Carbonyl Cyanide 4-(Trifluoromethoxy)phenylhydrazone [4-(三氟甲氧基)苯基亚肼基]丙二腈

CAS 370-86-5 MFCD00009699

化学结构图

370-86-5
SMILES: N#CC(C#N)=NNc1ccc(OC(F)(F)F)cc1

化学属性

Mol. FormulaC10 H5 F3 N4 O
Mol. Weight254.168
Melting Point174-175 °C (dec.)(lit.)

别名和识别编码

Chemical NameCarbonyl Cyanide 4-(Trifluoromethoxy)phenylhydrazone
CAS Number370-86-5
MDL NumberMFCD00009699
Synonym (4-(Trifluoromethoxy)phenyl)hydrazonopropanedinitrile Carbonyl Cyanide 4-(Trifluoromethoxy)phenylhydrazone Carbonyl Cyanide p Trifluoromethoxyphenylhydrazone Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone Carbonyl Cyanide para Trifluoromethoxyphenylhydrazone Carbonyl Cyanide para-Trifluoromethoxyphenylhydrazone Cyanide p-Trifluoromethoxyphenylhydrazone, Carbonyl Cyanide para-Trifluoromethoxyphenylhydrazone, Carbonyl FCCP {} {} {} {PubChem} para-Trifluoromethoxyphenylhydrazone, Carbonyl Cyanide {} {} {} {} {PubChem} p-Trifluoromethoxyphenylhydrazone, Carbonyl Cyanide {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} para-Trifluoromethoxyphenylhydrazone, Carbonyl Cyanide {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} p-Trifluoromethoxyphenylhydrazone, Carbonyl Cyanide {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {
EC Number206-730-8
Beilstein Registry Number664446
PubChem Substance ID3330
Chemical Name Translation[4-(三氟甲氧基)苯基亚肼基]丙二腈
InChIKeyBMZRVOVNUMQTIN-UHFFFAOYSA-N
Reaxys-RN4693268
InChIInChI=1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H
LabNetwork Molecule IDLN01298846
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分类

  • {SA} Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Organic Covalent Modifiers
  • {SNA} Bioactive Small Molecule Alphabetical Index, C-CH, 一氧化氮和细胞应激, 生物活性小分子, 线粒体抑制剂, 细胞信号转导和神经科学, 细胞应激, 细胞生物学
  • {SNA} Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Mitochondrial Inhibitors, Nitric Oxide and Cell Stress
  • {SNA} Bioactive Small Molecules, C-CH, Cell Signaling and Neuroscience, Cell Stress, Mitochondrial Inhibitors, Nitric Oxide and Cell Stress,

相关文献及参考

  • [2]. Tanpradit N, et al. Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) pre-exposure ensures follicle integrity during in vitro culture of ovarian tissue but not during cryopreservation in the domestic cat model. J Assist Reprod Genet. 2016 Dec;33(12):1621-1631. Epub 2016 Sep 17.
  • [3]. Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2(5):120080.
  • [1]. Connop BP et al.Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J Neurochem. 1999 Apr;72(4):1457-65.
  • [1]. Connop BP et al.Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J Neurochem. 1999 Apr;72(4):1457-65.
  • [2]. Tanpradit N, et al. Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) pre-exposure ensures folli

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H301+H311+H331
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSFG5775000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P316
  • P302+P352
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P333+P313
  • P333+P317
  • P362+P364
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Hazard Class6.1
UN Number 3439
Storage condition N/A℃ No Data Available

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Nitric Oxide and Cell Stress - Cell Signaling and Neuroscience
  5. Cell Stress - Nitric Oxide and Cell Stress
  6. Mitochondrial Inhibitors - Cell Stress
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Organic Covalent Modifiers - Enzyme Inhibitors by Type
  1. Medical Research Areas
  2. Metabolism
  3. Mitochondrial Metabolism  (线粒体代谢)

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