4-(2-Chloroethyl)morpholine hydrochloride N-(2-氯乙基)吗啉盐酸盐

CAS 3647-69-6 MFCD00012797

化学结构图

3647-69-6
SMILES: Cl.ClCCN1CCOCC1

化学属性

Mol. FormulaC6H13Cl2NO
Mol. Weight186.08
Melting Point180-185°C
TSCAYes
Solubility可溶
Appearance 类白色结晶粉末,熔点184-186℃。

别名和识别编码

Chemical Name4-(2-Chloroethyl)morpholine hydrochloride
Synonym 4-(2-Chloroethyl)morpholine hydrochloride {LY} 4-(2-Chloroethyl)morpholine hydrochloride {} {LY} 4-(2-Chloroethyl)morpholine hydrochloride {} {} {LY} 4-(2-Chloroethyl)morpholine hydrochloride {} {} {} {LY} 4-(2-Chloroethyl)morpholine hydrochloride {} {} {} {} {LY} 4-(2-Chloroethyl)morpholine hydrochloride {} {} {} {} {} {LY} 4-(2-Chloroethyl)morpholine hydrochloride {} {} {} {} {} {} {LY} 4-(2-Chloroethyl)morpholine hydrochloride {} {} {} {} {} {} {} {LY} 4-(2-Chloroethyl)morpholine hydrochloride {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} 4-(2-Chloroethyl)morpholine hydrochloride {} {} {} {} {} {} {} {} {} {LY} 4-(2-Chloroethyl)morpholine hydrochloride {} {} {} {} {} {} {} {} {} {} {LY} 4-(2-Chloroethyl)morpholine hydrochloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-(2-Chloroethyl)morpholine hydrochloride {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-(2-Chloroethyl)morpholine hydrochloride {} {} {} {} {} {} {} {} {} {} {
CAS Number3647-69-6
PubChem Substance ID77210
EC Number222-881-2
Beilstein Registry Number3684083
MDL NumberMFCD00012797
Reaxys-RN3684083
Chemical Name TranslationN-(2-氯乙基)吗啉盐酸盐
InChIKeyNBJHDLKSWUDGJG-UHFFFAOYSA-N
Wiswesser Line NotationT6N DOTJ A2G &GH
LabNetwork Molecule IDLN00008816
InChIInChI=1S/C6H12ClNO.ClH/c7-1-2-8-3-5-9-6-4-8;/h1-6H2;1H
Canonical SMILESClCCN1CCOCC1.[H]Cl
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分类

  • Building Blocks, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Morpholines/Thiomorpholines
  • {SNA} Building Blocks, C4 to C10, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Morpholines/Thiomorpholines

相关文献及参考

  • Beil. 27 ,IV,24
  • FT-IR 1 (1), 383:C / FT-IR 2 (1), 597:A / IR-Spectra (3), 226:H / IR-Spectra (2), 203:C / NMR-Reference 2 (1), 336:D / RegBook 1 (1), 403:F / Sax 6 , 719 / Structure Index 1 , 58:A:4

安全信息

GHS Symbol
WGK Germany2
Hazard Codes 8 T
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H312 Harmful in contact with skin 皮肤接触有害
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSQE0260000
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 2923
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R21 Harmful in contact with skin 与皮肤接触有害
  • R25 Toxic if swallowed 吞咽有毒
  • R34 Causes burns 会导致灼伤
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture Hygroscopic {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away f
Packing GroupIII
Hazard Class8/6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 161 mg/kg
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 2,1075,1949

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 44 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,33,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 21500 nmol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,11,1981

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,11,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 21500 nmol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,11,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 150 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 2,1075,1949

其他信息

  • MSDS 信息:2-Morpholinoethyl chloride hydrochloride(3647-69-6).msds
  • 可燃性危险特性:可燃, 火场释放有毒氯化物, 氮氧化物烟雾
  • 用途一:医药中间体。
  • 毒性分级:中毒
  • 储运特性:库房低温通风干燥
  • 爆炸物危险特性:0
  • 刺激数据:0
  • 图谱信息:N-(2-氯乙基)吗啉盐酸盐(3647-69-6)质谱(MS) N-(2-氯乙基)吗啉盐酸盐(3647-69-6)红外图谱(IR1) N-(2-氯乙基)吗啉盐酸盐(3647-69-6)核磁图( 1 HNMR) N-(2-氯乙基)吗啉盐酸盐(3647-69-6)红外图谱(IR2)
  • 急性毒性:腹腔-小鼠 LD50: 161 毫克/公斤
  • 敏感性:Hygroscopic
  • 方法一:吗啉与环氧乙烷加成制得吗啉乙醇,再与氯化亚砜进行氯化反应得到氯化乙基吗啉盐酸盐。
  • 上游原料:2-吗啉乙醇
  • 职业标准:0
  • 类别:有毒物质
  • Sigma Aldrich:3647-69-6(sigmaaldrich)
  • Alfa Aesar:4-(2-氯乙基)吗啉盐酸盐,99% 4-(2-Chloroethyl)morpholine hydrochloride, 99%(3647-69-6)
  • N-(2-氯乙基)吗啉盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C1106 N-(2-氯乙基)吗啉盐酸盐 4-(2-Chloroethyl)morpholine Hydrochloride 25G 156元 2014/06/02 C1106 N-(2-氯乙基)吗啉盐酸盐 4-(2-Chloroethyl)morpholine Hydrochloride 500G 1360元 2010/06/21 109200050 N-(2-氯乙基)吗啉盐酸盐 N-(2-Chloroethyl)morpholine hydrochloride 99% 5 GR 230元
  • TCI Shanghai:N-(2-氯乙基)吗啉盐酸盐 4-(2-Chloroethyl)morpholine Hydrochloride,>;97.0%(T)(3647-69-6)
  • MOL 文件:3647-69-6.mol
  • Acros Organics:N-(2-氯乙基)吗啉盐酸盐 N-(2-Chloroethyl)morpholine hydrochloride, 99%(3647-69-6)
  • 下游产品:4-(2-吗啉-4-基-乙氧基)苯甲酸
  • 灭火剂:水, 二氧化碳, 泡沫, 沙土
  • 海关编码:29349990

系列性分类