N-(Trimethylsilyl)Acetamide N-(三甲基硅基)乙酰胺
CAS 13435-12-6 MFCD00008671
化学结构图
SMILES: CC(=O)N[Si](C)(C)C
化学属性
| Mol. Formula | C5H13NOSi |
|---|---|
| Mol. Weight | 131.25 |
| Boiling Point | 84 °C/18 mmHg(lit.) |
| Melting Point | 46-49 °C(lit.) |
| Flash Point | 70°(158°F) |
| TSCA | Yes |
| Solubility | 起反应 |
别名和识别编码
| Chemical Name | N-(Trimethylsilyl)Acetamide |
|---|---|
| Synonym | N-TrimethylsilylacetamideA.R. N-TMS-acetamide N-TRIMETHYLSILYLACETAMIDE N-(Trimethylsilyl)acetamide TMS 乙酰胺 (Acetylamino)trimethylsilane (acetylamino)trimethylsilane TMS-acetamid n-(trimethylsilyl)-acetamid N-trimethylsilyl-acetamide TRIMETHYLSILYLACETAMIDE trimethylsilyl N-(三甲基硅基)乙酰胺 N-TRIMETHYLSILYL ACETAMIDE(TMSA) N-trimethylsilanyl-acetamide Trimethylsilylacetamide N-三甲基硅基乙酰胺 TMSA N-Trimethylsilylacetamide Acetamide, N-(trimethylsilyl)- N-(Trimethylsilyl)-acetamid TMS ACETAMIDE |
| MDL Number | MFCD00008671 |
| Beilstein Registry Number | 741928 |
| EC Number | 236-565-7 |
| CAS Number | 13435-12-6 |
| PubChem Substance ID | 87576487 |
| Chemical Name Translation | N-(三甲基硅基)乙酰胺 |
| Reaxys-RN | 741928 |
| Wiswesser Line Notation | 1VM-SI-1&1&1 |
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分类
- {SNA} Acyclic, Alkenes, Building Blocks, Chemical Synthesis, Organic Building Blocks
- {SNA} Derivatization Reagents, Derivatization Reagents GC, Reagents for Silylation, 分析/色谱, 分析试剂
- {uni_hamburg} no charge; amide; 1fragment
相关文献及参考
- Short: III/35F
- n-BuLi forms the dilithio-derivative which can act as a soluble enolate equivalent of acetamide, reacting with electrophiles at carbon: J. Org. Chem., 49, 2015 (1984).
- Used in combination with triflic anhydride for N-glycosylation of sugars: J. Am. Chem. Soc., 111, 6881 (1989).
- Short: EINECS
- Mild reagent for the silylation (see Appendix 4) of alcohols, including carbohydrates; cf N,O-Bis(trimethylsilyl)acetamide, L00183. O-Silylation in the presence of TBAB (0.02 equiv.) occurs under very mild conditions: Tetrahedron Lett., 35, 8409 (1994).
安全信息
GHS Symbol
Precautionary statements
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
Hazard statements
- H228 Flammable solid 易燃固体
WGK Germany3
Personal Protective Equipment
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Signal word
Warning
RTECSAD0250000
Safety Statements
- S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S37 Wear suitable gloves 戴适当手套；
Risk Statements
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R11 Highly flammable 非常易燃
Storage condition
Moisture Sensitive
Hazard Codes
F;Xi
Xi-F
F
Packing GroupIII
UN Number
1325
Hazard Class4.1
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Immunological Including Allergic - decreased immune response REFERENCE : StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975 Volume(issue)/page/year: 27MAY1975
其他信息
- Sigma Aldrich:13435-12-6(sigmaaldrich)
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