4-Nitrobenzyl Chloroformate 氯甲酸对硝基苄酯

CAS 4457-32-3 MFCD00007375

化学结构图

4457-32-3
SMILES: O=C(Cl)OCc1ccc([N+](=O)[O-])cc1

化学属性

Mol. FormulaC8H6ClNO4
Mol. Weight215.59
Density1.447
Melting Point32°C
Refractive index1.552-1.556
Flash Point113°C
TSCAYes
Boiling Point330.8°C at 760 mmHg
Appearance 黄色结晶体。
Stability对热和湿度敏感

别名和识别编码

Chemical Name4-Nitrobenzyl Chloroformate
CAS Number4457-32-3
EC Number224-708-6
Beilstein Registry Number912446
MDL NumberMFCD00007375
PubChem Substance ID78205
Synonym 4-Nitrobenzyl carbonochloridate {LY} 4-Nitrobenzyl carbonochloridate {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {} {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {} {} {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {} {} {} {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {} {} {} {} {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzyl carbonochloridate {} {} {} {} {} {} {} {} {} {} {} {} {}
Reaxys-RN912446
Chemical Name Translation氯甲酸对硝基苄酯
LabNetwork Molecule IDLN00223910
InChIKeyMHSGOABISYIYKP-UHFFFAOYSA-N
InChIInChI=1S/C8H6ClNO4/c9-8(11)14-5-6-1-3-7(4-2-6)10(12)13/h1-4H,5H2
Canonical SMILESClC(OCC1=CC=C([N+]([O-])=O)C=C1)=O
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分类

  • {SNA} Active Esters/Additives, Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Synthetic Reagents

相关文献及参考

  • Reagent for protection of amino groups in peptide synthesis. The p-nitrobenzyloxycarbonyl (PNZ) group is more readily cleaved by hydrogenolysis than Cbz, but more resistant to acidic cleavage: J. Am. Chem. Soc., 83, 3066 (1961); J. Chem. Soc., Perkin 1, 2345 (1988). See Appendix 6.
  • Beilstein:6,452
  • Has also been used to protect alcohols as their carbonates which can be cleaved by irradiation or hydrogenolysis: J. Am. Chem. Soc., 100, 313, 8006 (1978).

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S20 When using do not eat or drink 使用时，不得进食，饮水；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S38 In case of insufficient ventilation wear suitable respiratory equipment 通风不良时，佩带适当的呼吸器；
  • S4 Keep away from living quarters 远离生活区；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
Risk Statements
  • R34 Causes burns 会导致灼伤
  • R37 Irritating to respiratory system 刺激呼吸道
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340+P312
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302+H312+H332
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Packing GroupII
UN Number 1759 3261 UN 3261 8/PG 2
Storage condition 2-8°C {LY} 2-8°C Moisture Sensitive {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Hazard Codes 8 C C,T
Hazard Class8

其他信息

  • 下游产品:(R)-1-Boc-3-氨基吡咯烷
  • MOL 文件:4457-32-3.mol
  • Acros Organics:对硝基氯甲酸苄酯 4-Nitrobenzyl chloroformate, 95%(4457-32-3)
  • F:3-4.9
  • Sigma Aldrich:4457-32-3(sigmaaldrich)
  • 敏感性:Moisture Sensitive
  • TCI Shanghai:对硝基苄基氯甲酸酯 4-Nitrobenzyl Chloroformate,>;97.0%(T)(4457-32-3)
  • Alfa Aesar:4-Nitrobenzyl chloroformate, 95%(4457-32-3)
  • Hazard Note:Corrosive/Toxic/Moisture Sensitive
  • MSDS 信息:4-Nitrobenzyl chloroformate(4457-32-3).msds
  • 氯甲酸对硝基苄酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 L1338101 氯甲酸-4-硝基苄酯 5g 221元 2011/04/16 C1077 氯甲酸4-硝基苄酯 4-Nitrobenzyl Chloroformate 25G 1130元 2010/06/21 376040050 氯甲酸对硝基苄酯 4-Nitrobenzyl chloroformate 95% 5 GR 357元

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  4. Active Esters/Additives - Coupling
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Nitro Compounds 硝基化合物
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Protection and Derivatization - Synthetic Reagents
  4. Protecting and Derivatizing Reagents - Protection and Derivatization
  5. Others - Protecting and Derivatizing Reagents
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Peptide Coupling - Peptide Chemistry
  5. Active Esters/Additives - Peptide Coupling

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