Chlorpromazine Hydrochloride,Chlorpromazine Hcl 盐酸氯丙嗪

CAS 69-09-0 MFCD00012654

化学结构图

69-09-0
SMILES: CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21.Cl

化学属性

Mol. FormulaC17H20Cl2N2S
Mol. Weight355
Melting Point195-199
SolubilityDMSO 71 mg/mL Water 71 mg/mL Ethanol 71 mg/mL
TSCAYes
Appearance 白色或乳白色结晶性粉末。熔点179-180℃（194-196℃）。易溶于水、乙醇、氯仿，不溶于乙醚、苯。有引湿性，5%水溶液加pH值为4-5。微臭，味极苦。本品易氧化，在空气或日光中渐变为红棕色。
Stability对光及湿度敏感

别名和识别编码

Chemical NameChlorpromazine Hydrochloride,Chlorpromazine Hcl
CAS Number69-09-0
Alfabeta NameCHLOROPHENOTHIAZINYLPROPYLDIMETHYLAMINEHYDROCHLORIDE H321010[]()-------
MDL NumberMFCD00012654
Synonym Klorproman 2-Chloro-10-[3-(dimethylamino)-1-propyl]phenothiazine hydrochloride 盐酸氯丙嗪 Prom 2-Chloro-10-(3-DimethyAminopropyl)PhenothiazineHydrochloride (3-(2-chloro-phenothiazin-10-yl)-propyl)-dimethyl-amine hydrochloride Plegomazin 2-CHLORO-10-[3'-(DIMETHYLAMINO)PROPYL]PHENOTHIAZINE, HCL 2-氯-10-(3-二甲氨基丙基)吩噻嗪 盐酸盐 10-(3-dimethylaminopropyl)-2-chlorophenothiazine monohydrochloride {Chemica Chlor-PZ Fenactil monohydrochloride KLORPROMEX aminazin hydrochloride Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]-, monohydrochloride 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine Hydrochloride 2-氯-10-(3-二甲氨基丙基)吩噻嗪 盐酸盐 CPZ {Chemi {Ch
Beilstein Registry Number3779989
EC Number200-701-3
PubChem Substance ID6240
Merck Number2185
Reaxys-RN3779989
Chemical Name Translation盐酸氯丙嗪
Wiswesser Line NotationT C666 BN ISJ B3N1&1 EG &GH
LabNetwork Molecule IDLN00159540
InChIInChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
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分类

  • {SNA} Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Calcium Antagonists, Cell Biology, Cell Signaling Enzymes,
  • {SNA} Application Index, Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cell Biology, Cell Signaling Enzymes, Core Bioreagents, Enzyme Inhibitors, Enzymes, Inhibitors, and Substrates, Pharmacopoeia, Pharmacopoeia A-Z, Research Essentials, Substrates, Xenobiotics and Drug Metabolism
  • {S
  • Sulfur & Selenium Compounds
  • {SNA} Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alpha

产品应用

  • 在血红蛋白和过氧化物酶的微量测定中替代联苯胺、邻联?茴香胺和邻联甲苯胺。

相关文献及参考

  • Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970),
  • Short: III/5b Title: Structure Data of Organic Crystals: C 14 ... C 120 Author: Schudt, E.; Weitz, G. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/5b Year: 1971 ISBN: 3-540-05177-5 ISBN: 978-3-540-05177-0 Internet Resource: DOI:10.1007/b19970 RefComment: XXI, 736 pages, and VII, 890 pages. Hardcover Abstract: Volume III/5 offers a compitation as complete as possible of the space groups and lattice con-stants of all crystals which have been studied by means of X-rays, neutron and electron diffraction.
  • Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Precautionary statements
  • P301+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310+P330
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P304+P340+P310
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P405 Store locked up. 上锁保管。
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H330 Fatal if inhaled 吸入致命
RTECSSO1750000
Signal word
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Packing GroupI
UN Number UN 2811 6.1/PG 1
Risk Statements
Hazard Codes T+
Hazard Class6.1
Storage condition 室温保存 储存温度-20°C 储存温度 -20°C 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,1106,1986

TYPE OF TEST            : LC50 -

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 62 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSYPAG Psychopharmacologia (Berlin).  (Berlin, Ger.)  V.1-46, 1959-76.  For
   publisher information, see PSCHDL.  Volume(issue)/page/year: 12,142,1968

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >30 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 122,129,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 6 mg/kg
TOXIC EFFECTS :
   Behavioral - anorexia (human)
   Gastrointestinal - other changes
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 60,564,1984

TYPE OF TEST

{hazard_co

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 208,33,1988

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 mg/L
REFERENCE :
   GENRA8 Genetical Research.  (Cambridge Univ. Press, 32 E. 57th St., New
   York, NY 10022) V.1-    1960-  Volume(issue)/page/year: 30,13,1977

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 48 mg/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   26,1205,1977

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 25 mg/kg
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 9,41,1986

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 48 mg/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   26,1205,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 18,167,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 7-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,230,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 12 mg/kg
SEX/DURATION            : female 12-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   BRREAP Brain Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1966-  Volume(issue)/page/year: 21,460,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 125 mg/kg
SEX/DURATION            : male 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (B

其他信息

  • 类别:有毒物质
  • 方法一:由2-氯吩噻嗪[92-39-7]缩合、成盐而得。1.缩合在反应锅中加入2-氯吩噻嗪和甲苯，再加入氢氧化钠，搅拌加热回流，脱除水分，在110℃滴加1-氯-3-二甲胺基丙烷的甲苯溶液，将反应物减压回收甲苯，即得氯丙嗪，C17H19CIN2S，[50-53-3]。2.成盐 将氯丙嗪和异丙醇搅拌加热至40℃，通入干燥的氯化氢至pH4-5，即成盐得到盐酸氯丙嗪。
  • 氯丙嗪 盐酸盐
  • 毒性分级:高毒
  • MOL 文件:69-09-0.mol
  • 上游原料:二甲胺 --> 1-溴-3-氯丙烷 --> 2-氯吩噻嗪
  • 可燃性危险特性:可燃, 燃烧时分解有毒氮氧化物, 氯化物, 硫氧化物气体
  • 急性毒性:口服- 大鼠 LD50 145 毫克/ 公斤; 口服- 小鼠 LD50: 135 毫克/公斤
  • 用途一:本品是吩噻类药物中的代表性药物。对中枢神经系统，小剂量有安定作用，大剂量连续使用有抗精神病作用，本品抑制丘脑下体温调节中枢，使体温随环境温度升降，配合其他药物，使体温降至正常体温之下，代谢降低，称人工冬眠。主要用于抗精神病、加强催眠剂、麻醉剂、镇痛剂及抗惊厥剂的作用。又可用于对呕吐和顽固性呃逆的镇吐及引起人工冬眠等。
  • 储运特性:库房低温, 通风, 干燥; 与食品原料分开存放
  • 灭火剂:水, 二氧化碳, 干粉, 砂土
  • F:3-10-21
  • MSDS 信息:Largactil(69-09-0).msds
  • 海关编码:29173980
  • Sigma Aldrich:69-09-0(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. C-CH - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Intracellular Calcium Signaling - Cell Signaling and Neuroscience
  5. Calcium Antagonists - Intracellular Calcium Signaling
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Substrate Analogs - Enzyme Inhibitors by Type

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