Ethylene glycol dimethyl ether 乙二醇二甲醚

CAS 110-71-4 MFCD00008502

化学结构图

110-71-4
SMILES: COCCOC

化学属性

Mol. FormulaC4H10O2
Mol. Weight90.12
Refractive index1.3790 to 1.3810
Boiling Point85
Density0.867
Melting Point-58
Flash Point0°C
TSCAYes
Autoignition Point396 °F
Vapor Density3.1 (20 °C, vs air)
Vapor Pressure48 mmHg ( 20 °C)
Solubility溶于水、烃类。
Stability对湿度敏感
Danger-Level甲类

别名和识别编码

Chemical NameEthylene glycol dimethyl ether
Synonym 2,5-Dioxahexane {LY} 2,5-Dioxahexane 2,5-dioxahexane Ansol E-121 CH3OCH2CH2OCH3 DME DME (glycol ether) DMEEthylene glycol dimethyl ether Dimethyl Dimethyl Cellosolve, Methyl Glycol Dimethyl Cellosolve, methyl Glycol Dimethyl cellosolve, Methyl glycol Dimethylglykol ETHYLENE GLYCOL DIMETHYL ETHER Egdme Ethane, 1,2-dimethoxy- Ethane-1,2-diol dimethyl ether Ethylene glycol dimethylether Glyme alpha,beta-Dimethoxyethane ethylene glycol dimethyl ether {} {LY} 2,5-Dioxahexane {} {} {LY} 2,5-Dioxahexane {} {} {} {LY} 2,5-Dioxahexane {} {} {} {} {LY} 2,5-Dioxahexane {} {} {} {} {} {LY} 2,5-Dioxahexane {} {} {} {} {} {} {LY} 2,5-Dioxahexane {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {LY} 2,5-Dioxahexane {} {} {} {} {} {} {} {} {LY}
CAS Number110-71-4
PubChem Substance ID87567280
EC Number203-794-9
Beilstein Registry Number1209237
MDL NumberMFCD00008502
Reaxys-RN1209237
Merck Number3224
Chemical Name Translation乙二醇二甲醚
Wiswesser Line Notation1O2O1
LabNetwork Molecule IDLN00164056
InChIInChI=1S/C4H10O2/c1-5-3-4-6-2/h3-4H2,1-2H3
Canonical SMILESCOCCOC
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分类

  • {SNA} Additional Standards, Alpha Sort, Analytical Standards, Chemical Class, Chromatography, D, Environmental Standards, Food and Cosmetic Component Standards, Organic Pollutant Standards, Solvents, Standards for Personal Care and Cosmetic Products, Volatile & Semivolatile Standards, Volatiles/ Semivolatiles, neats, prohibited substances (EU-REGULATION No 1223/2009), 分析/色谱
  • {uni_hamburg} no charge; ether; 1fragment
  • {SNA} Alternative Energy, Anhydrous, Anhydrous Solvents, Electrolytes, Organic Solvents, Returnable Containers, Solvent Bottles, Solvent Packaging Options,

产品应用

  • 用作溶剂和有机合成中间体。

相关文献及参考

  • Short: II/25C
  • Merck:14,3224
  • Solvent for lithiations and metal hydride reductions.
  • Merck:14,3224 Beilstein:1,467
  • Recommended solvent for the Schmidt reaction of ketones with hydrazoic acid, avoiding potential hazards reported with the more usual chlorinated solvents, particularly chloroform. The hydrazoic acid is generated in situ from NaN3 and methanesulfonic acid: Tetrahedron, 52, 1609 (1996).

安全信息

GHS Symbol
WGK Germany1
Hazard Codes 3 F,T F;T
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H332 Harmful if inhaled 吸入有害
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSKI1451000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241+P242+P243
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P303+P361+P353
  • P308+P313
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P370+P378
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Risk Statements
  • R11 Highly flammable 非常易燃
  • R19 May form explosive peroxides 可能生成易爆的过氧化物质
  • R20 Harmful by inhalation 吸入有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R38 Irritating to skin 刺激皮肤
  • R60 May impair fertility 可能降低生殖能力
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
UN Number 2252 UN2252
Packing GroupII
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Hazard Class3
Warnings 危化品目录(2015)
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0539769

TYPE OF TEST            : LD50 - Let

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0539769

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0571323

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0571323

{hazar

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 660 mg/kg
SEX/DURATION            : female 8-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   REPTED Reproductive Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1987-  Volume(issue)/page/year:
   5,157,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1400 mg/kg
SEX/DURATION            : female 7-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   NISFAY Nippon Sanka Fujinka Gakkai Zasshi.  Journal of the Japan Society of
   Obstetrics and Gynecology.  (Nippon Sanka Fujinka Gakkai Zasshi, Hoken
   Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan)
   V.1-    1949-  Volume(issue)/page/year: 32,113,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 660 mg/kg
SEX/DURATION            : female 8-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   REPTED Reproductive Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1987-  Volume(issue)/page/year:
   5,157,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Ro

