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• 试剂商城
• 直接询价

分类

• Pharmaceuticals
• {SNA} Building Blocks, Carbonyl Compounds, Chemical Synthesis, Lactones, Organic Building Blocks
• Heterocycles
• Intermediates & Fine Chemicals
• {uni_hamburg} no charge; oxygen heterocycle; alicycle; 6RingOnly; 6ring; ester; lactone; acetal; 1fragment

产品应用

• 通过羟醛冷凝和用三乙基胺甲醛还原得到，苄基取代的米氏酸经由水解、失去CO2和氯磺酸进行Friedel-Crafts 环化生成2，3-二氢-2-茚酮。离子液体中加速醛和米氏酸之间的诺文葛尔浓缩反应（Knoevenagel condensations）。

相关文献及参考

• C-Acylation with acyl chlorides occurs in the presence of 2 equivalents of pyridine in high yield. Alcoholysis of the product provides a good route to ß-keto esters: J. Org. Chem., 43, 2087 (1978); Org. Synth. Coll., 7, 359 (1988), also obtainable by reaction of the Na salt with acid anhydrides in DMF: Synthesis, 451 (1982). Alternatively, mild hydrolysis and decarboxylation of the intermediate acyl Meldrum's acid gives the methyl ketone, providing an alternative to organometallic methods for conversion of acyl chlorides to methyl ketones: Synth. Commun., 10, 221 (1980):
• Knoevenagel condensation with aldehydes gives ylidene derivatives which are solvolyzed by alcohols to give monoesters of alkylidene or arylidene malonic acids: J. Am. Chem. Soc., 74, 5897 (1952). For diastereoselective conde
• Knoevenagel condensation with aldehydes gives ylidene derivatives which are solvolyzed by alcohols to give monoesters of alkylidene or arylidene malonic acids: J. Am. Chem. Soc., 74, 5897 (1952). For diastereoselective condensation with citronellal, followed by intramolecular Diels-Alder reaction, see: Org. Synth. Coll., 8, 353 (1993). With formaldehyde in pyridine gives the stable pyridinium methylide which, on treatment with
• Merck:14,5817
• For phase-transfer alkylation using K2CO3 as base, see: Synthesis, 452 (1982); Bull. Soc. Chim. Belg., 104, 643 (1995). Phase-transfer addition to Michael acceptors also occurs: Synthesis, 224 (1984). Mitsunobu dialkylation with an alcohol and DIAD/Ph3P is also possible: J. Org. Chem., 62, 1617 (1997).
• Nelson, N., et al.: J. Biol. Chem., 245, 143
• Condensation with lactim ethers, catalyzed by Nickel(II)­ 2,4-pentanedionate, 18811, with alcoholysis of the resulting enamino Meldrum's acids, gives of cyclic ß-enamino esters, useful as alkaloid precursors: J. Org. Chem., 43, 4662 (1978); for an example, see: Org. Synth. Coll., 8, 263 (1993).
• Merck:14,5817 Beilstein: 19,V,5,8

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#04102

其他信息

• Sigma Aldrich:2033-24-1(sigmaaldrich)
• 方法一:在搅拌下，将浓硫酸加入丙二酸与乙酐组成的悬浮液中。待大部分丙二酸溶解后，冷却，保持温度为20-25℃，向反应物中加入丙酮，搅匀，冷却过夜，滤出析晶，用冰水洗涤，干燥，得2,2-二甲基-1,3二噁烷-4,6-二酮。
• 图谱信息:丙二酸环(亚)异丙酯(2033-24-1)质谱(MS) 丙二酸环(亚)异丙酯(2033-24-1)核磁图( 13 CNMR) 丙二酸环(亚)异丙酯(2033-24-1)红外图谱(IR1) 丙二酸环(亚)异丙酯(2033-24-1)红外图谱(IR2)
• MSDS 信息:2,2-Dimethyl-1,3-dioxane-4,6-dione(2033-24-1).msds
• 上游原料:丙二酸
• 用途一:用作医药中间体
• Alfa Aesar:丙二酸亚异丙酯,98% Isopropylidene malonate, 98%(2033-24-1)
• TCI Shanghai:米氏酸(丙二酸环亚异丙酯) Meldrum's Acid (=2,2-Dimethyl-1,3-dioxane-4,6-dione),>;98.0%(T)(2033-24-1)
• 下游产品:喹啉-4-硼酸 --> 喹啉-4-羧酸 --> 6-溴-4-氯喹啉 --> 4-溴喹啉 --> 4-氯喹啉 --> 4,7-二甲氧基-1,10-菲咯啉 --> 7-二乙基氨基-3-噻吩甲酰基香豆素 --> 3-(4-硝基苯基)丙酸 --> 6-溴喹啉-4(3H)-酮 --> 3-(2-噻吩)丙酸 --> 3-(4-硝基苯基)-1-丙醇
• 用途二:用于有机合成。
• 丙二酸环(亚)异丙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 M0799 米氏酸(=2,2-二甲基-1,3-二氧六环-4,6-二酮) Meldrum's Acid (=2,2-Dimethyl-1,3-dioxane-4,6-dione) 100G 1180元 2011/04/16 M0799 米氏酸(=2,2-二甲基-1,3-二氧六环-4,6-二酮) Meldrum's Acid (=2,2-Dimethyl-1,3-dioxane-4,6-dione) 25G 400元 2011/04/16 M0799 米氏酸(=2,2-二甲基-1,3-二氧六环-4,6-二酮) Meldrum's Acid (=2,2-Dimethyl-1,3-dioxane-4,6-dione) 500G 4050元
• 存储注意事项:氮气保护
• Acros Organics:2,2-二甲基-1,3-二恶烷-4,6-二酮 2,2-Dimethyl-1,3-dioxane-4,6-dione, 98%(2033-24-1)
• F:10-21
• 水中溶解: 2.5 G/100 ML (20°C)，微溶于乙醇和氯仿。
• 丙二酸环(亚)异丙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0799 米氏酸(=2,2-二甲基-1,3-二氧六环-4,6-二酮) Meldrum's Acid (=2,2-Dimethyl-1,3-dioxane-4,6-dione) 100G 335元 2014/06/02 M0799 米氏酸(=2,2-二甲基-1,3-二氧六环-4,6-二酮) Meldrum's Acid (=2,2-Dimethyl-1,3-dioxane-4,6-dione) 25G 112元 2014/06/02 M0799 米氏酸(=2,2-二甲基-1,3-二氧六环-4,6-二酮) Meldrum's Acid (=2,2-Dimethyl-1,3-dioxane-4,6-dione) 500G 990元
• MOL 文件:2033-24-1.mol