2,4,6-Trimethylaniline 2,4,6-三甲基苯胺

CAS 88-05-1 MFCD00007740

化学结构图

88-05-1
SMILES: Cc1cc(C)c(N)c(C)c1

化学属性

Mol. FormulaC9H13N
Mol. Weight135.21
Refractive index1.5490 to 1.5530
Boiling Point231.3°C at 760 mmHg
Density0.963
Flash Point96.11°C
TSCAYes
Melting Point-5°C
SolubilitySoluble in carbon tetrachloride (slightly). Insoluble in water.
Stability对空气和光敏感
Appearance liquid (clear) 浅黄色油状物。

别名和识别编码

Chemical Name2-Amino-1,3,5-Trimethylbenzene
MDL NumberMFCD00007740
CAS Number88-05-1
Synonym 2,4,6-Trimethylaniline {LY} 2,4,6-Trimethylaniline {} {LY} 2,4,6-Trimethylaniline {} {} {LY} 2,4,6-Trimethylaniline {} {} {} {LY} 2,4,6-Trimethylaniline {} {} {} {} {LY} 2,4,6-Trimethylaniline {} {} {} {} {} {LY} 2,4,6-Trimethylaniline {} {} {} {} {} {} {LY} 2,4,6-Trimethylaniline {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylaniline {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylaniline {} {} {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylaniline {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylaniline {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylaniline {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4,6-Trim
PubChem Substance ID6913
EC Number201-794-3
Beilstein Registry Number636559
Chemical Name Translation2,4,6-三甲基苯胺
Reaxys-RN636559
Wiswesser Line NotationZR B1 D1 F1
LabNetwork Molecule IDLN00227047
InChIInChI=1S/C9H13N/c1-6-4-7(2)9(10)8(3)5-6/h4-5H,10H2,1-3H3
Canonical SMILESCC1=CC(C)=C(N)C(C)=C1
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分类

  • {SNA} Amines, Building Blocks, C9, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment

产品应用

  • 弱酸性染料普拉兰RAW的中间体。

相关文献及参考

  • Short: III/35D2
  • Beilstein:12,1160
  • Short: III/35B

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H330 Fatal if inhaled 吸入致命
  • H302+H312
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSBZ0700000
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P308+P313
  • P332+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P301+P312+P330
  • P302+P350
  • P337+P313
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
Signal word
Packing GroupII
UN Number UN2810
Risk Statements
  • R26 Very toxic by inhalation 吸入极毒
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R23 Toxic by inhalation 吸入有毒
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R33 Danger of cumulative effects 有累积作用的危险
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Hazard Codes T+ T+,T
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY
Hazard Class6.1
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4200 mg/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   AICCA6 Acta Unio Internationalis Contra Cancrum.  (Louvain, Belgium) V.1-20,
   1936-64.  For publisher information, see IJCNAW. Volume(issue)/page/year:
   20,1364,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4000 mg/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Endocrine - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   58,377,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 506 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   HYSAAV Hygiene and Sanitation (USSR).  English translation of GISAAA.
   (Springfield, VA)  1964-71. Discontinued.  Volume(issue)/page/year:
   34(1-3),13,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 590 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Pro

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 743 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,464,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 372 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   HYSAAV Hygiene and Sanitation (USSR).  English translation of GISAAA.
   (Springfield, VA)  1964-71. Discontinued.  Volume(issue)/page/year:
   34(1-3),13,1969

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - rat Fibroblast
DOSE/DURATION           : 74 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 211,279,1988

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 394,53,1997

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 3 mmol/L/4H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 77,317,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ug/plate
REFERENCE :
   54DEAI "Occupati

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   54DEAI "Occupational Health in the Chemical Industry, Proceedings of the
   International Congress, 11th, Alberta, Canada, 1983," Oxford, R.R., et al.,
   eds., Calgary, Alberta, Canada, Univ. of Calgary, 1984
   Volume(issue)/page/year: -,497,1984

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 4 mmol/L/48H (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 211,279,1988

{hazard_

其他信息

  • TCI Shanghai:2,4,6-三甲基苯胺 2,4,6-Trimethylaniline,>;99.0%(GC)(88-05-1)
  • 方法一:将硫酸、硝酸配成混酸,与均三甲苯在10℃以下常压硝化4h,静置分层,放掉废酸。将得到的2,4,6-三甲基硝基苯、铁粉、盐酸和水按1:3.74:0.9:2.22(mol比)配料在100-105℃还原反应8h。然后从还原物蒸馏出粗均三甲苯胺,再用蒸馏提纯。
  • MOL 文件:88-05-1.mol
  • 海关编码:29214980
  • 用途一:主要用于合成染料,是弱酸艳蓝RAW的中间体
  • color:clear brown
  • Acros Organics:2,4,6-三甲基苯胺 2,4,6-Trimethylaniline, 97%(88-05-1)
  • Sigma Aldrich:88-05-1(sigmaaldrich)
  • 均三甲苯胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T0467 2,4,6-三甲基苯胺 2,4,6-Trimethylaniline 500ML 1310元 2014/06/02 T0467 2,4,6-三甲基苯胺 2,4,6-Trimethylaniline 25ML 199元 2010/06/21 157965000 均三甲苯胺 2,4,6-Trimethylaniline 97% 500 GR 1720元
  • 上游原料:均三甲苯 --> 甲基硝基苯
  • 用途二:弱酸性染料普拉兰RAW的中间体。
  • 不溶于水,微溶于四氯化碳,易溶于丙酮等大多数有机溶剂,遇光易氧化,使颜色变深。
  • 图谱信息:均三甲苯胺(88-05-1)核磁图( 13 CNMR) 均三甲苯胺(88-05-1)质谱(MS) 均三甲苯胺(88-05-1)红外图谱(IR1) 均三甲苯胺(88-05-1)核磁图( 1 HNMR) 均三甲苯胺(88-05-1)红外图谱(IR2)
  • Alfa Aesar:2,4,6-三甲基苯胺,98% 2,4,6-Trimethylaniline, 98%(88-05-1)
  • 下游产品:酸性蓝80 --> 弱酸嫩黄G --> 苯酮唑 --> 酸性兰 129 --> 溶剂蓝 104
  • MSDS 信息:2,4,6-Trimethylbenzenamine(88-05-1).msds

系列性分类