3-Aminophenol 3-氨基苯酚

CAS 591-27-5 MFCD00007786

化学结构图

591-27-5
SMILES: NC1CCCC(O)C1

化学属性

Mol. FormulaC6H7NO
Mol. Weight109
Boiling Point164
Melting Point120-124
Density1.21
Flash Point178°(352°F)
TSCAYes
Solubility微溶于水,溶于醇、醚。
Stability对光敏感
pH:A

别名和识别编码

Chemical Name3-Aminophenol
CAS Number591-27-5
PubChem Substance ID11568
EC Number209-711-2
Beilstein Registry Number636059
MDL NumberMFCD00007786
Reaxys-RN636059
Merck Number460
Synonym m-Hydroxyaniline {LY} m-Hydroxyaniline phenol, 3-amino- {} {LY} m-Hydroxyaniline {} {} {LY} m-Hydroxyaniline {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {} {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {} {} {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {} {} {} {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {} {} {} {} {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {} {} {} {} {} {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} m-Hydroxyaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Chemical Name Translation3-氨基苯酚
Wiswesser Line NotationZR CQ
LabNetwork Molecule IDLN00198706
InChIInChI=1S/C6H7NO/c7-5-2-1-3-6(8)4-5/h1-4,8H,7H2
Canonical SMILESOC1=CC=CC(N)=C1
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分类

  • {SNA} Building Blocks, C6 to C8,
  • {SNA} A, A-B, AM to AQ, All alphabetically sorted, Alphabetical Index of Analytical Standards, Amines, Analytical Standards,
  • A, A-B, AM to AQ, Alpha sort, Alphabetic, Amines, Analytical Standards, Analytical/Chromatography, Aromatics, Chemical Class, Chromatography, Environmental Standards, Pesticides & Metabolites
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards
  • {SNA} A-B,
  • {SNA} Additional Standards,
  • {SNA} Building Blocks,

产品应用

  • 有机合成。染料和对氨基水杨酸的中间体。

相关文献及参考

  • Short: II/27B
  • Merck:14,460
  • Merck:14,460 Beilstein:13(3)931
  • Short: II/3

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
  • H302+H332
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes 6.1 Xn;N
RTECSSJ4900000
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P302+P350
  • P304+
  • P304+P340
  • P305+P351+P338
  • P332+P313
  • P337+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Safety Statements
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Risk Statements
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R51/53
UN Number 2512
Packing GroupIII
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Class6.1
Warnings 危化品目录(2015)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 50(3),4,1985

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 131,151,1961

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1162 mg/m3
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - excitement
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 32(1),49,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 924 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - excitement
   Lungs, Thorax, or Respiration - other ch

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 190 umol/L
REFERENCE :
   CRTOEC Chemical Research in Toxicology.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC
   20037)  V.1-    1988-  Volume(issue)/page/year: 4,151,1991

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Neurospora crassa
DOSE/DURATION           : 220 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 167,35,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 3333 ug/plate
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11(Suppl 12),1,1988

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 28300 ug/m3/24H
REFERENCE :
   BZARAZ Biologicheskii Zhurnal Armenii.  Biological Journal of Armenia. (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.19-    1966-
   Volume(issue)/page/year: 40,62,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1245 mg/kg
SEX/DURATION            : female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 48(9),19,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1245 mg/kg
SEX/DURATION            : female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 48(9),19,1983

