5-butylpicolinic acid 5-丁基吡啶甲酸

CAS 536-69-6 MFCD00006298

化学结构图

536-69-6
SMILES: CCCCc1ccc(C(=O)O)nc1

化学属性

Mol. FormulaC10H13NO2
Mol. Weight179.22
Melting Point97.0 to 101.0 deg-C
Solubilityethanol: 50 mg/mL, clear, faintly yellow

别名和识别编码

Chemical Name5-butylpicolinic acid
Synonym FURASIC ACID 5-BUTYL-2-PYRIDINECARBOXYLIC ACID 5-butylpyridine-3-carboxylic acid 5-N-BUTYLPICOLINIC ACID Butylpicolinic acid 芙莎酸 5-n-butylpyridine-2-carboxylicacid 镰孢菌酸 FUSARIC ACID FUSARIC ACID 99% 5-N-BUTYL-2-PICOLINIC ACID 5-butyl-2-pyridinecarboxylicaci 5-Butyl-2-pyridinecarboxylic acid 5-Buthyl picolinic acid FUSARIC ACID DOPAMINE B-HYDROXYLAS fusaric acid from gibberella fujikuroi 5-BUTYLPYRIDINE-2-CARBOXYLIC ACID 萎蔫酸 5-n-Butylpyridine-2-carboxylic acid 5-Butylpyridine-2-carboxylic acid 5-Butylpicolinic acid 5-丁吡啶二甲酸 Picolinic acid, 5-butyl- Fusarinic acid 5-丁基-2-吡啶甲酸 fusarinicacid Fusaric Fusaric acid 5-BUTYLPICOLINIC ACID 5-丁基-2-吡啶羧酸 镰刀菌酸 丁吡啶甲酸 5-Butylpyridine-2-carboxylic acid 5-Butylpicolinic acid
MDL NumberMFCD00006298
PubChem Substance ID3442
Beilstein Registry Number9(4)953
CAS Number536-69-6
EC Number208-643-0
Chemical Name Translation5-丁基吡啶甲酸
Merck Number4314
Reaxys-RN125804
Wiswesser Line NotationT6NJ BVQ E4
LabNetwork Molecule IDLN00173993
InChIInChI=1S/C10H13NO2/c1-2-3-4-8-5-6-9(10(12)13)11-7-8/h5-7H,2-4H2,1H3,(H,12,13)
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分类

  • {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, Chemical Structure Class, D to K, Dopamine beta-Hydroxylase, Dopamine beta-hydroxylase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, F, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Pyridines and Pyrimidines, Spectrum of Activity, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学,
  • {SNA} A - K, Antibacterial, Antibiotics A to Z, Antibiotics A-F,

相关文献及参考

  • Wang, H. and Ng, T.B.,, Pharmacological activities of fusaric acid (5-butylpicolinic acid). Life Sci. 65 , 849, (1999) 摘要
  • Baillien, M., et al., Regional distribution and control of tyrosine hydroxylase activity in the quail brain. Brain Res. Bull. 48 , 31-37, (1999) 摘要
  • Bencsics, A., et al., Dopamine, as well as norepinephrine, is a link between noradrenergic nerve terminals and splenocytes. Brain Res. 761 , 236-243, (1997) 摘要
  • Merck 14 ,4314
  • Beil. 22 ,V,2,384

安全信息

RTECSUS5625000
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Hazard Codes Xn
GHS Symbol
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Signal word Warning
Packing GroupIII
Hazard Class6.1(b)
Storage condition -20°C 0-10°C
UN Number 2811
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 29,439,1976

{h

{hazard_c

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 29,439,1976

{hazard_com

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 29,439,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 29,439,1976

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1013 mg/kg
SEX/DURATION            : female 7-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 57,354,1996

其他信息

  • Acros Organics:萎蔫酸 Fusaric acid, 99%(536-69-6)
  • 类别:有毒物质
  • 毒性分级:高毒
  • 可燃性危险特性:可燃, 燃烧时分解有毒氮氧化物气体
  • F:10
  • Sigma Aldrich:536-69-6(sigmaaldrich)
  • 急性毒性:口服- 大鼠 LD50 480 毫克/ 公斤; 口服- 小鼠 LD50: 180 毫克/公斤
  • 储运特性:库房低温, 通风, 干燥; 与食品原料分开存放
  • 灭火剂:水, 二氧化碳, 干粉, 砂土
  • 上游原料:乙醇 --> 盐酸 --> 乙醚 --> 硫酸 --> 二氯甲烷 --> 碳酸钠 --> 三氯甲烷 --> 硫酸镁 --> 氢氧化钾 --> 三乙胺 --> 氯化钠 --> 乙腈 --> 1,4-二氧六环 --> 甲醛 --> 磷酸三钠 --> 盐酸二甲胺 --> 正己醛 --> 1,1-二甲基肼 --> 2-氯丙烯腈
  • MOL 文件:536-69-6.mol
  • TCI Shanghai:5-丁基-2-吡啶甲酸 5-Butylpicolinic Acid,>;98.0%(GC)(T)(536-69-6)
  • 萎蔫酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 F0227 5-丁基吡啶甲酸 5-Butylpyridine-2-carboxylic Acid 5G 6480元 2014/06/02 F0227 5-丁基吡啶甲酸 5-Butylpyridine-2-carboxylic Acid 1G 1930元 2010/06/21 198960010 萎蔫酸 Fusaric acid 99% 1 GR 2259元

系列性分类


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