Methyl 2-Amino-3-(4-Chlorophenyl)Propanoate Hydrochloride 4-氯-DL-苯丙氨酸甲酯盐酸盐

CAS 14173-40-1 MFCD00012530

化学结构图

14173-40-1
SMILES: Cl.COC(=O)C(N)CC1C=CC(Cl)=CC=1

化学属性

Mol. FormulaClC6H4CH2CH(NH2)CO2CH3·HCl
Mol. Weight250.12
Melting Point186-189

别名和识别编码

Chemical NameMethyl 2-Amino-3-(4-Chlorophenyl)Propanoate Hydrochloride
MDL NumberMFCD00012530
PubChem Substance ID24278310
CAS Number14173-40-1
EC Number238-024-0
Synonym 4-Chloro-DL-phenylalanine methyl ester hydrochloride; Methyl 4-chloro-3-phenyl-DL-alaninate hydrochloride DL-Pcpa methyl ester hydrochloride 4-氯-DL-苯基丙氨酸甲酯 盐酸盐 DL-Phenylalanine, 4-chloro-, methyl ester, hydrochloride DL-p-Chlorophenylalanine methyl ester hydrochloride DL-3-(p-Chlorophenyl)alanine methyl ester hydrochloride
Chemical Name Translation4-氯-DL-苯丙氨酸甲酯盐酸盐
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分类

  • {SNA} Enzyme Inhibitors, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Tryptophan Hydroxylase, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Tryptophan Hydroxylase

相关文献及参考

  • [2]. Fabio Bellia, et al. Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice. Psychopharmacology (Berl). 2021 Jan;238(1):215-225.
  • [3]. ocío B Foltran, et al. Neurochemical, Behavioral, and Neurogenic Validation of a Hyposerotonergic Animal Model by Voluntary Oral Consumption of para-Chlorophenylalanine. ACS Chem Neurosci. 2020 Mar 18;11(6):952-959.
  • FT-NMR 1 (2), 1228:C / RegBook 1 (2), 1887:B / Sigma FT-IR 1 (1), 115:C / Structure Index 1 , 302:B:6
  • [1]. Dool-Ri Oh, et al. Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABA A-ergic systems: In
  • [1]. Dool-Ri Oh, et al. Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABA A-ergic systems: Involvement of 5-HT 1A receptor agonistic activity. Biomed Pharmacother. 2019 Jan;109:2218-2227.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
GHS Symbol
Precautionary statements
RTECSAY4452100 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 mg/kg
SEX/DURATION            : male 4 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   166,1433,1969

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitter Metabolism - Neurotransmission
  7. Enzyme Inhibitors - Neurotransmitter Metabolism
  8. Tryptophan Hydroxylase - Enzyme Inhibitors
  1. Medical Research Areas
  2. GPCR & G Protein
  3. 5-HT Receptor  (5-羟色胺受体)
  1. Medical Research Areas
  2. Metabolism
  3. Tryptophan Hydroxylase  (色氨酸羟化酶)

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