(R)-(-)-Phenylephrine hydrochloride (R)-(-)-去氧肾上腺素盐酸盐

CAS 61-76-7 MFCD00012605

化学结构图

61-76-7
SMILES:

化学属性

Mol. FormulaC9H13NO2·HCl
Mol. Weight203.67
Melting Point143-145
Solubility>=10 G/100 ML AT 21 ºC
Appearance 白色或类白色结晶性粉末。熔点140-145℃。易溶于水、乙醇,不溶于氯仿、乙醚。左旋游离碱的熔点为169-172℃。
Refractive index-45.5 ° (C=1, H2O)

别名和识别编码

Chemical Name(R)-(-)-Phenylephrine hydrochloride
Synonym 1-m-hydroxy-alpha-(methylaminomethyl)benzylalcoholhydrochloride (R)-PHENYLEPHRINE HYDROCHLORIDE 3-hydroxy-alpha-(methylaminomethyl)benzyl alcohol {Chemic L-PHENYLEPHRINE HCL L(-)-Phenylephrine hydrochloride; (R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride; 3-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol 盐酸L-脱羟肾上腺素 (R)-(-)-去氧肾上腺素 盐酸盐 M-METHYLAMINOETHANOLPHENOL HYDROCHLORIDE (R)-(-)-1-(3-HYDROXYPHENYL)-2-METHYLAMINOETHANOL HYDROCHLORIDE L(-)-PHENYLEPHRINE HYDROCHLORIDE L(-)-Phenylephrine hydrochloride 盐酸脱氧肾上腺素 Adrianol L(-)-PHENYLEPHRINE HCL PHENYLEPHRINE HCL L-1-(M-HYDROXYPHENYL)-2-METHYLAMINOETHANOL HYDROCHLORIDE
MDL NumberMFCD00012605
CAS Number61-76-7
PubChem Substance ID87574605
Beilstein Registry Number4158948
EC Number200-517-3
Reaxys-RN4158948
Merck Number7286
Chemical Name Translation(R)-(-)-去氧肾上腺素盐酸盐
Wiswesser Line NotationQR CYQ1M1 &GH -L
LabNetwork Molecule IDLN00361361
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分类

  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP
  • {SNA} Adrenergics, Adrenergics - Agonists, Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Johnson & Johnson, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, P, Proteins and Derivatives
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards

产品应用

  • 拟肾上腺素药物。对局部身部血管有收缩作用。用于外科物术延长局疗麻醉时间,鼻粘膜充血的消肿消炎等症。

相关文献及参考

  • [2]. Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36.
  • [3]. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13.
  • [4]. Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65.
  • [5]. Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6.
  • Merck: 14,7286
  • Merck: 14,7286 Beilstein: 13,III,2230
  • [1]. Ford AP, et al. P
  • [1]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35.

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P305+P351+P338+P337+P313
  • P301+P312+P330
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSDO7525000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Signal word
Hazard Codes Xn
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Storage condition 储存温度2-8℃
Packing GroupIII
Hazard Class6.1(b)
UN Number 3249
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 89 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 5580

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 86,284,1946

TYPE OF TEST            : LD50 - Lethal dose

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 86,284,1946

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 86,284,1946

TYPE OF TEST            : LD50 - Lethal dose,

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 7 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 368,59,1996

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1500 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-322,1987

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1500 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-322,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 15 mg/kg
SEX/DURATION            : female 22-31 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   SGOBA9 Surgery, Gynecology and Obstetrics.  (Franklin H. Martin Memorial
   Foundation, 55 E. Erie St., Chicago, IL 60611)  V.1-    1905-
   Volume(issue)/page/year: 129,341,1969

其他信息

  • Acros Organics:盐酸苯福林/盐酸去氧肾上腺素 L(-)-Phenylephrine hydrochloride, 99%(61-76-7)
  • MSDS 信息:(R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride(61-76-7).msds
  • 易溶于水、乙醇,不溶于氯仿、乙醚。
  • 比旋光度:-47 ° (c=2, H2O)
  • 上游原料:乙醚 --> 甲苯 --> 苄醇 --> 溴化胺
  • Sigma Aldrich:61-76-7(sigmaaldrich)
  • 图谱信息:盐酸去氧肾上腺素(61-76-7)核磁图( 13 CNMR) 盐酸去氧肾上腺素(61-76-7)Raman光谱 盐酸去氧肾上腺素(61-76-7)红外图谱(IR1) 盐酸去氧肾上腺素(61-76-7)核磁图( 1 HNMR) 盐酸去氧肾上腺素(61-76-7)红外图谱(IR2)
  • 盐酸去氧肾上腺素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P0398 (R)-苯肾上腺素盐酸盐 (R)-Phenylephrine Hydrochloride 25G 926元 2014/06/02 P0398 (R)-苯肾上腺素盐酸盐 (R)-Phenylephrine Hydrochloride 5G 301元 2010/06/21 207240100 盐酸去氧肾上腺素 L(-)-Phenylephrine hydrochloride 99% 10 GR 872元
  • 方法一:间羟基乙酮经苯甲酰化、溴化、胺化、水解、催化氢化,得到间羟基-α-甲氨基甲基苯甲醇(消旋体),再用d-酒石酸拆分,获得左旋游离碱。将游离碱悬浮于无水乙醇中,加氯化氢-乙醇液至pH=4,加热溶解,加活性炭脱色过滤,滤液中加入无水乙醚,冷冻析出结晶。甩滤,结晶用少量丙酮洗涤,干燥,得苯肾上腺素盐酸盐。
  • 用途一:拟肾上腺素药物。对局部身部血管有收缩作用。用于外科物术延长局疗麻醉时间,鼻粘膜充血的消肿消炎等症。
  • 用途二:α1-肾上腺素受体激动剂(α1-adrenoceptor agonist)
  • MOL 文件:61-76-7.mol
  • TCI Shanghai:(R)-苯肾上腺素盐酸盐 (R)-Phenylephrine Hydrochloride,>;98.0%(LC)(T)(61-76-7)

系列性分类


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