Semicarbazide hydrochloride 盐酸氨基脲

CAS 563-41-7 MFCD00013009

化学结构图

563-41-7
SMILES: Cl.NNC(N)=O

化学属性

Mol. FormulaCH6ClN3O
Mol. Weight111.53
Melting Point175-177°C
TSCAYes
Density1.286
Solubility100 G/L (15 ºC)
Stability对湿度敏感
Appearance 无色透明或白色结晶。 溶于水，不溶于无水乙醇和乙醚。
Boiling Point394.09 °C at 760 mmHg

别名和识别编码

Chemical NameSemicarbazide hydrochloride
CAS Number563-41-7
Synonym Semicarbazide (hydrochloride) {LY} Semicarbazide (hydrochloride) {} {LY} Semicarbazide (hydrochloride) {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydroc
Beilstein Registry Number3,98
PubChem Substance ID11236
EC Number209-247-0
MDL NumberMFCD00013009
Reaxys-RN3593642
Merck Number8444
Chemical Name Translation盐酸氨基脲
Wiswesser Line NotationZVMZ &GH
LabNetwork Molecule IDLN00197635
InChIInChI=1S/CH5N3O.ClH/c2-1(5)4-3;/h3H2,(H3,2,4,5);1H
Canonical SMILESNNC(N)=O.[H]Cl
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分类

  • Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks, Ureas
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standard, Analytical Standards, Analytical/Chromatography, Applications, Food & Beverage Analysis, Processing/Packaging Contaminants, S, SA - SM, Semicarbazide
  • {SNA} Building Blocks, Carbonyl Compounds, Chemical Synth
  • {SNA} Analytical Standard, Analytical Standards, Antibiotics Standards, Pharmaceuticals, Illicit Drugs & Alcohol, Processing/Packaging Contaminants, Semicarbazide, 分析/色谱, 应用, 食品和饮料分析

产品应用

  • 测定酮、醛的试剂、色谱分析试剂及分离激素和精油的溶剂。脲酶底物，MAO抑制剂。

相关文献及参考

  • Merck:14,8444
  • Other reagents for the cleavage of semicarbazones include: Amberlyst. 15 in aqueous acetone: J .Chem. Soc., Perkin 1, 2563 (1988); Dowex. 50 in aqueous suspension: J. Org. Chem., 53, 878 (1988); CuSO4 in aqueous THF: J. Prakt. Chem., 322 1063 (1980).
  • Merck:14,8444 Beilstein:3,98
  • Elliott, J., et al.: J. Pharm. Pharmacol., 41, 37 (1989),
  • Tribalat, L., et al.: Anal. Bioanal. Chem., 386, 2168 (2006),
  • Derivatizing agent for carbonyl compounds as their semicarbazones. Also used in heterocyclic synthesis. Semicarbazone formation has been used to separate carbonyl compounds from mixtures by adsorption onto silica gel from a hydrocarbon solution. Regeneration is by hydrolysis with oxalic acid: Tetrahedron, 37, 843 (1981).

安全信息

Precautionary statements
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P332+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P310
  • P302+P350
  • P308+P313
  • P302+P352+P332+P313+P362+P364
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
RTECSVT3500000
GHS Symbol
Signal word
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Hazard Codes T
WGK Germany3
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
UN Number UN 2811 6.1/PG 3 2811
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Packing GroupIII
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage,
Hazard Class6.1 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 67 gm/kg/76W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Vascular - tumors
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 11,17,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 167 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   21,635,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 24,623,1961

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 24,623,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 10,686,1960

T

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - grasshopper
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 40,237,1976

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - grasshopper
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 40,237,1976

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - grasshopper
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 40,237,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 100 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ACATA5 Acta Anatomica.  (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY
   10003)  V.1-    1945-  Volume(issue)/page/year: 100,347,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 550 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   BNEOBV Biology of the Neonate.  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.15-    1970-  Volume(issue)/page/year: 49,150,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 74 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   BNEOBV Biology of the Neonate.  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.15-    1970-  Volume(issue)/page/year: 49,150,1986

其他信息

  • 方法一:以水合肼及尿素为原料，经缩合而得氨基脲液，然后加入盐酸进行酸化络合，经水冷结晶即得成品。在反应过程中生成的氨、用废酸（盐酸、硫酸混合液）中和后可用作肥料。
  • 用途四:用作分析试剂和色层分析试剂
  • 溶于水，不溶于无水乙醇和乙醚。
  • Sigma Aldrich:563-41-7(sigmaaldrich)
  • 用途一:本品是医药工业原料，用以制取硝基呋喃类等药物，也用作测定酮、醛的试剂，色谱分析及分离激素的精油的溶剂，也是农药中间体
  • 用途五:本品是医药工业的原料，用以制取硝基呋喃类等药物。也用作测定酮、醛的试剂、色谱分析试剂及分离激素和精油的溶剂。
  • 盐酸氨基脲价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30164017 氨基脲盐酸盐;盐酸氨脲 250g 114元 2011/08/23 30164014 氨基脲盐酸盐;盐酸氨脲 25g 23元 2011/04/16 S0032 盐酸氨基脲 Semicarbazide Hydrochloride 500G 800元
  • TCI Shanghai:盐酸氨基脲 Semicarbazide Hydrochloride,>;98.5%(T)(563-41-7)
  • 用途二:是医药、农药的中间体，用于制呋喃西林、硝基呋喃妥因等药物
  • 用途三:用作医药原料，用以制取硝基呋喃类药物
  • 下游产品:氨基脲 --> 3-苯基-1H-吡唑-4-甲醛 --> 5-氯-4-氯甲基-1,2,3-噻二唑 --> 3-氨基-5-苯基吡唑 --> 3-(4-氟丙基)-1H-吡唑-4-甲醛 --> 4-苯基-1，2，3-噻重氮-5-羧酸乙酯 --> 4,5-二氯哒嗪-3(2H)-酮 --> 6-氮杂胸腺嘧啶
  • 图谱信息:盐酸氨基脲(563-41-7)红外图谱(IR2) 盐酸氨基脲(563-41-7)质谱(MS) 盐酸氨基脲(563-41-7)红外图谱(IR1) 盐酸氨基脲(563-41-7)核磁图( 13 CNMR) 盐酸氨基脲(563-41-7)Raman光谱
  • Acros Organics:硝基呋喃代谢产物-呋喃西林SEM(盐酸氨基脲) Semicarbazide hydrochloride, 98%(563-41-7)
  • Alfa Aesar:氨基脲盐酸盐,99% Semicarbazide hydrochloride, 99%(563-41-7)
  • MOL 文件:563-41-7.mol
  • 上游原料:水合肼 --> 水合肼 --> 氨基脲

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Applications
  3. Food & Beverage Analysis - Applications
  4. Processing/Packaging Contaminants - Food & Beverage Analysis
  5. Semicarbazide - Processing/Packaging Contaminants
  6. Analytical Standard - Semicarbazide
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Ureas - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Lactones
  1. Functional Group 官能团索引
  2. semicarbazide

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