Hoechst 33258 Trihydrochloride 4-(5-[5-(4-甲基-1-哌嗪基)-2H-苯并咪唑-2-亚基]-5H-苯并咪唑-2-基)苯酚三盐酸盐

CAS 23491-45-4 MFCD00012679

化学结构图

23491-45-4
SMILES: Cl.Cl.Cl.CN1CCN(CC1)C1=CC2N=C(NC=2C=C1)C1=CC2N=C(NC=2C=C1)C1C=CC(O)=CC=1

化学属性

Mol. FormulaC25H27Cl3N6O
Mol. Weight534
Melting Point314 ºC
Solubility可溶

别名和识别编码

Chemical NameHoechst 33258 Trihydrochloride
Synonym Hoechst Dye 33258 Bisbenzimide Hoechst 33258 HOE 33058 NSC334072 甲嗪双苯咪酚 三盐酸盐 H 33258 赫斯特荧光染料 33258 溶液 BXI-72 Hoechst 33258 溶液 烟酸己可碱 三盐酸盐 Bisbenzimidazole trihydrochloride Bisbenzimide H 33258 NSC-322921 赫斯特荧光染料 33258 33258 Hoechst BBIH Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, Hoechst Stain solution Bisbenzimide; p-(5-(5-(4-Methyl-1-piperazinyl)-1H-2-benzimidazolyl)-1H-2-benzimidazolyl)phenol trihydrochloride BBIH BXI-72 HOE 33258 Hoechst 33258 NSC334072 烟酸己可碱 三盐酸盐 甲嗪双苯咪酚 三盐酸盐 HOE 33258
CAS Number23491-45-4
PubChem Substance ID172089156
EC Number245-690-6
Beilstein Registry Number4088183
MDL NumberMFCD00012679
Chemical Name Translation4-(5-[5-(4-甲基-1-哌嗪基)-2H-苯并咪唑-2-亚基]-5H-苯并咪唑-2-基)苯酚三盐酸盐
Reaxys-RN4088183
Wiswesser Line NotationT56 BM DNJ CR DQ& G- CT56 BM DNJ G- AT6N DNTJ D1 &GH3
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分类

  • {SNA} Alphabetical, Apoptosis Detection, Apoptosis and Cell Cycle, B, Bioactive Small Molecule Alphabetical Index, Fluorescent Stains, Mycoplasma Detection, Nucleic Acid Stains, Reagents, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞培养, 细胞生物学, 荧光探针,标记,粒子和染色剂, 试剂和添加剂
  • In Vivo/In Vitro Tracking of Stem
  • {SNA} Alphabetical, Detection, Fluorescent Stains, Nucleic Acid Stains, Nucleic Acid Stains For Flow Cytometry, Nucleic Acid Stains For Microscopy, Wavelength Index, 发光化合物及其检测,

相关文献及参考

  • {
  • Merck 14 ,10367

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xn
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSSM1140500
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P302+P352+P332+P313+P362+P364
  • P332+P313
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P302+P350
  • P337+P313
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
Risk Statements
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Storage condition <0°C
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 36900 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB84-171206

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 32200 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB84-171206

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 1600 nmol/L
REFERENCE :
   CHROAU Chromosoma.  (Springer-Verlag New York, Inc., Service Center, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-    1939-  Volume(issue)/page/year:
   52,297,1975

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - rat Fibroblast
DOSE/DURATION           : 1 mg/L
REFERENCE :
   ZZACAG Zeitschrift fuer Zellforschung und Mikroskopische Anatomie. (Berlin,
   Fed. Rep. Ger.) V.1-147, 1924-73.  For publisher information, see CTSRCS. 
   Volume(issue)/page/year: 104,127,1970

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 2 umol/L
REFERENCE :
   CHROAU Chromosoma.  (Springer-Verlag New York, Inc., Service Center, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-    1939-  Volume(issue)/page/year:
   52,297,1975

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 1 mg/L
REFERENCE :
   ZZACAG Zeitschrift fuer Zellforschung und Mikroskopische Anatomie. (Berlin,
   Fed. Rep. Ger.) V.1-147, 1924-73.  For publisher information, see CTSRCS. 
   Volume(issue)/page/year: 104,127,1970

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 umol/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 258,121

系列性分类


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