Spermidine 亚精胺

CAS 124-20-9 MFCD00008229

化学结构图

124-20-9
SMILES: NCCCCNCCCN

化学属性

Mol. FormulaC7H19N3
Mol. Weight145.25
Density0.925
Refractive indexn20/D 1.479(lit.)
Melting Point23-25°C
Flash Point> 110 °
TSCAYes
Boiling Point129 °C at 760 mmHg
Stability对空气敏感
SolubilityH2O: 1 M at 20 °C, clear, colorless

别名和识别编码

Chemical NameSpermidine
CAS Number124-20-9
Synonym Spermidine {Chemicalbook} 1,5,10-triazadecane 1,8-DIAMINO-4-AZAOCTANE 4-azaoctamethylenediamine Additive Screening Solution 30/Fluka kit no 78374 Additive Screening Solution 30/Kit-No 78374 N-(3-Aminopropyl)-1,4-butanediamine; 1,8-Diamino-4-azaoctane N-(3-Aminopropyl)-1,4-diaminobutane N-(3-Aminopropyl)-1,4-diaminobutane~1,8-Diamino-4-azaoctane N-(3-氨基丙基) N-(3-氨基丙基)-1,4-丁二胺 N-[3-AMINOPROPYL]-1,4-BUTANEDIAMINE N1-(3-AMINOPROPYL)BUTANE-1,4-DIAMINE OMEGA-AMINOBUTYL-OMEGA-AMINOPROPYLAMINE SPERMIDINE FREE BASE SPERMIDINE FREE BASE CELL CULTURE*TESTED SPERMIDINE FREE BASE MOLECULAR BIOLOGY*R EAGENT SPERMIDINE, FOR MOLECULAR {} {hazard_com} 1,5,10-Triazadecane {} {} {hazard_com} 1,4-Diaminobutane, N-(3-aminopropyl)- {} {} {} {Chemicalbook} 1,4
MDL NumberMFCD00008229
EC Number204-689-0
Beilstein Registry Number1698591
PubChem Substance ID1102
Merck Number14,8742
Chemical Name Translation亚精胺
Wiswesser Line NotationZ4M3Z
LabNetwork Molecule IDLN00195226
InChIInChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
Canonical SMILESNCCCCNCCCN
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分类

  • {SNA} App
  • {SNA} Amine Standards, Analytical Standards, Food and Cosmetic Component Standards, 分析/色谱
  • {S
  • {SNA} Application Index, Cell Signaling Enzymes, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, L to O, NOS Inhibitors, Nitric Oxide Metabolism, Nitric Oxide Synthase Regulators, Nitric Oxide Synthase neuronal, 一氧化氮代谢, 一氧化氮和细胞应激, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • {SNA} Application Index, Cell Signaling Enzymes, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, L to O, NOS - Nitric Oxide Inhibitors,

产品应用

  • 抑制神经元NO合成酶(nNOS)。结合并沉淀DNA; 也用于纯化DNA结合蛋白。刺激T4 聚核苷酸激酶活性。

相关文献及参考

  • Abraham, A.K., et al.: Eur. J. Biochem., 106, 257 (1980),
  • Mach, M., et al.: Biochem. J., 202, 153 (1982),
  • Merck: 14,8742
  • Merck: 14,8742 Beilstein: 4,IV,1300
  • Thyss, A., et al.: Eur. J. Cancer Clin. Oncol., 18, 611 (1982),
  • [1]. Zhang L, et al.  The Alleviation of Heat Damage to Photosystem II and Enzymatic Antioxidants by Exogenous Spermidine in Tall Fescue. Front Plant Sci. 2017 Oct 12;8:1747.

