2,4-Difluoroaniline 2,4-二氟苯胺

CAS 367-25-9 MFCD00007648

化学结构图

367-25-9
SMILES: Nc1ccc(F)cc1F

化学属性

Mol. FormulaC6H5F2N
Mol. Weight129.11
Boiling Point168.4°C at 760 mmHg
TSCAT
Melting Point-7.5°C
Density1.268 g/mL at 25 °C(lit.)
Refractive index1.5060 to 1.5090
Flash Point62°C
Solubility1-5 G/100 ML AT 20.55 ºC
Appearance 浅黄色油状物。
pH:A

别名和识别编码

Chemical Name2,4-Difluoroaniline
CAS Number367-25-9
Alfabeta NameDIFLUOROANILINE 24-,
MDL NumberMFCD00007648
EC Number206-687-5
Beilstein Registry Number12(1)297
PubChem Substance ID87567998
Merck Number3147
Synonym 2,4-Difluoroaniline {LY} 2,4-Difluoroaniline {} {LY} 2,4-Difluoroaniline {} {} {LY} 2,4-Difluoroaniline {} {} {} {LY} 2,4-Difluoroaniline {} {} {} {} {LY} 2,4-Difluoroaniline {} {} {} {} {} {LY} 2,4-Difluoroaniline {} {} {} {} {} {} {LY} 2,4-Difluoroaniline {} {} {} {} {} {} {} {LY} 2,4-Difluoroaniline {} {} {} {} {} {} {} {} {LY} 2,4-Difluoroaniline {} {} {} {} {} {} {} {} {} {LY} 2,4-Difluoroaniline {} {} {} {} {} {} {} {} {} {} {LY} 2,4-Difluoroaniline {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4-Difluoroaniline {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4-Difluoroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4-Difluoroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4-Difluoroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4-Difluoroaniline {} {} {} {} {} {} {} {} {} {} {}
Reaxys-RN2802556
Chemical Name Translation2,4-二氟苯胺
LabNetwork Molecule IDLN00011028
InChIInChI=1S/C6H5F2N/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2
Canonical SMILESNC1=CC=C(F)C=C1F
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分类

  • {SNA} Amines, Aryl Fluorinated Building Blocks, Building Blocks, C6, Chemical Synthesis, Fluorinated Building Blocks, Nitrogen Compounds, Organic Building Blocks, Organic Fluorinated Building Blocks, Other Fluorinated Organic Building Blocks

安全信息

Warnings IRRITANT, TOXIC
Signal word Danger Warning
GHS Symbol
WGK Germany1
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R33 Danger of cumulative effects 有累积作用的危险
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P332+P313
  • P302+P352+P312+P361+P364
  • P405 Store locked up. 上锁保管。
  • P305+P351+P338+P337+P313
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P302+P350
  • P337+P313
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P403+P235
Hazard statements
  • H331 Toxic if inhaled 吸入中毒
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSBX3680000
Packing GroupIII
UN Number 2941 UN 2941 6.1/PG 3 UN2941
Hazard Codes Xn Xn,T,Xi
Hazard Class6.1
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11(Suppl 12),1,1988

其他信息

  • 用途一:用作合成医药、农药、染料的中间体
  • 下游产品:甲苯磺酸妥舒沙星 --> 替马沙星 --> 吡氟草胺 --> 二氟尼柳 --> 2,4,5-三氟苯甲酸
  • TCI Shanghai:2,4-二氟苯胺 2,4-Difluoroaniline,>;98.0%(GC)(367-25-9)
  • Sigma Aldrich:367-25-9(sigmaaldrich)
  • 2,4-二氟苯胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D1508 2,4-二氟苯胺 2,4-Difluoroaniline 25G 444元 2014/06/02 D1508 2,4-二氟苯胺 2,4-Difluoroaniline 500G 4440元 2010/06/21 114591000 2,4-二氟苯胺 2,4-Difluoroaniline 99% 100 ML 2290元
  • 用途二:2,4-二氟苯胺是有机合成的中间体。医药上用于二氟苯水杨酸和多氟啶酸的合成。氟苯水杨酸是羧酸类非甾抗炎药，国际非专有药名（INN）为Diflunisal。这个水杨酸的新衍生物结构中不含有阿司匹林的乙酰基而含有二氟苯基，所以抗血小板的副作用小，且胃肠道反应轻微，作用时间可维持8-12h，可能是水杨酸类药物中最有发展前途的品种。也是农药的重要中间体。
  • F:8-9-23
  • TSCA:T
  • 图谱信息:2,4-二氟苯胺(367-25-9)核磁图( 1 HNMR) 2,4-二氟苯胺(367-25-9)核磁图( 13 CNMR) 2,4-二氟苯胺(367-25-9)质谱(MS)
  • Acros Organics:2.4-二氟苯胺 2,4-Difluoroaniline, 99%(367-25-9)
  • Hazard Note:Toxic
  • 海关编码:29214210
  • Alfa Aesar:2,4-二氟苯胺,99% 2,4-Difluoroaniline, 99%(367-25-9)
  • 上游原料:铁粉 --> 氟化钾 --> 1,3-二氯苯 --> 间苯二胺 --> 2,4-二氟硝基苯
  • MSDS 信息:1-Amino-2,4-difluorobenzene(367-25-9).msds
  • 方法一:1.2,4-二氟硝基苯还原法将铁粉和氯化铵水溶液加入还原釜中，加热升温至回流后，滴加2,4-二氟硝基苯，加完回流2h，反应完毕，用水蒸气蒸馏，馏出液分离后，用氯化钙干燥，即可得合格产品，收率87%。2.由1,2,4-三氯苯经硝化、氟代及还原脱氯而得；或由间苯二胺经重氮化、置换、硝化、还原而得。
  • MOL 文件:367-25-9.mol

系列性分类

  1. C6 - Amines
  1. C10 - Amines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amines 胺
  6. C11 to C38

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