Restrict 危险品

其他信息

  • 图谱信息:3-氨基苯酚(591-27-5)核磁图( 13 CNMR) 3-氨基苯酚(591-27-5)核磁图( 1 HNMR) 3-氨基苯
  • 灭火剂:二氧化碳、砂土、泡沫、雾状水、干粉
  • MOL 文件:591-27-5.mol
  • 防护措施:氨基苯酚分子内存在两个有毒基团,所以具有苯胺和苯酚双重毒性。可经皮肤吸收并引起皮炎,能引起高铁血红蛋白症和哮喘。小鼠经口LD50为4.5mg/kg。
  • 刺激数据:皮肤-兔子 12.5 毫克/24小时 轻度; 眼睛-兔子 100 毫克/24 小时 中度
  • 方法二:以间氨基苯磺酸为原料,经碱熔、酸化而得。将间氨基苯磺酸用水搅拌成浆状,加热至60℃,滴加烧碱溶液,使pH为7-8,过滤得间氨基苯磺酸钠盐溶液。在碱熔锅内投入固碱或液碱,加热熔化或蒸浓,在275℃逐步加入间氨基苯磺酸钠盐溶液。加毕,继续保持275℃反应75min。将物料稀释于亚硫酸钠洗液中,过滤分离亚硫酸钠。分离亚硫酸钠后的间氨基苯酚钠溶液在50℃以下加入31%盐酸至中性。降温到35℃,析出粗间氨基酚,过滤,将滤饼加入蒸馏锅,真空蒸馏,馏出的精制间氨基苯酚经制
  • 可燃性危险特性:明火可燃; 受热分解有毒氮氧化物和氯化物气体
  • 用途三:用于有机合成
  • 下游产品:间苯二酚 --> C545T --> 4-氨基水杨酸 --> 赤藓红B --> 罗丹明 123 --> 7-羟基喹啉 --> 间溴苯酚 --> 香豆素 314T --> 7-氨基-4-甲基香豆素 --> 尼多克罗 --> 间氨基苯乙醚 --> 3-[(甲氧羰基)氨基]苯基-N-(3-甲基苯基)氨基甲酸酯 --> 9-醛基-8-羟基-1,1,7,7-四甲基久洛尼定 --> 罗丹明 --> 灭锈胺 --> 直接黑168 --> 香豆素 151 --> 3-氨基苯异丙醚 --> 荧光增白剂SWN --> 3-羟基-N,N-二甲基苯胺 --> 对氨基水杨酸钠
  • 类别:有毒物品
  • 海关编码:29222900
  • 用途四:间氨基苯酚是杀菌剂灭锈胺、氟酰胺的中间体。
  • 方法一:其制备方法是将间氨基苯磺酸用水搅拌成浆状,加热至60℃,滴加烧碱溶液(pH=7~8),过滤得间氨基苯磺酸盐,将该盐溶液慢慢加到浓烧碱水溶液中,于270℃反应至Na 2 SO 3 不再生成为止,加水稀释过滤,分去Na 2 SO 3 残渣,然后过热水稀释碱溶液,稀释温度保持在100~110℃进行热过滤,滤液用30%工业盐酸酸化,温度不高于90℃,酸化终点pH=7~8,酸化后降温至20℃以下,静置,结晶,过滤,再经真空蒸馏即得成品。
  • Alfa Aesar:3-氨基苯酚,98+% 3-Aminophenol, 98+%(591-27-5)
  • 3-氨基苯酚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80005324 3-氨基酚;间氨基酚;3-羟基苯胺;3-氨基-1-羟基苯 25g 25.7元 2011/04/16 A0383 3-氨基苯酚 3-Aminophenol 25G 187元 2011/04/16 A0383 3-氨基苯酚 3-Aminophenol 500G 862元
  • 用途二:用作染料及医药中间体,用于制造偶氮染料
  • 职业标准:STEL 1 毫克/立方米
  • 色指数:76545
  • TCI Shanghai:3-氨基苯酚 3-Aminophenol,>;98.5%(T)(591-27-5)
  • 用途六:有机合成。染料和对氨基水杨酸的中间体。
  • 用途五:染料中间体,用于制造偶氮染料,也可用于毛皮染料,如毛皮棕EG、毛皮黄EG等。医药中间体,用于生产抗结核药对氨基水杨酸。也用于生产抗氧剂、稳定剂、显影剂和彩色胶片,还用于头发染色等。
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • MSDS 信息:3-氨基苯酚(591-27-5).msds
  • {Chemicalbook
  • 见光易变色。水中溶解度: 3

系列性分类