Nicotinamide 烟酰胺

CAS 98-92-0 MFCD00006395

化学结构图

98-92-0
SMILES: NC(=O)C1CCCNC1

化学属性

Mol. FormulaC6H6N2O
Mol. Weight122.12
Melting Point130°C
Density1.4
Flash Point156.0±20.4°C
TSCAYes
Boiling Point334.4±15.0°C at 760 mmHg
SolubilitySoluble in water (1000 g/l) at 20 °C, ethanol (100 mM), glycerol (1 g/10ml), DMSO (100 mM), methanol, butanol, chloroform, and ether (Slightly).
Appearance 白色针状结晶或结晶性粉末，无臭或稍有臭气，味微苦。相对密度1.4，熔点129-131℃。1g本品可溶于1mL水、1.5mL乙醇或10mL甘油，不溶于乙醚。10%的水溶液的PH为6.5-7.5。在干燥空气中对光、热均稳定，在碱性或酸性溶液中加热则生成烟酸。大白鼠经口LD powder 2.5-3.5g/kg，ADI值不作特殊规定（ECC，1990） 50
Stability对光线敏感

别名和识别编码

Chemical NameNicotinamide
CAS Number98-92-0
Synonym Nicotinamide {LY} Nicotinamide {} {LY} Nicotinamide {} {} {LY} Nicotinamide {} {} {} {LY} Nicotinamide {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY}
PubChem Substance ID936
EC Number202-713-4
Beilstein Registry Number383619
MDL NumberMFCD00006395
Reaxys-RN383619
Merck Number6523
Chemical Name Translation烟酰胺
Wiswesser Line NotationT6NJ CVZ
LabNetwork Molecule IDLN00195184
InChIInChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
Canonical SMILESO=C(C1=CC=CN=C1)N
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分类

  • {SNA} Aloe Vera, Bioactive Small Molecules, Carthamus tinctorius (Safflower oil), Hypericum perforatum (St John's wort), Linum usitatissimum (Flax), N, Nutrition Research, Panax ginseng, Phytochemicals by Plant (Food/Spice/Herb), Vitamin B, Vitamin B3, Vitamins,

产品应用

  • 生化研究，配制组织培养基。

相关文献及参考

  • [2]. Roslan J, et al. Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. Biomed Pharmacother. 2016 Dec 24;86:570-582
  • [3]. Fushima T, et al. Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure. Am J Physiol Renal Physiol. 2016 Dec 7:ajprenal.00501.2016
  • [4]. Suzuki E, et al. Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake. Life Sci. 2010 Apr 24;86(17-18):676-82.
  • [5]. Peck B, et al. SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther. 2010 Apr;9(4):844-55.
  • Al-Nadaf, A., et al.: Bioorg. Medi. Chem., 18, 3088 (2010),
  • Merck 14 ,6523
  • Merck: 14,6523
  • Merck: 14,6523 Beilstein:22,40
  • Sharma, M., et al.: J. Chem. Pharm. Res., 2, 416 (20

安全信息

GHS Symbol
WGK Germany1
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H303 May be harmfully swallowed 吞食可能有害
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSQS3675000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,1390,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2050 mg/kg
TOXIC E

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1680 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 62,19,1946

TYPE OF

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2050 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RAREAE Radiation Research.  (Academic Press, Inc., 1 E. First St., Duluth,
   MN 55802)  V.1-    1954-  Volume(issue)/page/year: 109,479,1987

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 20 mmol/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 69,1353,1982

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   NULSAK Nucleus (Calcutta).  (Dr. A.K. Sharma, Centre of Advanced Studies in
   Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta
   700 019, India)  V.1-    1958-  Volume(issue)/page/year: 28,198,1985

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 126,63,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 mg/plate
REFERENCE :
   TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho.  Annual Report of Tokyo
   Metropolitan Research Laboratory of Public Health.  (Tokyo-toritsu Eisei
   Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
      1949/50-  Volume(issue)/page/year: 37,447,1986

TYPE OF TEST            : Body fluid assay
TEST SYSTEM             : Rodent - rat Ovary
DOSE/DURATION           : 25 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 143,263,1985