Restrict 危险品

其他信息

  • 灭火剂:干粉、干砂
  • 用途一:主要用于聚合物化学、电化学、硼化学工艺领域,还用作树脂、硝化纤维素等的溶剂
  • 毒性分级:中毒
  • 海关编码:29091900
  • 是一类性能优良的非质子极性溶剂。有强烈醚样气味同,有吸湿性,能与水及碳氢化合物混溶,溶于烃类溶剂。易燃。半数致死量(大鼠,经口)8g/kg。
  • TCI Shanghai:乙二醇二甲醚 1,2-Dimethoxyethane,>;99.0%(GC)(110-71-4)
  • 图谱信息:乙二醇二甲醚(110-71-4)红外图谱(IR1) 乙二醇二甲醚(110-71-4)核磁图( 13 CNMR) 乙二醇二甲醚(110-71-4)Raman光谱 乙二醇二甲醚(110-71-4)质谱(MS) 乙二醇二甲醚(110-71-4)核磁图( 1 HNMR)
  • 乙二醇二甲醚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 C118450010 乙二醇二甲醚;1,2-二甲氧基乙烷;二甲基溶纤剂 1L 1146元 2011/08/23 80062018 乙二醇二甲醚;1,2-二甲氧基乙烷;二甲基溶纤剂 500ml 129.2元 2011/08/23 80062028 乙二醇二甲醚;1,2-二甲氧基乙烷;二甲基溶纤剂 500ml 93元
  • 方法一:由乙二醇单甲醚与金属钠、氯甲烷反应而得。将乙二醇单甲醚与金属钠一起回流,直至金属钠完全反应,降温至45℃,通入氯甲烷。反应毕,进行分馏,收集84-85.5℃馏分,即得成品。
  • 是一类性能优良的非质子极性溶剂。有强烈醚样气味同,有吸湿性,能与水及碳氢化合物混溶,溶于烃类溶剂。易燃。半数致死量(大鼠,经口)7g/kg。
  • 检测方法:GC,NMR
  • 用途二:主要用作溶剂和有机合成中间体
  • Alfa Aesar:1,2-二甲氧基乙烷,99+%,stab.with0.01%BHT 1,2-Dimethoxyethane, 99+%, stab. with 0.01% BHT(110-71-4)
  • Sigma Aldrich:110-71-4(sigmaaldrich)
  • 蒸气密度:3.1 (20 °C, vs air)
  • 是一类性能优良的非质子极性溶剂。有强烈醚样气味同,有吸湿性,能与水及碳氢化合物混溶,溶于烃类溶剂。易燃。半数致死量(大鼠,经口)12g/kg。
  • 类别:易燃液体
  • 上游原料:氢氧化钠 --> 乙二醇甲醚
  • 可燃性危险特性:遇明火、高温、氧化剂易燃;
  • Acros Organics:乙二醇二甲醚 Ethyleneglycoldimethylether,stabilizedwithBHT,extrapure,99+%(110-71-4)
  • 用途三:用作溶剂和有机合成中间体。
  • 是一类性能优良的非质子极性溶剂。有强烈醚样气味同,有吸湿性,能与水及碳氢化合
  • F:3-10-23
  • 下游产品:杂氮环丁烷 --> 3-N-叔丁氧羰基胺基环丁胺 --> DCJTB --> 颜料红 122 --> 3-氨基联苯 --> 2-氨基喹啉 --> 喹吖啶酮 --> 3,4-二氯-N-甲基苯胺 --> 4-氯-7-甲基噻吩并[3,2-D]嘧啶 --> 4'-溴-3'-氟乙酰苯胺 --> 2-苯基丙二酰胺 --> 2-溴-5-羟基吡啶 --> 三3-(三氟甲基羟基亚甲基)-D-樟脑 铕 --> 2-氯-5-碘-3-甲基吡啶 --> 4-氯-1,3-二甲基-1H-吡唑3,4-吡啶-5-羧酸 --> N-甲基吲哚-5-硼酸 --> N,N'-二甲基喹吖啶酮 --> 3-三氟乙酰基-D-樟脑 --> 10-十一碳炔酸 --> 1,7-双(4-羟基-3-甲氧基苯基)庚烷-3,5-二酮 --> 叔丁基4-(4-甲酸基-1,3-噻唑-2-基)哌啶-1-甲酸酯 --> 4-(5-醛基-4-甲基-1,3-噻吩-2-基)哌啶-1-甲酸叔丁基酯 --> 贝前列素 --> 替马沙星 --> 沙拉沙星 --> 4-甲

系列性分类