Pyridine Hydrochloride 吡啶盐酸盐

CAS 628-13-7 MFCD00012802

化学结构图

628-13-7
SMILES: Cl.c1ccncc1

化学属性

Mol. FormulaC5H6ClN
Mol. Weight115.56
Density1.0
Boiling Point222-224 °C at 760 mmHg
Melting Point145-147 °C
TSCAYes
Solubility85 G/100 ML
Stability易吸潮
Flash Point222-224°C

别名和识别编码

Chemical NamePyridine Hydrochloride
CAS Number628-13-7
Synonym Pyridine (hydrochloride) {LY} Pyridine (hydrochloride) {} {LY} Pyridine (hydrochloride) {} {} {LY} Pyridine (hydrochloride) {} {} {} {LY} Pyridine (hydrochloride) {} {} {} {} {LY} Pyridine (hydrochloride) {} {} {} {} {} {LY} Pyridine (hydrochloride) {} {} {} {} {} {} {LY} Pyridine (hydrochloride) {} {} {} {} {} {} {} {LY} Pyridine (hydrochloride) {} {} {} {} {} {} {} {} {LY} Pyridine (hydrochloride) {} {} {} {} {} {} {} {} {} {LY} Pyridine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {LY} Pyridine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridine (hydrochloride) {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00012802
EC Number211-027-4
Beilstein Registry Number3615340
PubChem Substance ID87557963
Reaxys-RN3615340
Chemical Name Translation吡啶盐酸盐
Wiswesser Line NotationT6NJ &GH
LabNetwork Molecule IDLN02210656
Canonical SMILESCl.N1=CC=CC=C1
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分类

  • {uni_hamburg} no charge; nitrogen heterocycle; 6RingOnly; 6ring; 2fragments; ionic
  • Heterocycles
  • Miscellaneous Reagents
  • Intermediates
  • Aromatics
  • {SNA} Building Blocks, C5, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines

产品应用

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相关文献及参考

  • {
  • Demethylation of methyl aryl ethers can also be carried out under solvent-free conditions with microwave irradiation: J. Chem. Res. (Synop.), 394 (1999).
  • Short: III/20a
  • Short: IV/1a
  • Cleaves N-trityl groups from histidine residues in peptide synthesis: Tetrahedron Lett., 28, 6031 (1987).
  • Mild acid catalyst, e.g. in the formation of acetals with ethylene glycol: J. Org. Chem., 31, 26 (1966), or 1,3-propanediol: Bull. Soc. Chim. Fr., 2287 (1972); and in the Fischer indole synthesis for acid-sensitive substrates: Synthesis, 645 (1977).
  • Epoxides at ambient temperature in chloroform give chlorohydrins: Synth. Commun., 11, 287 (1981).
  • Beilstein:20(5)5,160
  • Egyed, J. et al.: Bull. Soc. Chim. Fra., 11, 3014 (1973); Li, Y. et al.: Wuli HUa. Xueb., 14, 1048 (1998);
  • In DMF, has been used for the conversion of alkyl tosylates to chlorides at room temperature: J. Am. Chem. Soc., 80, 2726 (1958).
  • Classical reagent for cleavage of aryl methyl ethers at 200-220 o : Ber ., 75, 445 (1942), avoiding the strongly acidic or basic conditions of some alternative methods; see, e.g.: J. Org. Chem., 27, 4660 (1962):
  • Short: II/2

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302+H332
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSUT4375000
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage,
Hazard Codes Xn
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KODAK* Kodak Company Reports.  (343 State St., Rochester, NY 14650)
   Volume(issue)/page/year: 21MAY1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2500 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KODAK* Kodak Company Reports.  (343 State St., Rochester, NY 14650)
   Volume(issue)/page/year: 21MAY1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KODAK* Kodak Company Reports.  (343 State St., Rochester, NY 14650)
   Volume(issue)/page/year: 21MAY1971

其他信息

  • MOL 文件:628-13-7.mol
  • Sigma Aldrich:628-13-7(sigmaaldrich)
  • MSDS 信息:Pyridine hydrochloride(628-13-7).msds
  • F:3-10
  • 遇空气极易吸湿并呈水样,有吡啶臭味。水中溶解度: 85G/100G水
  • TCI Shanghai:吡啶盐酸盐 Pyridine Hydrochloride,>;98.0%(T)(628-13-7)
  • Acros Organics:吡啶盐酸盐 Pyridine hydrochloride, pure, 98%(628-13-7)
  • 用途一:用作医药中间体
  • 吡啶盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30160224 吡啶盐酸盐;盐酸吡啶 25g 63元 2011/04/16 P1637 吡啶盐酸盐 Pyridine Hydrochloride 500G 1190元 2011/04/16 P1637 吡啶盐酸盐 Pyridine Hydrochloride 25G 196元
  • 外观性质:白色结晶性粉末,遇空气极易吸湿并呈水样,有吡啶臭味。水中溶解度: 85G/100G水沸点:222-224℃熔点:147℃
  • Alfa Aesar:嘧啶盐酸盐,98% Pyridine hydrochloride, 98%(628-13-7)
  • 海关编码:29333100
  • 下游产品:西伯尔链接剂
  • 敏感性:Hygroscopic

系列性分类


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