o-Toluidine 邻甲苯胺

CAS 95-53-4 MFCD00007730

化学结构图

95-53-4
SMILES: Cc1ccccc1N

化学属性

Mol. FormulaC7H9N
Mol. Weight107
Density1.008
Refractive index1.5710 to 1.5740
Autoignition Point899 °F
Vapor Density3.7 (vs air)
Boiling Point89-90
Vapor Pressure0.26 mmHg ( 25 °C)
Melting Point-28
Flash Point86°C(lit.)
TSCAYes
Solubility1.5 G/100 ML (25 ºC)
Stability对光敏感
Appearance liquid
pH:A

别名和识别编码

Chemical Nameo-Toluidine
CAS Number95-53-4
Synonym o-Toluidine 2-Amino-1-methylbenzene 2-methyl-Benzenamine 2-amino-1-methylbenzene 1-Amino-2-methylbenzene; 1-Methyl-2-aminobenzene; 2-Aminotoluene; 2-Methylaniline 2-Aminotoluene, 2-Methylaniline 2-Methylbenzenamine 2-aminotoluene 鄰甲苯胺 039-01 [6] o-Aminotolue O-toluidine 2-Aminotoluene 2-甲基苯胺 2-氨基甲苯,2-甲基苯胺,邻氨基甲苯 benzenamine, 2-methyl- o-Aminotoluol (2-methylphenyl)amine 2-methylphenylamine ORTHO-TOLUIDINE O-TOLUIDINE REAGENT o-Aminotoluene aniline,2-methyl- 2-Toluidine 2-methylbenzamine 邻甲苯胺/2-甲基苯胺 2-methylaniline AKOS BBS-00004267
MDL NumberMFCD00007730
EC Number202-429-0
Beilstein Registry Number741981
PubChem Substance ID7242
Merck Number9536
Reaxys-RN741981
Chemical Name Translation邻甲苯胺
Wiswesser Line NotationZR B1
LabNetwork Molecule IDLN00194951
InChIInChI=1S/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H3
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分类

  • {SNA} 2002/61/E
  • Mutagenesis Research Chemicals
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {SNA} Analytical Reagents, Analytical/Chromatography, Derivatization Reagents, Derivatization Reagents TLC, TLC Reagents, S-Z, TLC Visualization Reagents (alphabet
  • {SNA} Amines, Building Blocks, C6, Chemical Synthesis, Nitrogen Compounds,

产品应用

  • 测定铈、镧、钕、镨、钍和锆时的沉淀剂, 检定氰化氢、铱、镍、锇、钯、铂、钒、铬、金、银、游离氯和双氧水, 测定矿物折射率的浸渍液、有机合成。

相关文献及参考

  • Beilstein:12,772
  • Short: II/27B
  • Short: II/5
  • ########
  • Short: III/20a

安全信息

Signal word
GHS Symbol
WGK Germany3
Safety Statements
Risk Statements
  • R45 May cause cancer 可能致癌
  • R36 Irritating to eyes 刺激眼睛
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353
  • P308+P313
  • P304+P340+P310
  • P305+P351+P338
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P337+P313
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P332+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P370+P378
  • P301+P312+P330
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P310
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P403+P233
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H350 May cause cancer 可能致癌
  • H302 Harmful if swallowed 吞食有害
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H301+H331
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H331 Toxic if inhaled 吸入中毒
  • H301 Toxic if swallowed 吞食有毒
  • H227 Combustible liquid 可燃液体
RTECSXU2975000
Packing GroupII
UN Number
Storage condition 密封阴凉避光保存。 Air & Light Sensitive 2-8°C
Hazard Codes T,N T,N,F
Hazard Class6.1
Warnings 危化品目录(2015) 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 840 mg/kg/14W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,155,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
                          female 15-21 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 78,1402,1974

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7250 mg/kg/23W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   APMIAL Acta Pathologica et Microbiologica Scandinavica.  (Copenhagen,
   Denmark)  V.1-77, 1924-69.  For publisher information, see ACPADQ.
   Volume(issue)/page/year: 26,447,1949

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 109 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Blood - tumors
REF

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - pigmented or nucleated red blood cells
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,155,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 840 mg/kg
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - pigmented or nucleated red blood cells
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,155,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - dyspnea
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   XPHBAO U.S. Public Health Service, Public Health Bulletin.  (Washington, DC)
    Volume(issue)/page/year: 271,49,1941

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 125 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   5,451,1985

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   5,587,1985

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/

T

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 40 ug/plate
REFERENCE :
   PJABDW Proceedings of the Japan Academy, Series B: Physical and Biological
   Sciences.  (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31,
   Japan)  V.53-    1977-  Volume(issue)/page/year: 53,34,1977

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 5,355,1982

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 2500 umol/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   5,469,1985

{hazard_c

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 9520 mg/kg
SEX/DURATION            : female 17 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - physical
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 27(9),47,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 9520 mg/kg
SEX/DURATION            : male 17 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Effects on Newborn - physical
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 27(9),47,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 952 mg/kg
SEX/DURATION            : female 17 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and

