2-Amino-4,6-Dichloropyrimidine 2-氨基-4,6-二氯嘧啶

CAS 56-05-3 MFCD00006090

化学结构图

56-05-3
SMILES: Nc1nc(Cl)cc(Cl)n1

化学属性

Mol. FormulaC4H3Cl2N3
Mol. Weight163.99
Melting Point219-222°C
TSCAT
Density1.606
Appearance 纯品为白色结晶，工业品为淡黄色固体，m.p.223～225℃，受热易升华，不溶于水，溶于丙酮、二氯乙烷及热甲苯。
Boiling Point348.5°C at 760 mmHg

别名和识别编码

Chemical Name2-Amino-4,6-Dichloropyrimidine
CAS Number56-05-3
Alfabeta NameAMINODICHLOROPYRIMIDINE 246---,
MDL NumberMFCD00006090
Synonym 2-Amino-4,6-dichloropyrimidine {LY} 2-Amino-4,6-dichloropyrimidine {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichlorop
EC Number200-253-9
Beilstein Registry Number25(3/4)2123
PubChem Substance ID87562909
Reaxys-RN118454
Chemical Name Translation2-氨基-4,6-二氯嘧啶
LabNetwork Molecule IDLN00121619
InChIInChI=1S/C4H3Cl2N3/c5-2-1-3(6)9-4(7)8-2/h1H,(H2,7,8,9)
Canonical SMILESClC1=CC(Cl)=NC(N)=N1
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分类

  • Building Blocks, C4 to C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyrimidines
  • {SNA} Building Blocks, C4 to C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyrimidines
  • {uni_hamburg} no charge; nitrogen heterocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {Chemicalbook} 农药中间体: 除草剂中间体: 磺酰脲类除草剂

产品应用

  • 用于合成苄磺隆和氯嘧磺隆,四唑嘧磺隆、吡嘧磺隆（NC-311）等。

相关文献及参考

  • Beilstein: 25,IV,2123
  • Short: EINECS
  • Short: III/5a

安全信息

Warnings IRRITANT
Signal word
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
RTECSUV6260485
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0892-10223

Storage condition -20°C, sealed storage, away from moisture and light {LY} -20°C, sealed storage, away from moisture and light {} {LY} -20°C, sealed storage, away from moisture and light {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C

其他信息

  • 用途一:重要的医药中间体
  • 图谱信息:2-氨基-4,6-二氯嘧啶(56-05-3)核磁图( 1 HNMR) 2-氨基-4,6-二氯嘧啶(56-05-3)质谱(MS) 2-氨基-4,6-二氯嘧啶(56-05-3)红外图谱(IR1)
  • 用途三:2-氨基-4，6-二氯嘧啶是制备2-氨基-4，6-二甲氧基嘧啶的中间体，可用于生产磺酰脲类除草剂，如苄嘧磺隆、吡嘧磺隆、烟嘧磺隆等。
  • Sigma Aldrich:56-05-3(sigmaaldrich)
  • Alfa Aesar:2-氨基-4,6-二氯嘧啶,99% 2-Amino-4,6-dichloropyrimidine, 98%(56-05-3)
  • 用途二:用于合成氯嘧磺隆除草剂
  • 海关编码:29335995
  • 用途五:用于合成苄磺隆和氯嘧磺隆,四唑嘧磺隆、吡嘧磺隆（NC-311）等。
  • TSCA:T
  • MSDS 信息:2-Amino-4,6-dichloropyrimidine(56-05-3).msds
  • TCI Shanghai:2-氨基-4,6-二氯嘧啶 2-Amino-4,6-dichloropyrimidine,>;97.0%(T)(56-05-3)
  • 用途四:用于合成苄磺隆和氯嘧磺隆。
  • 方法一:其制备方法是在反应釜中加入2-氨基-4，6-二羟基嘧啶、三氯氧磷和二氯乙烷，加热到82℃，将三乙胺和二氯乙烷溶液滴加到反应液中，滴加时间1 h以上，然后将混合物在82～84℃回流2h，脱溶，加水水解，过滤，水洗，干燥得成品。
  • F:10
  • MOL 文件:56-05-3.mol
  • 2-氨基-4,6-二氯嘧啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A1456 2-氨基-4,6-二氯嘧啶 2-Amino-4,6-dichloropyrimidine 25G 817元 2014/06/02 A1456 2-氨基-4,6-二氯嘧啶 2-Amino-4,6-dichloropyrimidine 500G 7450元 2014/06/02 A1110 2-氨基-4,6-二氯嘧啶 2-Amino-4,6-dichloropyrimidine 25G 993元
  • 上游原料:三乙胺 --> 4,6-二羟基嘧啶
  • 检测方法:HPLC,NMR
  • 下游产品:苄嘧磺隆 --> 2-氨基-4,6-二甲氧基嘧啶 --> 2-氨基-4-羟基-6-肼基嘧啶
  • Acros Organics:2-Amino-4,6-dichloropyrimidine, tech., 95%(56-05-3)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrimidines 嘧啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Pyrimidines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Pyrimidines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrimidines 嘧啶
  5. C4 to C5 - Pyrimidines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Pyridines
  1. C9 to C46