安全信息
RTECS | DD6521000 |
GHS Symbol
Precautionary statements | |
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
|
Hazard statements | |
- H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
- H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
|
WGK Germany | 3 |
Signal word |
Warning |
Personal Protective Equipment |
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
Hazard Codes |
Xn |
Risk Statements | |
- R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
|
Safety Statements | |
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
|
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 39530 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary,
Developmental Therapeutics Program. (Bethesda, MD 20205)
Volume(issue)/page/year: JAN1986
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 35 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 210,313,1989
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 500 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 190,137,1987
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intravenous
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 80 mg/kg
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,6,1989
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Mammal - species unspecified
DOSE/DURATION : 2 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 201,423,1988
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 80 mg/kg
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, U
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 1 mg/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8.
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TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 10 mg/kg
SEX/DURATION : female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 210,313,1989