Piperonylbutoxide 胡椒基丁醚

CAS 51-03-6 MFCD00005842

化学结构图

51-03-6
SMILES: CCCCOCCOCCOCc1cc2c(cc1CCC)OCO2

化学属性

Mol. FormulaC19H30O5
Mol. Weight338
Density1.059
Refractive index1.4960 to 1.5010
Boiling Point195°C/2mmHg(lit.)
Flash Point171°C(lit.)
Solubility<0.1 G/100 ML AT 18 ºC
TSCAYes

别名和识别编码

Chemical NamePiperonylbutoxide
CAS Number51-03-6
Synonym 5-(2-(2-丁氧基乙氧基)乙氧甲基)-6-丙基-1,3-苯并二氧杂戊环 A-[2-(2-BUTOXYETHOXY)ETHOXY]-4,5-METHYLENEDIOXY-2-PROPYLTOLUENE 3,4-亚甲二氧基-6-正丙基苄基正丁基二缩乙二醇醚 5-Propyl-4-(2,5,8-trioxa-dodecyl)-1,3-benzodioxol alpha-(2-(2-Butoxyethoxy)ethoxy)-4,5-me 3,4-Methylendioxy-6-propylbenzyl-n-butyl-diaethylenglykolaether 5-[2-(2-Butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole alpha-(2-(2-n-Butoxyethoxy)-ethoxy)-4,5-methylenedioxy-2-propyltoluene 1,3-Benzodioxole, 5-((2-(2-butoxyethoxy)ethoxy)methyl)-6-propyl- Butoxide (synergist) BUTOXIDE(R) 6-(Propylpiperonyl)-butyl carbityl ether BUTACIDE(R) 增效醚/胡椒基丁醚 3,4-亚甲二氧基-6-(丁氧乙氧乙氧甲基)丙苯
EC Number200-076-7
Beilstein Registry Number288063
MDL NumberMFCD00005842
PubChem Substance ID5794
Chemical Name Translation胡椒基丁醚
Reaxys-RN288063
Merck Number7476
Wiswesser Line NotationT56 BO DO CHJ G3 H1O2O2O4
LabNetwork Molecule IDLN00194126
InChIInChI=1S/C19H30O5/c1-3-5-7-20-8-9-21-10-11-22-14-17-13-19-18(23-15-24-19)12-16(17)6-4-2/h12-13H,3-11,14-15H2,1-2H3
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分类

  • {SNA} Additional Standards, Analytical Standards, EPA, Endocrine Disruptors (Draft), Method and Regulation Specific, N-P, Other Pesticide Standards, 农残和代谢标准品, 分析/色谱, 按照字母排序
  • {SA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds, Protected Alcohols/Phenols
  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds, Protected Alcohols/Phenols
  • {SNA} Alphabetical Index of Analytical Standards,
  • {SNA} Additional Pesticide Standards, Additional Standards, Analytical Standards, EPA, Endocrine Disruptors (Draft), Method and Regulation Specific,

产品应用

  • 本品能提高除虫菊素和多种拟除虫菊酯、鱼滕酮和氨基甲酸酯类杀虫剂的杀虫活性。

相关文献及参考

  • Gaines, T. B., et al.; Toxicol. Appl. Pharmacol., 14, 515 (1969),
  • Merck: 14,7476 Beilstein: 19,IV,779
  • Merck: 14,7476

安全信息

Signal word
GHS Symbol
WGK Germany3
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Risk Statements
  • R24 Toxic in contact with skin 与皮肤接触有毒
  • R51/53
  • R50/53
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P405 Store locked up. 上锁保管。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P302+P350
  • P302+P352+P310+P361+P364
Hazard statements
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H331 Toxic if inhaled 吸入中毒
  • H310 Fatal in contact with skin 皮肤接触致命
Personal Protective Equipment Eyeshields, Gloves
RTECSXS8050000
Hazard Codes
UN Number UN3082 2810
Packing GroupII
Hazard Class6.1
Storage condition 0-6°C
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 262 gm/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 124,95,1997

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 526 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   22,293,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 263 gm/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   68,467,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1000 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB223-159