Restrict 危险品

其他信息

  • MSDS 信息:2-甲基苯胺(95-53-4).msds
  • 外观性质:无色或淡黄色油状液体。
  • 图谱信息:邻甲基苯胺(95-53-4)核磁图( 13 CNMR) 邻甲基苯胺(95-53-4)质谱(MS) 邻甲基苯胺(95-53-4)红外图谱(IR2) 邻甲基苯胺(95-
  • 蒸气密度:3.7 (vs air)
  • 毒性分级:中毒
  • 甲苯胺异构体:甲苯胺有3种异构体，即邻甲基苯胺、间甲基苯胺和对甲基苯胺，邻甲苯胺为原位取代产物，间甲苯胺为移位取代产物。 邻甲苯胺又称“邻氨基甲苯”，为无色至浅黄色液体，曝露在空气中及光照下变为红棕色，遇甲醛生成白色沉淀。微溶于水，溶于稀酸、醇、醚中。相对密度：1.004(20℃)；熔点：-16.3℃ (β型)，-24.4℃(α型)；沸点：199.7℃; 闪点：85℃；自燃点：482.2℃；蒸汽密度：3.69。其蒸汽与空气可形成爆炸性混合物，在空气中的最高容许浓度为5ppm。遇明火能燃烧，受高热会散发有毒气体，毒性与苯胺相似，进入体内容易形成高铁血红蛋白，而发生神经性障碍及发绀。 邻甲苯胺是生产染料及颜料的重要中间体，可用于制备直接红62，红色基RL、大红色基G、枣红色基GBC、碱性品红、色酚AS-D、酸性红35、158、265，溶剂红124，偶氮染料的重氮组分及偶合组分，制有机颜料黄14、17、蓝19；农药原料，生产农药杀菌剂“三环唑”，杀虫剂螟蛉畏、杀虫脒；除草剂乙草胺；橡胶硫化促进剂的原料；糖精原料；缓蚀剂原料等。在
  • 危险情况:(1) 邻甲苯胺有毒，吸入蒸气，或经皮肤吸收或摄入均会引起中毒。是已知致癌物。 (2) 易燃，燃点482℃，蒸气能与空气形成爆炸性混合物。空气中的容许浓度美国为2ppm (9mg/m3)。
  • 测定方法:在空气中的测定：用硅石吸附，正丙醇处理，气相色谱法分析。
  • {Chemica
  • 露置空气中或见光逐渐变成浅红棕色, 能随水蒸气挥发。能溶于醇、醚和稀酸，微溶于水。低毒，半数致死量(大鼠，经口)670mg/kg。有致癌可能性。有刺激性。
  • Sigma Aldrich:95-53-4(sigmaaldrich)
  • 灭火剂:雾状水, 泡沫
  • 贮存:用玻璃瓶或金属桶盛装，防止机械性损坏。放在阴凉、干燥、通风良好的地方。最好使用露天或附建的仓库，严禁烟火，远离容易起火地点，避光、密封保存。与氧化剂隔开。
  • 存储注意事项:氮气保护;空气敏感
  • 爆炸物危险特性:与空气混合可爆
  • 下游产品:8-甲基喹啉 --> 2-甲基-6-乙基苯胺 --> 3-碘吲唑 --> 硫化黄GC --> 硫化褐 10号 --> 3-溴吲唑 --> 硫化蓝7 --> 2-溴甲苯 --> 冰染偶合组分 18 --> N-甲基-邻甲基苯胺 --> 盐基品红 --> 4-氯-2-甲基苯胺 --> 氯唑西林钠 --> 叔戊酰邻甲基苯胺 --> 弱酸性亮红10b --> 2'-甲基乙酰乙酰苯胺 --> 2-甲基乙酰苯胺 --> 3-硝基吲唑 --> 碱性品红 --> 盐酸溴己新 --> 溴苄乙胺 --> 冰染重氮组分 34 --> N-邻甲苯基硫脲 --> 1-(2-甲基苯基)哌嗪 --> 仲戊醇 --> 2,4-二溴-6-甲基苯胺 --> 杀虫脒 --> 溴甲酚紫 --> 1-(2-甲基苯基)哌嗪盐酸盐 --> N,N-二乙基-邻甲基苯
  • 常规方法:采用铁桶包装。贮存于阴凉、通风的仓库内，严禁烟火。按有毒化学品规定贮运。
  • 下游产品:8-甲基喹啉 --> 2-甲基-6-
  • 用途一:用作分析试剂和染料中间体，也用于有机合成
  • 类别:有毒物品
  • 制备方法:1，在稀酸介质中，用邻硝基甲苯与铁粉
  • 用途二:用作染料、农药、医药及有机合成中间体
  • 急救:此化学品如进入眼中，立即用水或洗眼剂冲洗; 如接触皮肤，立即用肥皂和水洗净; 如有人大量吸入，立即移离现场
  • color:light yellow to light amber
  • 用

系列性分类

  1. Life Science 生命科学
  2. Hematology and Histology 血液学和组织学
  3. Stains and Dyes - Hematology and Histology
  4. Natural Dyes - Stains and Dyes
  1. C8 - Amines
  1. C6 - Amines
  1. C10 to C11 - Amines
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Volatiles/ Semivolatiles - Environmental Standards
  6. Alpha Sort - Volatiles/ Semivolatiles
  7. T-Z - Alpha Sort
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Volatiles/ Semivolatiles - Environmental Standards
  6. Alpha Sort - Volatiles/ Semivolatiles
  7. T-Z - Alpha Sort
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Method Specific - Analytical Standards
  4. European Community: ISO, DIN and DL 152 - Method Specific
  5. 2002/61/EC - European Community: ISO, DIN and DL 152
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Derivatization Reagents 衍生分析试剂
  4. Derivatization Reagents TLC - Derivatization Reagents
  5. TLC Visualization Reagents (alphabetic sort) - Derivatization Reagents TLC
  6. TLC Reagents, S-Z - TLC Visualization Reagents (alphabetic sort)
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. T - Alphabetic
  5. TF - TO - T
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amines 胺
  6. C2 to C6
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. TLC Visualization Reagents (alphabetic sort)
  4. TLC Reagents, N-R
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. Derivatization Reagents TLC
  4. TLC Visualization Reagents (alphabetic sort)
  5. TLC Reagents, N-R
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals and Reagents
  4. Stains and Dyes
  5. Natural Dyes