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• 试剂商城
• 直接询价

分类

• {SNA} Building Blocks, C6, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines
• {SNA} Building Blocks, C6, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyridines

相关文献及参考

• Beilstein: 20,V,5,498
• For a study of the base-catalyzed alkylation of p-t-butylcalix[5]arene, see: J. Org. Chem., 61, 2407 (1996).
• The free base has also been used for the protection of OH groups as 2-picolyl derivatives, relatively stable to acid (HF, TFA) but selectively cleaved by electrolytic reduction: Acta Chem. Scand. B, B37, 475 (1983); J. Chem. Res. (Synop.), 22 (1977).
• The free base, generated from the hydrochloride with aqueous OH-, can be metallated (LDA, -78o) at the methylene group. Subsequent reaction with a ketone provides a route to otherwise inaccessible pyridyloxiranes: Tetrahedron Lett., 35, 3175 (1994). Similarly, reaction of the lithio derivative with an imine gives a pyridylaziridine, generally in good yield: J. Org. Chem., 60, 2279 (1995).

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 316 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to
   the National Cancer Institute by Litton Bionetics, Inc.  (Bethesda, MD)
   Volume(issue)/page/year: NCI-E-C-72-3252,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 316 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to
   the National Cancer Institute by Litton Bionetics, Inc.  (Bethesda, MD)
   Volume(issue)/page/year: NCI-E-C-72-3252,1973

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 95250 nmol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   19,98,1992

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   NTPTB* NTP Technical Bulletin.  (National Toxicology Program, Landow Bldg.
   3A-06, 7910 Woodmont Ave., Bethesda, MD 20205)  Volume(issue)/page/year:
   APR1982

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 341,161,1995

其他信息

• MSDS 信息:2-(Chloromethyl)pyridine hydrochloride(6959-47-3).msds
• F:3-10
• 2-氯甲基吡啶盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 172120050 2-氯甲基吡啶盐酸盐 2-Picolyl chloride hydrochloride 98% 5 GR 317元 2010/06/21 172120250 2-氯甲基吡啶盐酸盐 2-Picolyl chloride hydrochloride 98% 25 GR 1001元 2010/06/21 172121000 2-氯甲基吡啶盐酸盐 2-Picolyl chloride hydrochloride 98% 100 GR 2685元
• 用途二:2-氯甲基吡啶是植物生长调节剂吡啶醇的中间体，也是医药扑尔敏的中间体。
• Acros Organics:2-(氯甲基)吡啶盐酸盐 2-Picolyl chloride hydrochloride, 98%(6959-47-3)
• MOL 文件:6959-47-3.mol
• 下游产品:二甲基吡啶胺
• 上游原料:碳酸钠 --> 2-甲基吡啶
• 检测方法:T,NMR
• 图谱信息:2-氯甲基吡啶盐酸盐(6959-47-3)红外图谱(IR1) 2-氯甲基吡啶盐酸盐(6959-47-3)红外图谱(IR2) 2-氯甲基吡啶盐酸盐(6959-47-3)质谱(MS) 2-氯甲基吡啶盐酸盐(6959-47-3)核磁图( 13 CNMR)
• TCI Shanghai:2-(氯甲基)吡啶盐酸盐 2-(Chloromethyl)pyridine Hydrochloride,>;98.0%(T)(6959-47-3)
• 水中溶解度：≥10 g/100 mL
• 敏感性:Hygroscopic
• Sigma Aldrich:6959-47-3(sigmaaldrich)
• 用途一:用作医药中间体
• Alfa Aesar:2-氯甲基吡啶盐酸盐,98% 2-(Chloromethyl)pyridine hydrochloride, 98%(6959-47-3)
• Hazard Note:Corrosive
• 方法一:其制备方法是将2-甲基吡啶及四氯化碳混合后，加入无水碳酸钠，加热，当升温至58～60℃时，在光照射下开始通氯气，温度保持在60～65℃，由气相色谱控制反应终点，经脱溶再蒸馏，与盐酸成盐得到产品。