3-Aminopropanol 3-氨基丙醇

CAS 156-87-6 MFCD00008223

化学结构图

156-87-6
SMILES: NCCCO

化学属性

Mol. FormulaC3H9NO
Mol. Weight75.11
Refractive index1.4580 to 1.4620
Boiling Point184-187°C at 760 mmHg
Density0.982
Melting Point10-12°C
Flash Point79.44°C
TSCAYes
Autoignition Point770 °F
Vapor Density2.59 (vs air)
Vapor Pressure2.1 mmHg ( 20 °C)
SolubilityMISCIBLE
Stability易吸潮
Appearance 无色液体。熔点12.4℃,沸点为187-188℃,相对密度0.9824(26/4℃),折光率1.4617,闪点79℃。能与水、醇、醚和氯仿混溶。有吸湿性。

别名和识别编码

Chemical Name3-Aminopropanol
Synonym 3-Aminopropan-1-ol {LY} 3-Aminopropan-1-ol 3-amino-1-propanol 3-aminopropan-1-ol {} {LY} 3-Aminopropan-1-ol {} {} {LY} 3-Aminopropan-1-ol {} {} {} {LY} 3-Aminopropan-1-ol {} {} {} {} {LY} 3-Aminopropan-1-ol {} {} {} {} {} {LY} 3-Aminopropan-1-ol {} {} {} {} {} {} {LY} 3-Aminopropan-1-ol {} {} {} {} {} {} {} {LY} 3-Aminopropan-1-ol {} {} {} {} {} {} {} {} {LY} 3-Aminopropan-1-ol {} {} {} {} {} {} {} {} {} {LY} 3-Aminopropan-1-ol {} {} {} {} {} {} {} {} {} {} {LY} 3-Aminopropan-1-ol {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Aminopropan-1-ol {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Aminopropan-1-ol {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Aminopropan-1-ol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Aminopropan-1-ol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Aminopropan-1-ol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Aminopropa
CAS Number156-87-6
PubChem Substance ID9086
EC Number205-864-4
Beilstein Registry Number4(4)1623
MDL NumberMFCD00008223
Reaxys-RN741855
Chemical Name Translation3-氨基丙醇
Wiswesser Line NotationZ3Q
LabNetwork Molecule IDLN00226237
InChIInChI=1S/C3H9NO/c4-2-1-3-5/h5H,1-4H2
Canonical SMILESOCCCN
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分类

  • A-B, Aliphatics, Alpha Sort, Amines, Analytical Standards, Analytical/Chromatography, Chemical Class, Chromatography,
  • {SNA} Analytical Standards,
  • {SNA} A-B, Additional Standards, Aliphatics, Alpha Sort, Amines, Analytical Standards, Chemical Class, Chromatography, Environmental Standards, Organic Pollutant Standards, Volatiles & Semivolatiles, Volatiles/ Semivolatiles, 分析/色谱
  • {SNA} Amino Alcohols
  • {uni_hamburg} no charge; alcohol; 1fragment
  • {SNA} A-B, A-C, Additional Standards, Aliphatics, Alpha Sort,
  • {SNA} A-B,
  • {SNA} Additional Standards,

产品应用

  • 用于合成环磷酰胺、心可定等药物,也可用于合成DL-泛醇

相关文献及参考

  • Short: II/25C
  • Short: II/14a
  • Short: II/2
  • Beilstein:4(4)1623

安全信息

GHS Symbol
WGK Germany1
Hazard Codes 8 C C,Xn
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H303 May be harmfully swallowed 吞食可能有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H332 Harmful if inhaled 吸入有害
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSUA5600000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P317
  • P301+P330+P331
  • P301+P330+P331+P310
  • P302+P352
  • P302+P361+P354
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P312
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P316
  • P317
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403 Store in a well-ventilated place. 储存在通风良好的地方。
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R34 Causes burns 会导致灼伤
UN Number 2735
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light Hygroscopic {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from li
Packing GroupII
Hazard Class8
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2830 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   23,95,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1250 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   23,95,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1202 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 97,1117,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 5700 ug/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 4,141,1971

其他信息

  • MOL 文件:156-87-6.mol
  • 蒸气密度:2.59 (vs air)
  • 图谱信息:3-氨基-1-丙醇(156-87-6)核磁图( 13 CNMR) 3-氨基-1-丙醇(156-87-6)红外图谱(IR1) 3-氨基-1-丙醇(156-87-6)核磁图( 1 HNMR) 3-氨基-1-丙醇(156-87-6)Raman光谱 3-氨基-1-丙醇(156-87-6)红外图谱(IR2) 3-氨基-1-丙醇(156-87-6)质谱(MS)
  • 用途二:用于有机合成
  • TCI Shanghai:3-氨基-1-丙醇 3-Amino-1-propanol,>;99.0%(GC)(T)(156-87-6)
  • 海关编码:29221980
  • 存储注意事项:湿度敏感
  • 蒸气压:2.1 mm Hg ( 20 °C)
  • 用途一:用于合成环磷酰胺、心可定等药物,也可用于合成DL-泛醇
  • MSDS 信息:3-Amino-1-Propanol(156-87-6).msds
  • Sigma Aldrich:156-87-6(sigmaaldrich)
  • 用途三:可用有机合成的中间体。用于合成环磷酰胺、心可定等药物。
  • 敏感性:Hygroscopic
  • Alfa Aesar:3-氨基-1-丙醇,98% 3-Amino-1-propanol, 99%(156-87-6)
  • Acros Organics:3-氨基-1-丙醇 3-Amino-1-propanol, 99%(156-87-6)
  • 3-氨基-1-丙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 C104465000 3-氨基-1-丙醇;3-氨基丙醇;3-羟基丙胺;γ-丙醇胺 500ml 537元 2011/08/23 LB2304101 3-氨基-1-丙醇;3-氨基丙醇;3-羟基丙胺;γ-丙醇胺 100g 239元 2011/08/23 30157327 正丙醇胺 250ml 120.5元
  • 上游原料:L-丙氨酸
  • 能与水、醇、醚、丙酮和氯仿混溶,微溶于芳香烃和脂肪烃。有吸湿性。略带氨味
  • 方法一:由β-羟基丙腈化催化加氢而得。将β-羟基丙腈、阮尼镍和乙醇、氨加入高压釜中,通氢气至2.94MPa,于100-120℃保持氢气压力,至不吸氢后继续保温2h。反应结束后降温,过滤回收阮尼镍,将滤液减压蒸馏,收集90-92℃/2.0kPa馏分而得,含量95%以上,收率接近70%。
  • 下游产品:杂氮环丁烷

系列性分类