6-Hydroxydopaminehydrochloride 6-羟基多巴胺盐酸盐
CAS 28094-15-7 MFCD00012895
化学结构图
SMILES: Cl.NCCC1=CC(O)=C(O)C=C1O
化学属性
| Mol. Formula | (HO)3C6H2CH2CH2NH2· HCl |
|---|---|
| Mol. Weight | 205.64 |
| Melting Point | 232-233 °C (dec.)(lit.) |
别名和识别编码
| Chemical Name | 6-Hydroxydopaminehydrochloride |
|---|---|
| CAS Number | 28094-15-7 |
| Synonym | 2,4,5-Trihydroxyphenethylamine Hydrochloride 2,4,5-Trihydroxyphenethylamine hydrochloride 2,4,5-Trihydroxyphenethylamine hydrochloride 2,5-Dihydroxytyramine hydrochloride 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride 6-OHDA 5-(2-Aminoethyl)-1,2,4-benzenetriol Hydrochloride 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrochloride 6-Hydroxydopamine Hydrochloride 6-Hydroxydopamine chloride 6-Hydroxydopamine hydrochloride Oxidopamine Hydrochloride Topamine Hydrochloride |
| MDL Number | MFCD00012895 |
| Beilstein Registry Number | 4274007 |
| EC Number | 248-837-2 |
| PubChem Substance ID | 24895641 |
| Wiswesser Line Notation | Z2R BQ CQ DQ &GH |
| Chemical Name Translation | 6-羟基多巴胺盐酸盐 |
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分类
- Neurochemicals
- Pharmaceuticals
- {SNA} Adrenergics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, H, Neuroscience, Neurotransmission, Neurotransmitters, Others
- Intermediates & Fine Chemicals
- {SNA} Adrenergics, Bioactive Small Molecule Alphabetical Index, H, Neuroscience, Neurotransmission, Neurotransmitters, Others, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Amines
- {SNA} Adrenergics, Bioactive Small Molecule Alphabetical Index, H, Neuroscience, Neurotransmission, Neurotransmitters, Other
产品应用
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相关文献及参考
- [2]. Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000 Apr;74(4):1605-12.
- Soto-Otero, R. et al.: J. Neurochem., 74, 1605 (2000); Fujita, H. et al.: Brain Res., 1113, 10 (2006); Breese, G.R. et al.: 174, 313 (1970);
- [1]. Fujita H et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23.
- [1]. Fujita H et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23.
- [2]. Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg/52W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application REFERENCE : RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 17,411,1977
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