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 7500 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AJTMAQ American Journal of Tropical Medicine.  (Baltimore, MD)  V.1-31,
   1921-51.  For publisher information, see AJTHAB.  Volume(issue)/page/year:
   27,339,1947

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 32,605,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,288,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCOC** Pesticide Chemicals Official Compendium, Association of the American
   Pesticide Control Officials, Inc., 1966.  (Topeka, KS)
   Volume(issue)/page/year: -,9

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Human Embryo
DOSE/DURATION           : 50 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 344,27,1995

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 500 ug/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 4,291,1983

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 30 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   12,85,1988

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 250 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 368,249,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2130 mg/kg
SEX/DURATION            : female 11-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TIHEEC Toxicology and Industrial Health.  (Princeton Scientific Pub. Co.,
   POB 2155, Princeton, NJ 08540)  V.1-    1985-  Volume(issue)/page/year:
   11,175,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3600 mg/kg
SEX/DURATION            : female 11-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 19,340,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 89600 ug/kg
SEX/DURATION            : multigeneration
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.

其他信息

  • 增效醚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 P0458 胡椒基丁醚 Piperonyl Butoxide 500G 1330元 2011/04/16 P0458 胡椒基丁醚 Piperonyl Butoxide 25G 187元 2010/06/21 334161000 增效醚 Piperonyl butoxide 90%, tech. 100 ML 454元
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 类别:农药
  • 毒性分级:中毒
  • 方法一:黄樟素在镍催化下进行高压加氢,得氢氧化黄樟素,经氯甲基化后与丁基卡必醇缩合,再经减压分馏、精制而得。
  • 用途三:本品能提高除虫菊素和多种拟除虫菊酯、鱼滕酮和氨基甲酸酯类杀虫剂的杀虫活性。
  • MOL 文件:51-03-6.mol
  • 上游原料:多聚甲醛 --> 黄樟素 --> 二乙二醇丁醚 --> 黄樟油
  • Acros Organics:增效醚/胡椒基丁醚 Piperonyl butoxide, tech., 90%(51-03-6)
  • 图谱信息:增效醚(51-03-6)核磁图( 13 CNMR) 增效醚(51-03-6)核磁图( 1 HNMR) 增效醚(51-03-6)质谱(MS) 增效醚(51-03-6)红外图谱(IR1)
  • 增效醚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P0458 胡椒基丁醚 Piperonyl Butoxide 500G 1160元 2014/06/02 P0458 胡椒基丁醚 Piperonyl Butoxide 25G 151元 2010/06/21 334161000 增效醚 Piperonyl butoxide 90%, tech. 100 ML 454元
  • MSDS 信息:胡椒基丁醚(51-03-6).msds
  • 灭火剂:干粉、泡沫、砂土
  • 用途二:杀虫剂。 用于杀死米、麦、豆类等谷物在贮藏期间产生的虫,如谷象虫。常与杀虫剂除虫菊素合用,形成络合物以起增效作用。单用除虫菊素的杀虫(家蝇为例)死亡率为46%,如使用与本品合用的制剂(30mg+400mg),则杀死率可达92%。通常将本品按10倍于除虫菊素的量与其混合,配制成0.05%~0.2%乳剂或粉剂使用。 施用本品后,其残效性约可保持1~10个月的防虫效果。 按日本规定,可用于谷类,限量为0.024g/kg(以本品计)。 复配型杀虫剂的实例:本品1.2%,除虫菊素0.08%,矿物性物质98.72%(60kg谷物约拌和、喷雾使用120g)。
  • 外观性质:淡黄色至淡褐色透明油状液体。
  • 急性毒性:口服- 大鼠 LD50: 6150 毫克/ 公斤; 口服- 小鼠 LD50: 2600 毫克/ 公斤
  • TCI Shanghai:胡椒基丁醚 Piperonyl Butoxide,>;90.0%(GC)(51-03-6)
  • 不溶于水,可溶于包括矿物油和二氯甲烷在内的大多数有机溶剂,水溶性<0.1g/100mL。对光和紫外线稳定,抗水解。本品无腐蚀性, 但在铁的容器内能变化。
  • Sigma Aldrich:51-03-6(sigmaaldrich)
  • 用途一:用作杀虫增效剂

系列性分类


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