1-Methylguanidine hydrochloride 1-甲基胍盐酸盐

CAS 21770-81-0 MFCD00012576

化学结构图

21770-81-0
SMILES: Cl.CNC(N)=N

化学属性

Mol. FormulaC2H7N3.HCl
Mol. Weight110

别名和识别编码

Chemical Name1-Methylguanidine hydrochloride
CAS Number21770-81-0
Alfabeta NameMETHYLGUANIDINEHYDROCHLORIDE 1-
MDL NumberMFCD00012576
Synonym 1-Methylguanidine hydrochloride 1-甲基胍盐酸盐 甲基胍 盐酸盐 Methylguanidinium Chloride Methylguanidine monohydrochloride N-Methylguanidine monohydrochloride
PubChem Substance ID87572406
EC Number245-147-3
Reaxys-RN3675798
Beilstein Registry Number4(2)571
Chemical Name Translation1-甲基胍盐酸盐
InChIKeyVJQCNCOGZPSOQZ-UHFFFAOYSA-N
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分类

  • Building Blocks, Chemical Synthesis, Guanidines, Nitrogen Compounds, Organic Building Blocks
  • {SNA} Building Blocks, Chemical Synthesis, Guanidines, Nitrogen Compounds, Organic Building Blocks

产品应用

  • N-Methylguanidine is an alkylated guanidine which shows inhibitory action against trypsin catalysis. N-Methylguanidine inhibited metabolism of certain hepatic drugs that was mediated by cytochrome P 4

相关文献及参考

  • Inagami, T. et al.: Biochemistry, 7, 4045 (1968); Hanada, K. et al.: Nephron, 103, 179 (2006);
  • Beil. 4 ,II,571
  • Aldrich MSDS 1 , 1253:D / Corp MSDS 1 (2), 2357:A / FT-IR 2 (1), 1389:B / FT-IR 1 (1), 818:D / FT-NMR 1 (1), 1328:B / IR-Spectra (3), 485:F / NMR-Reference 2 (1), 681:A / RegBook 1 (1), 963:B / Sax 6 , 1856 / Sigma FT-IR 1 (2), 732:C / Structure Index 1 , 149:D:8

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P332+P313
  • P305+P351+P338+P337+P313
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P302+P350
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P305+P351
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Hazard Codes Xn
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning {} {} {} {} {TCI}
RTECSMF3990000
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#04013

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 375 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 28,251,1926

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 680 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CKFRAY Ceskoslovenska Farmacie.  (PNS-Ustredni Expedice a Dovoz Tisku,
   Kafkova 19, 160 00 Prague 6, Czechoslovakia)  V.1-    1952-
   Volume(issue)/page/year: 1,434,1952

系列性分类


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