al., Evaluation Of Polymer Matrices For An Adsorptive Approach To Plasma Detoxification. Biomaterials 31 , 2857-65, (2010) 摘要
  • Dore, S., et al., Bilirubin formed by activation of heme oxygenase-2 protects neurons against oxidative stress injury. Proc. Natl. Acad. Sci. U. S. A. 96 , 2445, (1999) 摘要
  • Merck: 14,1218
  • Merck: 14,1218 Beilstein: 26,IV,3268
  • Minetti, M., et al., Bilirubin is an effective antioxidant of peroxynitrite-mediated protein oxidation in human blood plasma. Arch. Biochem. Biophys. 352 , 165, (1998) 摘要
  • Roelandt, P., et al., Differentiation Of Rat Multipotent Adult Progenitor Cells To Functional Hepatocyte-like Cells By Mimicking Embryonic Liver Development. Nat. Protoc. 5 , 1324-36, (2010) 摘要
  • Utha

安全信息

RTECSDU3038000
WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition -20°C -20°C 避光保存。 -20℃ 0-10 0-10°C 储存温度-20°C
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Signal word Warning
GHS Symbol
Risk Statements
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
Hazard Codes Xn
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
REFERENCE :
   ESKHA5 Eisei Shikenjo Hokoku.  Bulletin of the Institute of Hygienic
   Sciences.  (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
   Setagaya-ku, Tokyo 158, Japan)  V.1-    1886-  Volume(issue)/page/year:
   (103),29,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >15 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ESKHA5 Eisei Shikenjo Hokoku.  Bulletin of the Institute of Hygienic
   Sciences.  (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
   Setagaya-ku, Tokyo 158, Japan)  V.1-    1886-  Volume(issue)/page/year:
   (103),29,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 175 mg/kg
SEX/DURATION            : female 9-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 127,497,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 25 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 127,497,1977

其他信息

  • 所属类别二:生物化学品: 脂类: 其他
  • 参考质量标准二:部颁标准 指标名称 指标 指标名称 指标 含量(C33H36N4O6)/% ≥90.0%/干燥失重/% ≤2.0
  • 参考质量标准一:含量≥90%。
  • 用途:用于人工牛黄中胆红素的测定,人工牛黄的制备及生化研究。
  • 稳定性:Stable. Refrigerate.
  • 图谱信息:胆红素(635-65-4)红外图谱(IR2) 胆红素(635-65-4)质谱(MS) 胆红素(635-65-4)红外图谱(IR1) 胆红素(635-65-4)核磁图( 1 HNMR)
  • MOL 文件:635-65-4.mol
  • color:orange
  • RTECS号:DU3038000
  • 生产方法:新鲜牛胆汁或猪胆汁经生石灰作用,生成胆红素钙盐,再用盐酸酸化,氯仿溶剂提取制得。
  • 海关编码:29339990
  • Bilirubin is a principal pigment of bile and one of the major end products of hemoglobin decomposition. It contains conjugated double bonds and reactive hydrogen atoms. Serves as a physiological antioxidant. Reported to cross the blood-brain barrier and exert significant antioxidant effects in the brain. This product corresponds to the unconjugated form. Extinction coefficient (454 nm, CHCl3):59,100-62,300 M-1cm-1.
  • 所属类别一:生物化学品: 生化试剂: 核糖、核苷酸及其他类
  • 对光敏感。加热色渐渐变黑而不熔融。溶于苯、氯仿、氯苯、二硫化碳、酸和碱,微溶于乙醇和乙醚,几乎不溶于水。浅绿色溶液在紫外线下显红色荧光。干燥时稳定,氯仿溶液在暗处稳定,碱溶液易氧化。
  • 胆红素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 LA1752201 胆红素(+4`C) 1g 1378元 2011/04/16 B0460 胆红素 Bilirubin 100MG 229元 2011/04/16 B0460 胆红素 Bilirubin 1G 1140元
  • F:8
  • EPA化学物质信息:21H-Biline-8,12- dipropanoic acid, 2,17-diethenyl-1,10,19,22, 23,24-hexahydro-3,7,13,18- tetramethyl-1,19-dioxo-(635-65-4)

系列性分类


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