4,4'-Sulfonyldianiline 4,4’-二氨基二苯砜

CAS 80-08-0 MFCD00007887

化学结构图

80-08-0
SMILES: NC1C=CC(=CC=1)S(=O)(=O)C1C=CC(N)=CC=1

化学属性

Mol. FormulaC12H12N2O2S
Mol. Weight248.30
Density1.361
Melting Point173-178°C
TSCAT
Solubility<0.1 G/100 ML AT 20 ºC
Stability对湿度敏感
Boiling Point511.7°C at 760 mmHg

别名和识别编码

Chemical Name4,4'-Sulfonyldianiline
CAS Number80-08-0
Alfabeta NameAMINOPHENYLSULFONYLANILINE 44[]()--
MDL NumberMFCD00007887
Synonym Dapsone {LY} Dapsone {} {LY} Dapsone {} {} {LY} Dapsone {} {} {} {LY} Dapsone {} {} {} {} {LY} Dapsone {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dapsone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
EC Number201-248-4
Beilstein Registry Number788055
PubChem Substance ID87566830
Reaxys-RN788055
Merck Number2822
Chemical Name Translation4,4’-二氨基二苯砜
Wiswesser Line NotationZR DSWR DZ
LabNetwork Molecule IDLN00142376
Canonical SMILESO=S(C1=CC=C(N)C=C1)(C2=CC=C(N)C=C2)=O
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分类

  • Pharmaceuticals
  • {SNA} Analytical Standards,
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; sulfone; 1fragment
  • {SNA} Additional Standards, Analytical Standards, Antibiotics Standards, Bacteriostatic, Chemical Structure, Chromatography, Clinical Standards, Others, Pharmaceuticals, Illicit Drugs & Alcohol, Principle, 分析/色谱
  • {SNA} Curing Agents for Epoxides, Materials Science, Polymer Additives, Polymer Science
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Bacteriostatic, Chemical Structure, Chromatography, Clinical Standards, D,
  • {SNA} Analyti
  • {SNA} Curing Agents for E

产品应用

  • 用于合成聚砜酰胺树脂及其他聚合物，抗麻风病类药。

相关文献及参考

  • [2]. Dapsone, Drug.com
  • [3]. D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9.
  • [4]. Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11(11):607.
  • ########
  • Merck: 14,2822
  • Merck: 14,2822 Beilstein: 13,536 / Beil. 13,IV,1306
  • Short: EINECS
  • Short: III/10a
  • Short: IV/8A
  • [1]. Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol
  • [1]. Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol
  • [2]. Dapsone, Drug.com
  • [3]. D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;

安全信息

Warnings IRRITANT
Signal word Warning {} {} {} {} {} {} {} {TCI}
GHS Symbol
WGK Germany1
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P312
  • P301+P312+P330
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P307+P311
  • P308+P311
  • P332+P313
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Hazard Codes Xn
RTECSBY8925000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} { {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {}
Packing GroupIII
Hazard Class9
UN Number 3249 3077 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 21840 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Blood - tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   25,619,1987

{h

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 20 gm/kg/80W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Blood - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-20,1977

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 39 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Blood - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-20,1977

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 78450 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Endocrine - thyroid tumors
REFERENCE :
   ALEPA8 Acta Leprologica.  (3, pl. Claparede, 1205 Geneva, Switzerland) No.1-
      1960-  Volume(issue)/page/year: 53,11,1973

TYPE OF TEST            : TDLo - Lowest published tox

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 5,213,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   28,313,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   HUTODJ H

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 300 mg/kg/21W-I
TOXIC EFFECTS :
   Blood - eosinophilia
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 343,860,1994

{

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 4 mg/L
REFERENCE :
   IJLEAG International Journal of Leprosy and Other Mycobacterial Diseases.
   (POB 1097, Bloomfield, NJ 07003)  V.1-    1933-  Volume(issue)/page/year:
   43,41,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2100 mg/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 81,259,1987

其他信息

  • Alfa Aesar:4,4'-二氨基二苯砜,98% 4,4'-Diaminodiphenyl sulfone, 98%(80-08-0)
  • MOL 文件:80-08-0.mol
  • 类别:有毒物品
  • 职业标准:STEL 5 毫克/立方米
  • 灭火剂:二氧化碳、砂土、干粉
  • 用途四:为治疗麻风病的首选药物，也可与其他抑制麻风病药联合应用
  • 海关编码:29309070
  • 检测方法:HPLC.NMR
  • 用途一:用作气相色谱固定液、有机合成中间体及环氧树脂固化剂
  • 用途二:要用于治疗各型麻风病。工业上用作环氧树脂的熟化剂等。
  • 急性毒性:口服-大鼠 LD50: 1000 毫克/公斤; 口服-小鼠 LD50: 250 毫克/公斤
  • 用途三:用作医药、高分子材料中间体
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • MSDS 信息:4,4'-二氨基二苯砜(80-08-0).msds
  • 不溶于水，溶于稀盐酸、乙醇、甲醇和丙酮。
  • Sigma Aldrich:80-08-0(sigmaaldrich)
  • 图谱信息:4,4'-二氨基二苯砜(80-08-0)红外图谱(IR2) 4,4'-二氨基二苯砜(80-08-0)红外图谱(IR1) 4,4'-二氨基二苯砜(80-08-0)核磁图( 1 HNMR) 4,4'-二氨基二苯砜(80-08-0)核磁图( 13 CNMR) 4,4'-二氨基二苯砜(80-08-0)质谱(MS)
  • 外观性质:白色或微黄色结晶性粉末，无气味，味苦。
  • TCI Shanghai:4,4'-二氨基二苯砜 Bis(4-aminophenyl) Sulfone,>;97.0%(T)(80-08-0)
  • 下游产品:
  • 毒性分级:高毒
  • 用途五:用于合成聚砜酰胺树脂及其他聚合物，抗麻风病类药。
  • Acros Organics:4,4'-二氨基二苯砜 4-Aminophenyl sulfone, 97%(80-08-0)
  • 4,4'-二氨基二苯砜价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 81006126 4，4-二氨基二苯砜 100g 46.2元 2011/04/16 D0089 双(4-氨苯基)砜 Bis(4-aminophenyl) Sulfone 25G 250元 2011/04/16 D0089 双(4-氨苯基)砜 Bis(4-aminophenyl) Sulfone 500G 1340元

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfones - Sulfur Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Clinical Standards - Chromatography
  5. Antibiotics - Clinical Standards
  6. Chemical Structure - Antibiotics
  7. Others - Chemical Structure
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Clinical Standards - Chromatography
  5. Antibiotics - Clinical Standards
  6. Principle - Antibiotics
  7. Bacteriostatic - Principle
  1. Materials Science 材料科学
  2. Products for Polymer Science Research
  3. Polymer Additives - Polymer Science
  4. Crosslinking Agents and Additives for Epoxides - Polymer Additives
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfoxides - Sulfur Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfonates/Sulfinates
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Polymers
  4. Polymer Additives
  5. Chain Transfer Agents
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)

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