Disodium uridine-5'-monophosphate 尿苷酸二钠

CAS 3387-36-8 MFCD00006525

化学结构图

3387-36-8
SMILES: O=c1ccn([C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1.[NaH]

化学属性

Mol. FormulaC9H11N2Na2O9P
Mol. Weight368.14
Density1.865
Melting Point208-210°C
TSCANo
Solubility40 G/100 ML (20 ºC)
Appearance 无色至白色结晶或白色结晶性粉末，稍有特殊滋味。易溶于水(41g／100m1)，微溶于甲醇，不溶于乙醇。
Refractive index-14 ° (C=1, H2O)

别名和识别编码

Chemical NameDisodium uridine-5'-monophosphate
CAS Number3387-36-8
Synonym Uridine 5'-monophosphate (disodium salt) {LY} Uridine 5'-monophosphate (disodium salt) {} {LY} Uridine 5'-monophosphate (disodium salt) {} {} {LY} Uridine 5'-monophosphate (disodium salt) {} {} {} {LY} Uridine 5'-monophosphate (disodium salt) {} {} {} {} {LY} Uridine 5'-monophosphate (disodium salt) {} {} {} {} {} {LY} Uridine 5'-monophosphate (disodium salt) {} {} {} {} {} {} {LY} Uridine 5'-monophosphate (disodium salt) {} {} {} {} {} {} {} {LY} Uridine 5'-monophosphate (disodium salt) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Uridine 5'-monophosphate (disodium salt) {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} Uridine 5'-monophosphate (disodium salt) {} {} {} {} {} {} {} {} {} {} {LY} Uridine 5'-monophosphate (disodium salt) {} {} {} {} {} {} {} {} {} {} {} {LY} Uridine 5'-monophosphate (disodium salt) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Uridine 5'-monophosphate (disodium salt) {} {} {} {} {}
EC Number222-211-9
Beilstein Registry Number3582885
MDL NumberMFCD00006525
PubChem Substance ID169020
Chemical Name Translation尿苷酸二钠
Reaxys-RN3582885
LabNetwork Molecule IDLN00197784
InChIInChI=1S/C9H13N2O9P.2Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18);;/q;2*+1/p-2/t4-,6-,7-,8-;;/m1../s1
Canonical SMILESO[C@@H]([C@H](N(C1=O)C=CC(N1)=O)O2)[C@H](O)[C@H]2COP(O[Na])(O[Na])=O
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分类

  • Nucleotides
  • Carbohydrates & Derivatives
  • Heterocycles
  • Bases & Related Reagents,
  • {SNA} Cell Biology, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, Nucleotide
  • {SNA} Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, Nucleotide
  • {SNA} Nucleotide, 代谢组学, 代谢通路, 代谢通路图中的代谢产物和辅酶分子, 细胞生物学
  • {SNA} Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Nucleotide, 代谢组学, 细胞生物学

产品应用

  • A nucleotide that is a major component of ribonucleic acid. It is found in dietary supplements as well as natural RNA rich foods and has been shown to increase cognitive function in animals.

相关文献及参考

  • Beilstein: 24,IV,1210
  • Wang, L. et al.: J. Mol. Neurosci., 27, 137 (2005);

安全信息

Signal word Warning
GHS Symbol
WGK Germany2
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
RTECSYU7975000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} { 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >12 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 22,618,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3394 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 22,618,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >6 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - dermatitis, irritative (after systemic exposure)
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 22,618,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3698 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  J

