Diisopropyl fluorophosphate 氟磷酸二异丙酯(禁运)

CAS 55-91-4 MFCD00008873

化学结构图

55-91-4
SMILES: CC(C)OP(=O)(F)OC(C)C

化学属性

Mol. FormulaC6H14FO3P
Mol. Weight184.17
Refractive indexn20/D 1.385(lit.)
Boiling Point62 °C/9 mmHg(lit.)
Density1.06 g/mL at 25 °C(lit.)
Melting Point-82 °C(lit.)
Vapor Pressure0.58 mmHg ( 20 °C)
Solubility微溶于水,溶于醇、醚、氯仿。

别名和识别编码

Chemical NamePhosphorofluoridic acid, bis(1-methylethyl) ester
CAS Number55-91-4
Synonym Bis(1-methylethyl) Phosphorofluoridate DFF DFP DFP DIFP 二异丙基氟磷酸酯 氟代磷酸二异丙酯 DFP (pesticide) DIISOPROPYL PHOSPHOROFLUORIDATE Di isopropylphosphorofluoridate Di-isopropylphosphorofluoridate Difluorophate Diflupyl Difluropha Diflurophate Diisop Diisopropyl fluoridophosphate Diisopropyl fluorophosphate Diisopropyl fluorophosphonate Diisopropyl phosphofluoridate Diisopropyl phosphorofluoridate Diisopropyl-fluorophosphat Diisopropylfluorop Diisopropylfluorophosphate Diisopropylfluorophosphoric acid ester Diisopropylfluorphosphat Diisopropylfluorphosphorsaeureester Diisopropylphosphofluoridate Diisopropylphosphorfluoridat {PubChem
PubChem Substance ID5936
EC Number200-247-6
Beilstein Registry Number1723307
MDL NumberMFCD00008873
Chemical Name Translation氟磷酸二异丙酯(禁运)
Merck Number13,5194
Wiswesser Line Notation1Y1&OPO&FOY1&1
InChIInChI=1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3
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分类

  • Inhibitors
  • {uni_hamburg} no charge; 1fragment
  • {SA} Bioactive Small Molecules, Building Blocks, Cell Biology, Chemical Synthesis, DIG-DY, Organic Building Blocks, Phosphorus Compounds, Phosphorus Halides
  • {SNA} A to C, Acetylcholinesterase, Analytical and Industrial Enzymes, Apoptosis Enzymes, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Broad Spectrum Inhibitors of Proteolytic Enzyme Classes, Carboxypeptidase P, Carboxypeptidase Y, Cathepsin G, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Chymotrypsin, α-,

产品应用

  • A potent inhibitor of serine proteases such as trypsin and chymotrypsin, and of acetylcholinesterase.

相关文献及参考

  • Sarin, A., et al.: J. Exp. Med., 178, 1693 (1993),
  • Short: III/35A Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts and Coupling Constants for Boron-11 and Phosphorus-31 Author: Gupta, R.R.; Jain, M.; Pardasani, P.; Pardasani, R.T.; Pelter, A. Editor: Gupta, R.R.; Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/35A Year: 1997 ISBN: 3-540-60366-2 ISBN: 978-3-540-60366-5 Internet Resource: DOI:10.1007/b53033 RefComment: VIII, 242 pages. With CD-ROM. Hardcover Abstract: This volume provides a comprehensive and evaluated compilation of nuclear magnetic resonance data. Chemical shifts and coupling constants of boron-11 and phosphorus-31 (subvol. A), fluorine-19 and nitrogen-15 (subvol. B), hydrogen-1 (subvol. C), and carbon-13 (subvol. D) compounds are tabulated together with the gross- and structure formulas and the most readily available solvents. Due to the large amount of the data merely chemical shifts are presented in the printed versions, and all the data, chemical shifts and coupling constants are provided on CO-ROM's.
  • Short: IV/16 Title: Surface tension of pure liquids and binary mixtures Author: Wohlfarth, Ch.; Wohlfarth, B. Editor: Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: IV/16 Year: 1997 Keyword: organic compounds; surface tension; liquids; mixtures ISBN: 3-540-63276-X ISBN: 978-3-540-63276-4 Internet Resource: DOI:10.1007/b60566 RefComment: VII, 439 pages.
  • Short: IV/18A Title: Viscosity of Pure Organic Liquids and Binary Liquid Mixtures: Pure Organometallic and Organononmetallic Liquids, Binary Liquid Mixtures Author: Wohlfarth, Ch.; Wohlfarth, B. Editor: Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: IV/18A Year: 2001 Keyword: organic compounds; viscosity; liquids; mixtures ISBN: 3-540-64584-5 ISBN: 978-3-540-64584-9 Internet Resource: DOI:10.1007/b68239 RefComment: VII, 409 pages.
  • Short: IV/20A Title: Vapor Pressure and Antoin

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T+
Hazard statements
  • H300 Fatal if swallowed 吞食致命
  • H300+H310+H330
  • H310 Fatal in contact with skin 皮肤接触致命
  • H330 Fatal if inhaled 吸入致命
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSTE5075000
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P302+P350
  • P304+P340
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Packing GroupI
Hazard Class6.1(a)
Storage condition 2-8°C
UN Number UN 3382 6.1/PG 1
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有剧毒
Restrict 剧毒化学品
Warnings 危化品目录(2015) 危险化学品
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DEGEA3 Deutsche Gesundheitswesen.  (VEB Verlag Volk und Gesundheit, Neue
   Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-
   Volume(issue)/page/year: 15,2179,1960

TYPE OF TEST            : LC50 - Lethal concentration,

{hazard_c

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 440 mg/m3/10M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 157,287,1946

TYPE OF TEST            : LD50 - Lethal do

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(is

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Ocular
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1150 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 87,414,1946

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 500 ug/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 31,596,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 mg/kg
SEX/DURATION            : female 6-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   5,S204,1985

其他信息

  • 灭火剂:砂土、干粉、泡沫
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 类别:农药
  • 毒性分级:剧毒
  • 外观性质:无色油状液体,易潮解。
  • 蒸气压:0.58 mm Hg ( 20 °C)
  • MSDS 信息:氟磷酸异丙酯(55-91-4).msds
  • F:10-21
  • MOL 文件:55-91-4.mol
  • 氟磷酸二异丙酯(禁运)价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80058280 氟磷酸二异丙酯(剧毒) g 55元 2010/06/21 115230010 氟磷酸二异丙酯(禁运) Diisopropyl fluorophosphate 99% 1 GR 3460元
  • Acros Organics:氟磷酸二异丙酯(禁运) Diisopropylfluorophosphate,99%(55-91-4)
  • 可燃性危险特性:明火可燃; 受热放出有毒氧化磷、氟化物气体
  • Sigma Aldrich:55-91-4(sigmaaldrich)
  • 急性毒性:口服-大鼠 LD50: 5 毫克/公斤; 口服-小鼠 LD50: 2 毫克/公斤

系列性分类


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