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S20 When using do not eat or drink 使用时，不得进食，饮水；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R34 Causes burns 会导致灼伤
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P303+P361+P353
  • P304+P340
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H318 Causes serious eye damage 严重伤害眼睛
Personal Protective Equipment Faceshields, Gloves, Goggles Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSEJ7000000
Packing GroupII
UN Number 2735
Storage condition 2-8°C {LY} 2-8°C 4 4°C, Hygroscopic 4℃ Air Sensitive {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} +4°C 储存温度 2-8°C 储存温度 2-8°C，对空气敏感
Hazard Codes 8 C
Hazard Class8 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 78 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 198,36,1972

TYPE OF TEST            : LD30 - Lethal Dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AGACBH Agents and Actions, A Swiss Journal of Pharmacology.  (Birkhaeuser
   Verlag, POB 133, CH-4010 Basel, Switzerland)  V.1-    1969/70-
   Volume(issue)/page/year: 14,228,1984

TYPE OF TEST            : LD30 - Lethal Dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AGACBH Agents and Actions, A Swiss Journal of Pharmacology.  (Birkhaeuser
   Verlag, POB 133, CH-4010 Basel, Switzerland)  V.1-    1969/70-
   Volume(issue)/page/year: 14,228,1984

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lung
DOSE/DURATION           : 200 mmol/L
REFERENCE :
   IJRBA3 International Journal of Radiation Biology and Related Studies in
   Physics, Chemistry and Medicine.  (Taylor & Francis Inc., 242 Cherry St.,
   Philadelphia, PA 19106)  V.1-    1959-  Volume(issue)/page/year: 9,185,1965

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   AMOKAG Acta Medicia Okayama.  (Okayama Univ. Medical School, Okayama, Japan)
    V.27    1973-  Volume(issue)/page/year: 33,149,1979

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 300 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   46,175,1986

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Liver
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   AMOKAG Acta Medicia Okayama.  (Okayama Univ. Medical School, Okayama, Japan)
    V.27    1973-  Volume(issue)/page/year: 33,149,1979

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MGGEAE Molecular and General Genetics.  (Springer-Verlag, Heidelberger Pl.
   3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.99-    1967-
   Volume(issue)/page/year: 178,21,1980

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 4 mmol/L
REFERENCE :
   BIJOAK Biochemical Journal.  (Biochemical Soc. Book Depot, POB 32, Commerce
   Way, Colchester, Essex CO2 8HP, UK)  V.1-    1906- Volume(

其他信息

  • Sigma Aldrich:124-20-9(sigmaaldrich)
  • F:3-10-34
  • 敏感性:Air Sensitive
  • Acros Organics:亚精胺 Spermidine, 99%(124-20-9)
  • 用途一:抑制神经元NO合成酶(nNOS)。结合并沉淀DNA; 也用于纯化DNA结合蛋白。刺激T4 聚核苷酸激酶活性。
  • 上游原料:四氢呋喃 --> 氢化铝锂 --> 氢化钠 --> 二碳酸二叔丁酯 --> 四亚甲基二胺 --> 3-溴丙腈
  • MOL 文件:124-20-9.mol
  • 亚精胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 LA1909601 亚精胺;精脒;α-(γ-氨基丙氨)-δ-氨基丁烷;1,8-二氨基-4-氮辛烷;N-(3-氨丙基)-1,4-丁二胺 1g 238元 2011/08/23 30171080 精脒(+4℃) 5g 383.8元 2010/06/21 132740050 亚精胺 Spermidine 99% 5 GR 1095元
  • Alfa Aesar:亚精胺,99% Spermidine, 99%(124-20-9)
  • 图谱信息:亚精胺(124-20-9)红外图谱(IR1) 亚精胺(124-20-9)质谱(MS)
  • 溶于水、醇和醚。

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. S - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. DNA & RNA Purification - Molecular Biology
  4. Reagents - DNA & RNA Purification
  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. Molecular Biology Reagents - Molecular Biology
  4. Biochemicals - Molecular Biology Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amidates/Imidates - Nitrogen Compounds
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Substrate Analogs - Enzyme Inhibitors by Type
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. L to O - Enzyme Inhibitors by Enzyme
  7. Nitric Oxide Synthase neuronal - L to O
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Cell Signaling Enzymes - Application Index
  6. Nitric Oxide Metabolism - Cell Signaling Enzymes
  7. NOS Inhibitors - Nitric Oxide Metabolism
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. BioChemika Ultra
  4. Crystallization
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Molecular Biology
  4. Molecular Biology Reagents
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Type
  6. Other
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Nitric Oxide and Cell Stress
  5. Nitric Oxide Metabolism
  6. Nitric Oxide Scavengers
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Nitric Oxide Metabolism
  6. NO Donors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Nitric Oxide Synthase (iNOS)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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