Hazard statements

其他信息

  • 尿苷酸二钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 65013531 尿苷-5’-磷酸二钠盐 1g 78元 2011/04/16 U0021 尿苷5'-单磷酸二钠盐水合物 Uridine 5'-Monophosphate Disodium Salt Hydrate 5G 778元 2011/04/16 U0021 尿苷5'-单磷酸二钠盐水合物 Uridine 5'-Monophosphate Disodium Salt Hydrate 25G 2170元
  • 所属类别一:生物化学品: 核酸类: 核苷酸及其衍生物
  • TCI Shanghai:尿苷酸二钠水合物 Uridine 5'-Monophosphate Disodium Salt Hydrate,>;98.0%(LC)(3387-36-8)
  • 所属类别二:食品添加剂: 调味剂（风味增强剂）: 调味剂
  • 水中溶解度:+/- 40% (20°C)
  • 鉴别试验:取试样20mg，溶于0.01mol/L盐酸100ml中。取该溶液10ml，加0.01mol/L盐酸至100ml。该溶液在262nm±2nm处有最大吸收值。 钠盐反应阳性(IT-28)。 取0.03％试样水溶液3ml，加盐酸1ml和溴试液(TS-46)1ml，于水浴上加热30min，吹入空气以排除多余的溴，加10%二羟基甲苯的乙醇液O．2ml及硫酸铁铵盐酸试液(T孓100)3ml，于水浴上加热20min后，应呈绿色。 取(1+20)试样水溶液5ml，加入镁氧试液(TS-133)2ml，应无沉淀。再加硝酸7ml，煮沸10min后用氢氧化钠液(TS-224)中和后，其磷酸盐试验(IT-26)应呈阳性。
  • 含量分析:精确称取试样约500mg，用0.01mol/L盐酸定容至1000ml，取该液10ml，再用0.01mol/L盐酸定容至250ml。用0.01mol/L盐酸液作为对照，在波长260nm处测取吸光度A，液层宽1cm。试样中尿苷酸二钠(C9H11N2Na2O9P)的含量按下式计算：含量(%)=500./式样量(mg)×185.9A/(100-水分(%))×100
  • Acros Organics:尿苷5-单磷酸二钠盐水合物 Uridine 5'-monophosphate, disodium salt, hydrate, 98%(3387-36-8)
  • 用途一:调味剂。加入牛奶中以提高核苷酸量使之接近人乳成分，增强婴幼儿抵抗能力。
  • 方法一:先由酵母中抽提出核酸，再经核酸酶分解和离子交换树脂分离，用氢氧化钠中和后浓缩、结晶而得。
  • MSDS 信息:Disodium uridine-5'-monophosphate(3387-36-8).msds
  • 上游原料:氢氧化钠 --> 核酸 --> 核酸酶
  • F:10-21
  • Sigma Aldrich:3387-36-8(sigmaaldrich)
  • 图谱信息:尿苷酸二钠(3387-36-8)Raman光谱 尿苷酸二钠(3387-36-8)红外图谱(IR2) 尿苷酸二钠(3387-36-8)核磁图( 13 CNMR) 尿苷酸二钠(3387-36-8)红外图谱(IR1)
  • 参考质量标准:日本标准，1999 含量 97%～102% 5%水溶液性状 应无色、基本透明 5%水溶液Ph值 7.0～8.5 砷(以As2O3，GT-3) ≤4mg/kg 其他核酸分解物试验 正常 重金属(Pb计，GT-16) ≤20mg/kg 含水量(GT-32-1) ≤26% 吸光比 正常
  • MOL 文件:3387-36-8.mol
  • 用途二:肝病辅助药。
  • 毒性:LD 50 (大鼠，经口)＞10g/kg；大白鼠经亚急性、慢性、致畸突变和繁殖试验，均无异常发现。
  • Alfa Aesar:尿苷磷酸二钠盐,99% Uridine-5'-monophosphate disodium salt, 99%(3387-36-8)

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleotides - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Synthetic Oligonucleotides and Related Reagents - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Pathways - Metabolomics
  4. Metabolites and Cofactors on the Metabolic Pathways Chart - Metabolic Pathways
  5. Nucleotide - Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Pathways - Metabolomics
  4. Metabolites and Cofactors on the Metabolic Pathways Chart - Metabolic Pathways
  5. Nucleotide - Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. DNA / RNA Synthesis
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  6. Lipid
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Pathways
  6. Metabolites and Cofactors on the Metabolic Pathways Chart
  7. Lipid

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