Quinaldine 2-甲基喹啉

CAS 91-63-4 MFCD00006756

化学结构图

91-63-4
SMILES: Cc1ccc2ccccc2n1

化学属性

Mol. FormulaC10H9N
Mol. Weight143.19
Refractive index1.6090 to 1.6130
Density1.058
Boiling Point-
Melting Point-9 - -3
Flash Point79.44°C
TSCAYes
SolubilitySoluble in chloroform, diethyl ether, water (2.5 mg/ml at 20 °C), ether, and alcohol.
Stability对光,空气和湿度敏感

别名和识别编码

Chemical NameQuinaldine
CAS Number91-63-4
Alfabeta NameMETHYLQUINOLINE 2-
MDL Number-
Synonym Quinaldine {LY} Quinaldine {} {LY} Quinaldine {} {} {LY} Quinaldine {} {} {} {LY} Quinaldine {} {} {} {} {LY} Quinaldine {} {} {} {} {} {LY} Quinaldine {} {} {} {} {} {} {LY} Quinaldine {} {} {} {} {} {} {} {LY} Quinaldine {} {} {} {} {} {} {} {} {LY} Quinaldine {} {} {} {} {} {} {} {} {} {LY} Quinaldine {} {} {} {} {} {} {} {} {} {} {LY} Quinaldine {} {} {} {} {} {} {} {} {} {} {} {LY} Quinaldine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Quinaldine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Quinaldine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Quinaldine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Quinaldine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Quinaldine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Quinaldine
EC Number202-085-1
Beilstein Registry Number20,387
Merck Number8047
PubChem Substance ID87575543
Reaxys-RN110309
Chemical Name Translation2-甲基喹啉
Wiswesser Line NotationT66 BNJ C1
LabNetwork Molecule IDLN00173224
InChIInChI=1S/C10H9N/c1-8-6-7-9-4-2-3-5-10(9)11-8/h2-7H,1H3
Canonical SMILESCC1=NC2=CC=CC=C2C=C1
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Q
  • {SNA} Bioactive Small Molecules, Building Blocks, Cell Biology, Chemical Synthesis, Heterocyclic Building Blocks,
  • {SNA} Alphabetical Index of Analytical Standards,
  • {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Q, Quinaldines, 生物活性小分子, 细胞生物学
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules,
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Q, 生物活性小分子, 细胞生物学
  • {SNA} Alph

产品应用

  • A useful ingredient in anti-malaria drugs, in manufacturing dyes, food colorants , pharmaceuticals and pH indicators.

相关文献及参考

  • Short: II/27B
  • Short: II/5
  • Merck: 14,8047 Beilstein:20,387
  • Short: III/35B
  • Merck: 14,8047

安全信息

Warnings 危化品目录(2015) IRRITANT
GHS Symbol
WGK Germany3
Hazard statements
  • H302+H312
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSUZ9625000
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P302+P352+P312+P362+P364
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
Signal word
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
Safety Statements
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Codes Xn
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1230 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1870 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 2 umol/plate
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 36,4630,1988

Restrict 危险品

其他信息

  • 急性毒性:口服-大鼠 LD50: 1230 毫克/公斤
  • Sigma Aldrich:91-63-4(sigmaaldrich)
  • 毒性分级:中毒
  • MSDS 信息:2-甲基喹啉(91-63-4).msds
  • 2-甲基喹啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 Q0005 2-甲基喹啉 2-Methylquinoline 500G 1490元 2014/06/02 Q0005 2-甲基喹啉 2-Methylquinoline 25G 239元 2010/06/21 132172500 2-甲基喹啉 Quinaldine 97% 250 ML 2396元
  • 外观性质:无色有喹啉气味的油状液体,露于空气中易变成红棕色。
  • 可燃性危险特性:受热分解有毒氧化氮气体
  • 类别:有毒物品
  • 用途一:用作染料、医药中间体
  • 灭火剂:二氧化碳、砂土、泡沫、水
  • 用途二:用于制取彩色电影胶片的增碱剂、照相感光剂、橡胶硫化促进剂、润滑油抗氧剂、杀虫剂、杀菌剂以及染料等。
  • MOL 文件:91-63-4.mol
  • Acros Organics:喹哪啶/2-甲基喹啉 Quinaldine, 97%(91-63-4)
  • 方法一:可从煤焦油中提取也可采用合成法制备。萘油馏分和洗油馏分经用硫酸洗涤得到的硫酸喹啉盐基溶液,用蒸气蒸吹除去中性油等杂质,再用碱或氨分解,分离出来的粗喹啉及基同系物经脱水后,用60块理论塔板的高效蒸馏塔精馏,切取基中沸程为237.5-239.5℃的馏分段,可以得到的粗喹啉;继续切取沸程为243-246℃的馏分段,作为提取异喹啉和2-甲基喹啉的原料;继续切取260-267℃的馏分段,作为提取4-甲基喹啉的原料。243-246℃的馏分以盐酸化物形态分离出2-甲基喹啉,将2-甲基喹啉盐酸化物结晶用苯洗涤,再用20%的氢氧化钠溶液将盐分解,精馏切取246.6-247.4℃馏分,可得纯度大于95%的2-甲基喹啉。由苯胺与2,3-二溴丁醛反应可合成得到2-甲基喹啉。
  • 海关编码:29334990
  • 敏感性:Light Sensitive
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 实际上不溶于水,溶于氯仿、乙醚和乙醇。
  • F:8-23
  • 上游原料:丁醛 --> 焦油 --> 异喹啉 --> 发光油 --> 二溴 --> 塔板
  • Alfa Aesar:喹哪啶,97+% Quinaldine, 97+%(91-63-4)
  • 下游产品:异喹啉 --> 喹啉-2-甲醛 --> 盐酸多西环素
  • 图谱信息:2-甲基喹啉(91-63-4)质谱(MS) 2-甲基喹啉(91-63-4)红外图谱(IR1) 2-甲基喹啉(91-63-4)核磁图( 13 CNMR) 2-甲基喹啉(91-63-4)核磁图( 1 HNMR) 2-甲基喹啉(91-63-4)红外图谱(IR2)
  • 刺激数据:皮肤-兔子 10 毫克/24小时 轻度; 眼睛-兔子 0.75 毫克 重度
  • TCI Shanghai:喹哪啶 Quinaldine,>;98.0%(GC)(T)(91-63-4)
  • 2-甲基喹啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 Q0005 2-甲基喹啉 2-Methylquinoline 500G 1220元 2011/04/16 Q0005 2-甲基喹啉 2-Methylquinoline 25G 197元 2010/06/21 132172500 2-甲基喹啉 Quinaldine 97% 250 ML 2396元

系列性分类


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