Cysteamine Hydrochloride 半胱胺盐酸盐(2-氨基乙硫醇盐酸盐)

CAS 156-57-0 MFCD00012904

化学结构图

156-57-0
SMILES: Cl.NCCS

化学属性

Mol. FormulaC2H8ClNS
Mol. Weight113.61
Melting Point67-71 °C
Density1.422
SolubilitySoluble in water and alcohol
TSCAYes
Stability易吸潮
Appearance (大鼠，腹腔) 231.9 mg/kg。 白色结晶状物质；有特殊气味；易潮解，易溶于水和乙醇；对光不稳定，水溶液易氧化为胱氨，有时产生沉淀；mp为71℃；LD 50
Boiling Point238.5 °C at 760 mmHg

别名和识别编码

Chemical Name2-Aminoethanethiol Hydrochloride
CAS Number156-57-0
Synonym Cysteamine (hydrochloride) {LY} Cysteamine (hydrochloride) Cysteamine Bitartrate Cysteamine Dihydrochloride Cysteamine Hydrobromide Cysteamine Hydrochloride Cysteamine Maleate (1:1) Cysteamine Tartrate Cysteamine Tartrate (1:1) Cysteamine Tosylate Cysteamine, 35S Labeled Cysteamine, 35S-Labeled Cysteinamine Dihydrochloride, Cysteamine Hydrobromide, Cysteamine Hydrochloride, Cysteamine Mercamine Mercaptamine Mercaptoethylamine Tartrate, Cysteamine Tosylate, Cysteamine beta Mercaptoethylamine beta-Mercaptoethylamine {} {LY} Cysteamine (hydrochloride) {} {} {LY} Cysteamine (hydrochloride) {} {} {} {LY} Cysteamine (hydrochloride) {} {} {} {} {LY} Cysteamine (hydrochloride) {} {} {} {} {} {LY} Cysteamine (hydrochloride) {} {} {} {} {} {} {} {} {} {}
Beilstein Registry Number3590083
EC Number205-858-1
MDL NumberMFCD00012904
Reaxys-RN3590083
PubChem Substance ID9082
Merck Number2779
Chemical Name Translation半胱胺盐酸盐(2-氨基乙硫醇盐酸盐)
Wiswesser Line NotationZ2SH &GH
LabNetwork Molecule IDLN00008519
InChIInChI=1S/C2H7NS.ClH/c3-1-2-4;/h4H,1-3H2;1H
Canonical SMILESSCCN.Cl
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分类

  • {SNA} A to C, Aminopeptidase, Biochemicals and Reagents, Denaturation, Disulfide Bridge Cleavage Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Molecular Biology, Protease Inhibitor Specificity Index, Protease Inhibitors, Protein Modification,

产品应用

  • 是制造西咪替丁、雷尼替丁等药物的中间体。生化试剂，重金属离子的络合剂等。

相关文献及参考

  • [2]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6.
  • For selective protection of nitrogen by silylation, see: Synthesis, 924 (1980).
  • Merck:14,2779
  • Merck:14,2779 Beilstein:4,286
  • Short: EINECS
  • Short: III/10a
  • [1]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92.
  • [1]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92.
  • [2]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6.

安全信息

GHS Symbol
WGK Germany3
Signal word Warning
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes 9
RTECSKJ0200000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P301+P317
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P313 Get medical advice/attention. 获取医疗咨询/就医
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P333+P313
  • P333+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition 2-8°C, protect from light, stored under nitrogen {LY} 2-8°C, protect from light, stored under nitrogen Hygroscopic {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Packing GroupIII
UN Number 3335 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 244 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   14,132,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 12,510,1969

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ABPAAG Acta Biologiae Experimentalis (Warszawa).  (Nencki Institute of
   Experimental Biology) V.1-13, 1928-39; V.14-29, 1947-69.
   Volume(issue)/page/year: 12,142,1938

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1352 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 20,721,1972

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 334,317,1995

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 5 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 153,57,1985

其他信息

  • 用途二:用于生化研究，放射病的预防和治疗。
  • Sigma Aldrich:156-57-0(sigmaaldrich)
  • Alfa Aesar:2-巯基乙胺盐酸盐,98+% 2-Mercaptoethylamine hydrochloride, 98+%(156-57-0)
  • 半胱胺盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 62007080 盐酸半胱胺 5g 120元 2011/04/16 A0296 2-氨基乙硫醇盐酸盐 2-Aminoethanethiol Hydrochloride 25G 360元 2011/04/16 A0296 2-氨基乙硫醇盐酸盐 2-Aminoethanethiol Hydrochloride 500G 3680元
  • Acros Organics:2-巯基乙胺盐酸盐 2-Aminoethanethiol hydrochloride, 98%(156-57-0)
  • 海关编码:29309070
  • 用途四:是制造西咪替丁、雷尼替丁等药物的中间体。生化试剂，重金属离子的络合剂等。
  • 上游原料:盐酸 --> 硫酸 --> 二硫化碳 --> 乙醇胺
  • 下游产品:1,3-噻唑烷-2-酮 --> 四氢噻唑
  • F:1-3-10-13
  • MOL 文件:156-57-0.mol
  • 敏感性:Hygroscopic
  • 用途一:是制造西咪替丁、雷尼替丁等药物的中间体
  • 参考质量标准:含量不少于96%；mp为66-69℃；水溶性试验、炽灼残杂等项均合格。
  • 方法一:以2-氨基乙醇为原料，经氢溴酸溴化，再于硫酸、二硫化碳反应环合，最后盐酸水解而得。
  • TCI Shanghai:2-氨基乙硫醇盐酸盐 2-Aminoethanethiol Hydrochloride,>;95.0%(T)(156-57-0)
  • 用途三:雷尼替丁、西米替丁的中间体，也可作扑热息痛中毒的解毒剂。
  • MSDS 信息:Cysteamine hydrochloride(156-57-0).msds
  • 图谱信息:半胱胺盐酸盐(156-57-0)红外图谱(IR1) 半胱胺盐酸盐(156-57-0)核磁图( 13 CNMR) 半胱胺盐酸盐(156-57-0)红外图谱(IR2) 半胱胺盐酸盐(156-57-0)红外图谱(IR3)
  • 非易燃易爆品，比重为1.3-1.4，稍有臭味，易潮解，遇铁显绿色，能与许多有机物起缩合反应，是许多金属离子的铬合剂。

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Denaturation - Biochemicals and Reagents
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Denaturation - Biochemicals and Reagents
  4. Alphabetical - Denaturation
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Denaturation - Biochemicals and Reagents
  4. Disulfide Bridge Cleavage Reagents - Denaturation
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Thiols/Mercaptans - Sulfur Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Thiol/Mercaptan Salts - Sulfur Compounds
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Aminopeptidase - A to C
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Thiol Esters
  1. Functional Group 官能团索引
  2. alkylthiol
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Denaturation
  4. Acids and Bases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Denaturation
  4. Detergents
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Ribonuclease A
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Spermidine synthase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Alkaline Phosphatase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteomics
  4. Protein Structural Analysis
  5. Protein Modification
  6. Reduction and Oxidation
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Serine Protease Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Proteolytic Enzymes and Substrates
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Serine Protease Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Signal Transduction Research Tools
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Serine Protease Inhibitors
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)