Tri(o-tolyl)phosphine 三(邻甲苯基)膦

CAS 6163-58-2 MFCD00008514

化学结构图

6163-58-2
SMILES: Cc1ccccc1P(c1ccccc1C)c1ccccc1C

化学属性

Mol. FormulaC21H21P
Mol. Weight304.37
Density1.589
Melting Point123-125
TSCAYes
Boiling Point412.4±44.0 °C at 760 mmHg
Appearance 白色晶体
Stabilityair sensitive

别名和识别编码

Chemical NameTri(o-tolyl)phosphine
CAS Number6163-58-2
Alfabeta NameTRITOLYLPHOSPHINE M()-
MDL NumberMFCD00008514
Synonym Tri(2-methylphenyl)phosphine {LY} Tri(2-methylphenyl)phosphine {} {LY} Tri(2-methylphenyl)phosphine {} {} {LY} Tri(2-methylphenyl)phosphine {} {} {} {LY} Tri(2-methylphenyl)phosphine {} {} {} {} {LY} Tri(2-methylphenyl)phosphine {} {} {} {} {} {LY} Tri(2-methylphenyl)phosphine {} {} {} {} {} {} { {} {} {} {} {} {} {LY} Tri(2-methylphenyl)phosphine {} {} {} {} {} {} {} {LY} Tri(2-methylphenyl)phosphine {} {} {} {} {} {} {} {} {LY} Tri(2-methylphenyl)phosphine {} {} {} {} {} {} {} {} {} {LY} Tri(2-methylphenyl)phosphine {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} Tri(2-methylphenyl)phosphine {} {} {} {} {} {} {} {} {} {} {} {LY} Tri(2-methylphenyl)phosphine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tri(2-methylphenyl)phosphine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tri(2-methylphenyl)phosphine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tri(2-methylphen
EC Number228-193-9
Beilstein Registry Number661212
PubChem Substance ID80271
Reaxys-RN661212
Chemical Name Translation三(邻甲苯基)膦
InChIKeyCOIOYMYWGDAQPM-UHFFFAOYSA-N
LabNetwork Molecule IDLN00173237
InChIInChI=1S/C21H21P/c1-16-10-4-7-13-19(16)22(20-14-8-5-11-17(20)2)21-15-9-6-12-18(21)3/h4-15H,1-3H3
Canonical SMILESCC1=C(C=CC=C1)P(C(C=CC=C2)=C2C)C(C=CC=C3)=C3C
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分类

  • {SNA} Basic Phosphine Ligands, Catalysis and Inorganic Chemistry, Chemical Synthesis, Cross-Coupling, Phosphine Compounds, Phosphine Ligands
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment

产品应用

  • 配体，用于钌催化的醇的氨基化反应。

相关文献及参考

  • Short: III/10b
  • Short: EINECS
  • Preferred phosphine ligand for use in combination with Pd salts in the Heck-type coupling reactions of vinylic halides. For examples, see Palladium(II)­ acetate, 10516. For a review of the Heck reaction, see: Org. React., 27, 345 (1982).
  • The Pd-catalyzed amination of bromoarenes with 1-Boc-piperazine, L13363, in the presence of this ligand, provides a route to arylpiperazines of potential pharmacological interest: Tetrahedron Lett., 39, 2219 (1998).
  • Beilstein: 16,III,835

安全信息

Warnings IRRITANT
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S37 Wear suitable gloves 戴适当手套；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Storage condition 2-8°C, protect from light, stored under nitrogen {LY} 2-8°C, protect from light, stored under nitrogen {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitr

其他信息

  • 下游产品:5-甲基吲哚
  • 存储注意事项:光敏感
  • Sigma Aldrich:6163-58-2(sigmaaldrich)
  • 上游原料:乙醇 --> 氢氧化钠 --> 盐酸 --> 乙酸乙酯 --> 乙醚 --> 四氢呋喃 --> 二氯甲烷 --> 石油醚 --> 硫酸钠 --> 氯化钠 --> 氯化铵 --> 镁 --> 三氯化磷 --> 碘 --> 1,2-二溴乙烷 --> 左旋酒石酸 --> 2-溴甲苯
  • Acros Organics:三(邻-甲苯基)磷 Tri-o-tolylphosphine, 99%(6163-58-2)
  • 三(邻甲基苯基)磷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T1024 三(2-甲苯基)膦 Tris(2-methylphenyl)phosphine 25G 1320元 2014/06/02 T1024 三(2-甲苯基)膦 Tris(2-methylphenyl)phosphine 5G 484元 2010/06/21 422320010 三(邻甲基苯基)磷 Tri-o-tolylphosphine 99% 1 GR 328元
  • F:10-23
  • 用途二:配体，用于钌催化的醇的氨基化反应。
  • MOL 文件:6163-58-2.mol
  • Alfa Aesar:三(邻甲苯)膦,98+% Tri(o-tolyl)phosphine, 98+%(6163-58-2)
  • 检测方法:HPLC,NMR
  • TCI Shanghai:三(2-甲基苯基)膦 Tris(2-methylphenyl)phosphine,>;95.0%(GC)(6163-58-2)
  • 用途一:作为配体，用于偶联反应中

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Phosphorus Compounds 磷化合物
  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Cross-Coupling - Catalysis and Inorganic Chemistry
  4. Basic Phosphine Ligands - Cross-Coupling
  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Phosphorus Compounds Catalysis 磷化合物催化剂
  4. Phosphine Ligands 膦配体
  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Cross-Coupling 交叉偶联
  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Phosphorus Compounds
  4. Elemental Phosphorus
  1. Functional Group 官能团索引
  2. phosphine
  1. Phosphine
  2. Phosphorus
  1. Ligands
  2. Phosphorus
  1. Ligands
  2. 96-1650 Phosphine Ligand Kit for Palladium-Catalyzed Carbon-Carbon and Carbon-Heteroatom Bond Formation
  1. Phosphine
  2. 96-1650 Phosphine Ligand Kit for Palladium-Catalyzed Carbon-Carbon and Carbon-Heteroatom Bond Formation