N-(6-Aminohexyl)-5-Chloronaphthalene-1-Sulfonamide Hydrochloride N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐

CAS 61714-27-0 MFCD00012559

化学结构图

61714-27-0
SMILES: Cl.NCCCCCCNS(=O)(=O)C1C=CC=C2C(Cl)=CC=CC=12

化学属性

Mol. FormulaC16H22Cl2O2N2S
Mol. Weight377
Melting Point220.0 to 224.0 deg-C
TSCANo

别名和识别编码

Chemical NameN-(6-Aminohexyl)-5-Chloronaphthalene-1-Sulfonamide Hydrochloride
CAS Number61714-27-0
Synonym W-7 W-7 hydrochloride N-(6-氨基己基)-5-氯-1-萘磺酰胺 盐酸盐 W7
MDL NumberMFCD00012559
Beilstein Registry Number6030174
PubChem Substance ID135726882
Chemical Name TranslationN-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐
Reaxys-RN6030174
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分类

  • {SNA} Antibiotics, Antibiotics A to Z, Antibiotics A-F, Inhibits an Enzyme, Interferes with Cell Membrane Permeability (Ionophores), Mechanism of Action
  • Inhibitors; Protein Kinase Inhibitors and Activators
  • {SNA} A-AM, Antibiotics A to Z, Antibiotics A-F, Bioactive Small Molecule Alphabetical Index, Calcium Antagonists, Inhibits an Enzyme, Interferes with Cell Membrane Permeability (Ionophores), Intracellular Calcium Signaling, Mechanism of Action, 抗生素, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

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相关文献及参考

  • [2]. M Asano. Divergent Pharmacological Effects of Three Calmodulin Antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), Chlorpromazine and Calmidazolium, on Isometric Tension Development and Myosin Light Chain Phosphorylation in Intact Bovine Tracheal Smooth Muscle. J Pharmacol Exp Ther. 1989 Nov;251(2):764-73.
  • [3]. H Itoh, et al. Direct Interaction of Calmodulin Antagonists With Ca2+/calmodulin-dependent Cyclic Nucleotide Phosphodiesterase. J Biochem. 1984 Dec;96(6):1721-6.
  • [4]. Shigeyuki Yokokura, et al. Calmodulin Antagonists Induce Cell Cycle Arrest and Apoptosis in Vitro and Inhibit Tumor Growth in Vivo in Human Multiple Myeloma. BMC Cancer. 2014 Nov 26;14:882.
  • Hidaka, H., et al.: Proc. Nat. Acad. Sci. USA, 78, 4354 (1981)
  • [1]. H Hidaka,
  • [1]. H Hidaka, et al. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a Calmodulin Antagonist, Inhibits Cell Proliferation. Proc Natl Acad Sci U S A. 1981 Jul;78(7):4354-7.

安全信息

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3
Storage condition <0°C

系列性分类


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