其他信息

  • 所属类别二:食品添加剂: 营养强化剂: 维生素类
  • 参考质量标准二:FCC，1997 含量(干燥后) 98.5%～101.0% 重金属(以Pb计，GT-16-2) ≤0.002% 干燥失重(在硅胶上4h) ≤0.5% 熔程 128～131℃ 易炭化物试验 阴性 灼烧残渣(GT-27) ≤0.1%
  • 下游产品:烟酸
  • {Chemical
  • 无臭或几乎无臭，味苦，易溶于水和乙醇，溶于甘油，溶解度: 1000 g/L 水(20°C) ，1g/1.5ml 乙醇， 1g/10ml 甘油。
  • 烟酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 67000934 烟酰胺 25g 15.2元 2011/08/23 SN337601 烟酰胺 100g 204元 2011/04/16 N0078 烟酰胺 Nicotinamide 25G 109元
  • 图谱信息:烟酰胺(98-92-0)质谱(MS) 烟酰胺(98-92-0)核磁图( 13 CNMR) 烟酰胺(98-92-0)红外图谱(IR2) 烟酰胺(98-92-0)红外图谱(IR1) 烟酰胺
  • 上游原料:氢氧化铵 --> 氨 --> 4-氯苯甲醛 --> 烟酸 --> 3-氰基吡啶 --> 3-甲基吡啶
  • 用途四:生化研究；组织培养基的营养成分；临床药物为维生素B族，用于防治糙皮病及口炎、舌炎等病症的治疗。
  • 用途三:与烟酸相同。水溶性较烟酸好，但易与维生素C生成复合物而结块。用量30-80
  • 用途六:生化研究，配制组织培养基。
  • 使用限量:GB 14880—94：同“01017，烟酸”。 以GMP为限(FDA§184.1535，2000)。 日本(1998)：小麦粉35mg/kg；大米7mg/kg；改质奶粉4mg/kg；肉的发色助剂0.02%～0.1%(与维生素C合用)。保持和增强火腿、香肠的色、香、味。不得用于食肉及鲜鱼贝类、鲸肉。
  • 用途二:维生素类药，参与体内代谢过程，用于防治糙皮病等烟酸缺乏症
  • 方法一:将烟酸、硼酸和氨水投入反应锅，搅拌下通入氨气，升温溶解，然后蒸馏回收氨，至120℃后移入脱水锅内继续浓缩，当温度达到145℃后开始加入液氨，并在185-190℃下继续通氨反应20-30h。然后降温至130℃，加蒸馏水稀释，加入活性炭，并在70-80℃通氨脱色2h，反应后趁热过滤，滤液在水中冷析24h，分离结晶，并用乙醇洗涤、干燥得成品，收率89%
  • 所属类别四:饲料添加剂: 维生素添加剂
  • 所属类别三:食品添加剂: 营养强化剂（营养增补剂）: 维生素
  • color:white
  • 方法二:β-甲基吡啶经空气氧化成烟酸，后者与氢氧化铵作用，再加热脱水制得。
  • 方法三:将烟酸、硼酸和氨水投入反应锅，搅拌下通入氨气，升温溶解；然后蒸馏回收氨，至120~C后移入脱水锅内继续浓缩；当温度达145℃后开始加入液氨，并在185～190℃下继续通氨反应20～30h。然后降温至130℃，加蒸馏水稀释，加入活性炭，并在70~80~C下通氨脱色2h；反应后趁热过滤，滤液在水中冷析24h，分离结晶，并用乙醇洗涤、干燥得成品，收率89%。
  • 所属类别一:生物化学品: 生化试剂: 辅酶和维生素
  • 毒性:LD 50 2.5～3.5g/kg(大鼠，经口)。 GRAS(FDA，§182.5535，2000)。 ADI不作特殊规定(EEC，1990)。
  • Nicotinamide is a NAD+ and NADP+ coenzyme precursor. Nicotinamide is an antiinflammatory agent and a PARP-1 enzyme
  • 图
  • 用途五:烟酰胺和烟酸在大多数声合下通用，烟酸在动物体内也生成烟酰胺。体内缺乏烟酸和烟酰胺时，会得糙皮病。因此它们可预防糙皮病。它们在蛋白质和糖的新陈代谢中起作用，可改善人类和动物的营养。除用作医药外，还大量用作食品和饲料添加剂。全世界的生产能力已

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Plant Extracts - Phytochemicals by Chemical Classification
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food & Beverage Standards - Chromatography
  5. Vitamins - Food & Beverage Standards
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Amides - Carbonyl Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. C6 - Pyridines
  1. C6 to C7 - Pyridines
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Vitamins - Nutrition Research
  4. Vitamin B - Vitamins
  5. Vitamin B3 - Vitamin B
  1. C5
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Vitamins
  4. Vitamin B2
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)