2,4-Dimethylaniline 2,4-二甲基苯胺

CAS 95-68-1 MFCD00007738

化学结构图

95-68-1
SMILES: Cc1ccc(N)c(C)c1

化学属性

Mol. FormulaC8H11N
Mol. Weight121.18
Refractive index1.5570 to 1.5610
Boiling Point218
Density0.98
Melting Point-14
Flash Point90.56°C
TSCAYes
Autoignition Point860 °F
Vapor Density4.2 (vs air)
Vapor Pressure0.16 mmHg ( 25 °C)
Solubility5 G/L (20 ºC)
Stability对光敏感
pH:A

别名和识别编码

Chemical Name2,4-Dimethylaniline
Synonym 2,4-Dimethylaniline {LY} 2,4-Dimethylaniline 2,4-Dimethylbenzenamine 2,4-Dimethylbenzeneamine 2,4-Xylylamine 2,4-dimethyl-anilin 2,4-dimethyl-aniline 2,4-二甲代苯胺 2,4-二甲基苯胺 2,4-二甲苯 2-Methyl-p-toluidine 4-Amino-1,3-dimethylbenzene m-Xylidine AKOS BBS-00003656 LABOTEST-BB LTBB000473 asym. m-Xylidin m-Xylidine, 1-Amino-2,4-dimethylbenzene, 2,4-Xylidine, 4-Amino-m-xylene m-Xylidine, 1-​Amino-​2,4-​dimethylbenzene, 2,4-Xylidine, 4-Amino-m-xylene {} {LY} 2,4-Dimethylaniline {} {} {LY} 2,4-Dimethylaniline {} {} {} {LY} 2,4-Dimethylaniline {} {} {} {} {LY} 2,4-Dimethylaniline {} {} {} {} {} { {} {} {} {} {} {LY} 2,4-Dimethylaniline {} {} {} {} {} {} {LY} 2,4-Dimethylaniline {} {} {} {} {} {} {} {LY} 2,4-Dimethylaniline {} {} {} {} {
CAS Number95-68-1
PubChem Substance ID87567308
EC Number202-440-0
Beilstein Registry Number636243
MDL NumberMFCD00007738
Reaxys-RN636243
Merck Number10084
Chemical Name Translation2,4-二甲基苯胺
Wiswesser Line NotationZR B1 D1
LabNetwork Molecule IDLN00221171
InChIInChI=1S/C8H11N/c1-6-3-4-8(9)7(2)5-6/h3-5H,9H2,1-2H3
Canonical SMILESNC1=CC=C(C)C=C1C
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分类

  • {Chemicalbook} 农药中间体: 杀螨剂中间体
  • Alpha Sort, Alphabetic, Amines, Analytical Standards, Analytical/Chromatography, Aromatics, Chemical Class, Chromatography, D, DID - DIN, Environmental Standards, Volatiles/ Semivolatiles
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {SNA} Amines, Building Blocks, C8, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks

产品应用

  • 偶氮染料的重要中间体,可制备乳胶成色剂,亦可用于有机合成及药物的制造。

相关文献及参考

  • Short: III/35D2
  • Beilstein:12,1111

安全信息

GHS Symbol
WGK Germany3
Hazard Codes 6.1 T,N
Hazard statements
  • H227 Combustible liquid 可燃液体
  • H301 Toxic if swallowed 吞食有毒
  • H301+H311+H331
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H331 Toxic if inhaled 吸入中毒
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSZE8925000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P312+P330
  • P302+P352+P312
  • P304+P340+P312
  • P305+P351+P338+P337+P313
  • P308+P311
  • P308+P313
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P337+P313
  • P370+P378
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 1711 UN 1711 6.1/PG 2
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R33 Danger of cumulative effects 有累积作用的危险
  • R51/53
Safety Statements
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Packing GroupII
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Class6.1
Warnings 危化品目录(2015)
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 149 ppm/7H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
   Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
   Industrial Hygienists, Inc., 1986  Volume(issue)/page/year: 6,1743,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB214-270

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 467 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB214-270

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 206,183,1988

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 umol/plate
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 34,157,1986

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 394,53,1997

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 46,305,1977

Restrict 危险品

其他信息

  • Acros Organics:2,4-二甲基苯胺 2,4-Dimethylaniline, 99%(95-68-1)
  • TCI Shanghai:2,4-二甲基苯胺 2,4-Dimethylaniline,>;98.0%(GC)(T)(95-68-1)
  • 上游原料:间二甲苯 --> 1,3-二甲基-4-硝基苯 --> 2,6-二甲基硝基苯
  • F:8
  • 下游产品:2,6-二甲基苯胺 --> 双甲眯 --> N-(2,4-二甲苯基)-N'-甲基甲脒盐酸盐 --> 6-氨基-2-(2,4-二甲苯基)-1H-苯并[DE]异喹啉-1,3(2H)-二酮 --> 溶剂黄 18
  • 类别:有毒物品
  • 图谱信息:2,4-二甲基苯胺(95-68-1)质谱(MS) 2,4-二甲基苯胺(95-68-1)红外图谱(IR1) 2,4-二甲基苯胺(95-68-1)核磁图( 13 CNMR) 2,4-二甲基苯胺(95-68-1)核磁图( 1 HNMR)
  • 用途二:2,4-二甲基苯胺是合成杀虫杀螨剂单甲脒、双甲脒的中间体,还可用于制造偶氮染料等。
  • Sigma Aldrich:95-68-1(sigmaaldrich)
  • 用途一:用作农药、医药和染料的中间体
  • 蒸气密度:4.2 (vs air)
  • 2,4-二甲基苯胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010331 2,4-二甲基苯胺 100ml 125元 2011/08/23 A30149301 2,4-二甲基苯胺 250ml 509元 2011/08/23 K3948001 2,4-二甲基苯胺 100ml 175元
  • 外观性质:无色油状液体。
  • 用途三:偶氮染料的重要中间体,可制备乳胶成色剂,亦可用于有机合成及药物的制造。
  • MSDS 信息:2,4-二甲基苯胺(95-68-1).msds
  • Alfa Aesar:2,4-二甲基苯胺,99% 2,4-Dimethylaniline, 99%(95-68-1)
  • MOL 文件:95-68-1.mol
  • 急性毒性:口服- 大鼠 LD50: 467 毫克/ 公斤; 口服- 小鼠 LD50: 250 毫克/ 公斤
  • 储运特性:库房通风低温干燥; 与酸类、氧化剂、食品添加剂分开存放
  • 防护措施:高毒。通过吞咽、吸入蒸气或经皮肤吸收而引起中毒,其中毒类似于苯胺的血液中毒,生成高铁血红蛋白,造成对组织供氧不足。家兔经口LD50为620mg/kg,空气中最高容许浓度5mg/m3。防护方法参照“苯胺”。
  • 常规方法:采用铁桶密封包装,贮存于阴凉、通风处。
  • 毒性分级:高毒
  • 在光和空气中会变深,能与空气一同挥发,微溶于水,溶于乙醇,乙醚,苯及酸溶液。水中溶解度:5 g/l (20°C)。
  • 海关编码:29214910
  • 可燃性危险特性:明火可燃; 与氧化剂起作用;高热分解有毒氮氧化物烟雾
  • 蒸气压:0.16 mm Hg ( 25 °C)
  • 方法一:2,4-二甲基苯胺是由间二甲苯经硝化,得2,4-二甲基硝基苯和2,6-二甲基硝基苯,精馏后2,4-二甲基硝基苯进行催化加氢还原而得产品。
  • 灭火剂:泡沫、二氧化碳、干粉、砂土

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